Barx2
Gene Detail

Symbol

Name
ID

Barx2
BarH-like homeobox 2
MGI:109617

Synonyms

2310006E12Rik, Barx2b

Feature Type

protein coding gene

Genetic Map

Chromosome 9
17.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:31846044-31913462 bp, - strand From VEGA annotation of GRCm38   67419 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2715  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Barx2

Human
homologs

Human Homolog		BARX2, BARX homeobox 2
NCBI Gene ID		8538
neXtProt AC		NX_Q9UMQ3
Human Chr (Location)		11q25; chr11:129375986-129452279 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 

Mice homozygous for a targeted gene deletion exhibit short whiskers at birth, defective juvenile hair follicle remodeling, and short adult hair. Fifty percent of homozygotes are born with open eyelids.

 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)

Interactions

Barx2 interacts with 73 markers (Mir30c-1, Mir30c-2, Mir124a-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (24 annotations)

Process	cartilage condensation, catagen, ...
Component	nucleolus, nucleus, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)

Data Summary: Results (312)    Tissues (132)    Images (57)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	5
RNA in situ	252
In situ reporter (knock in)	12
Northern blot	9
Western blot	3
RT-PCR	11
RNase protection	20

cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(20) cDNA(17) Primer pair(2) Other(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000037222 (Evidence)
Ensembl Gene Model	ENSMUSG00000032033 (Evidence)
Entrez Gene	12023 (Evidence)
UniGene	261044
DFCI	TC1590628, TC1698392, TC1712767
DoTS	DT.91342096, DT.91327424, DT.91321077
NIA Mouse Gene Index	U030650
Consensus CDS Project	CCDS52750.1
International Mouse Knockout Project Status	Barx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037222	VEGA Gene Model | MGI Sequence Detail	67419	C57BL/6J
transcript	OTTMUST00000095990	VEGA | MGI Sequence Detail	1968	Not Applicable
polypeptide	OTTMUSP00000053585	VEGA | MGI Sequence Detail	283	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(233 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000047	Helix-turn-helix motif
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000004646	homeobox protein BarH-like 2

References

(Earliest) J:39325 Jones FS, et al., Barx2, a new homeobox gene of the Bar class, is expressed in neural and craniofacial structures during development. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2632-7
(Latest) J:216784 Zhuang L, et al., Barx2 and Pax7 have antagonistic functions in regulation of wnt signaling and satellite cell differentiation. Stem Cells. 2014 Jun;32(6):1661-73
All references(51)

Other
accession IDs

MGD-MRK-39616, MGI:1916722