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Nrxn1tm1Sud
Targeted Allele Detail
Summary
Symbol: Nrxn1tm1Sud
Name: neurexin I; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:3042794
Synonyms: Nrxn1alphaKO, SKO2
Gene: Nrxn1  Location: Chr17:90341059-91400499 bp, - strand  Genetic Position: Chr17, 59.73 cM
Alliance: Nrxn1tm1Sud page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45298
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced the first exon, which contains the complete 5' UTR, start codon, signal peptide and the first LNS domain. Protein was undetected by Western blot analysis of mutant mice. (J:45298)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrxn1 Mutation:  95 strains or lines available
References
Original:  J:45298 Geppert M, et al., Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action. J Biol Chem. 1998 Jan 16;273(3):1705-10
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory