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Barx2 Gene Detail
Summary
  • Symbol
    Barx2
  • Name
    BarH-like homeobox 2
  • Synonyms
    2310006E12Rik, Barx2b
  • Feature Type
    protein coding gene
  • IDs
    MGI:109617
    NCBI Gene: 12023
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:31846044-31913285 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 17.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    233 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109617
 protein coding gene Chr9:31846044-31913462 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034521
 protein coding gene Chr9:29548596-29624871 (-)
A/J MGP_AJ_G0034499
 protein coding gene Chr9:28810606-28879516 (-)
AKR/J MGP_AKRJ_G0034425
 protein coding gene Chr9:29416127-29486684 (-)
BALB/cJ MGP_BALBcJ_G0034490
 protein coding gene Chr9:28700818-28769760 (-)
C3H/HeJ MGP_C3HHeJ_G0034202
 protein coding gene Chr9:29769320-29841554 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035011
 protein coding gene Chr9:30563217-30635706 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031941
 protein coding gene Chr9:27627658-27694844 (-)
CAST/EiJ MGP_CASTEiJ_G0033525
 protein coding gene Chr9:29629563-29699867 (-)
CBA/J MGP_CBAJ_G0034176
 protein coding gene Chr9:31564768-31635708 (-)
DBA/2J MGP_DBA2J_G0034333
 protein coding gene Chr9:28826948-28895580 (-)
FVB/NJ MGP_FVBNJ_G0034276
 protein coding gene Chr9:28224563-28292878 (-)
LP/J MGP_LPJ_G0034419
 protein coding gene Chr9:29772119-29845666 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034320
 protein coding gene Chr9:33182501-33259666 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035031
 protein coding gene Chr9:29404731-29478434 (-)
PWK/PhJ MGP_PWKPhJ_G0033230
 protein coding gene Chr9:28774807-28843833 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033065
 protein coding gene Chr9:29527571-29595960 (-)
WSB/EiJ MGP_WSBEiJ_G0033640
 protein coding gene Chr9:29159163-29231350 (-)



Homology
more
  • Human Ortholog
    BARX2, BARX homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BARX2, BARX homeobox 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 8538
    neXtProt AC: NX_Q9UMQ3
    UniProt: Q9UMQ3

  • Chr Location
    11q24.3; chr11:129375237-129452279 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 2715
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BARX2
  • Gene Tree
    Barx2
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted gene deletion exhibit short whiskers at birth, defective juvenile hair follicle remodeling, and short adult hair. Fifty percent of homozygotes are born with open eyelids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    334
  • Tissues
    144
  • cDNA Data
    20
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12023 NCBI Gene Model | MGI Sequence Detail 67242 C57BL/6J ±  kb
    transcript NM_013800 RefSeq | MGI Sequence Detail 1791 Not Specified  
    polypeptide O08686 UniProt | EBI | MGI Sequence Detail 283 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 20
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39616, MGI:1916722
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 20
      Diseases 1
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:39325 Jones FS, et al., Barx2, a new homeobox gene of the Bar class, is expressed in neural and craniofacial structures during development. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2632-7
    • Latest
      J:278227 Li H, et al., The molecular anatomy of mammalian upper lip and primary palate fusion at single cell resolution. Development. 2019 Jun 17;146(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    02/11/2020
    MGI 6.14     		The Jackson Laboratory