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Barx2 Gene Detail
Summary
  • Symbol
    Barx2
  • Name
    BarH-like homeobox 2
  • Synonyms
    2310006E12Rik, Barx2b
  • Feature Type
    protein coding gene
  • IDs
    MGI:109617
    NCBI Gene: 12023
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr9:31846044-31913462 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      67419 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 17.25 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BARX2, BARX homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BARX2, BARX homeobox 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 8538
    neXtProt AC: NX_Q9UMQ3
    UniProt: Q9UMQ3

  • Chr Location
    11q24.3; chr11:129375237-129452279 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 2715
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BARX2
  • Gene Tree
    Barx2
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted gene deletion exhibit short whiskers at birth, defective juvenile hair follicle remodeling, and short adult hair. Fifty percent of homozygotes are born with open eyelids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    329
  • Tissues
    140
  • cDNA Data
    20
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037222 VEGA Gene Model | MGI Sequence Detail 67419 C57BL/6J ±  kb
    transcript OTTMUST00000095990 VEGA | MGI Sequence Detail 1968 Not Applicable  
    polypeptide OTTMUSP00000053585 VEGA | MGI Sequence Detail 283 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      233 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 20
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39616, MGI:1916722
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:39325 Jones FS, et al., Barx2, a new homeobox gene of the Bar class, is expressed in neural and craniofacial structures during development. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2632-7
    • Latest
      J:258771 Hulin JA, et al., Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with beta-Catenin and Chromatin Remodelling. Stem Cells. 2016 Aug;34(8):2169-82
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory