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Barx2 Gene Detail
Summary
  • Symbol
    Barx2
  • Name
    BarH-like homeobox 2
  • Synonyms
    2310006E12Rik, Barx2b
  • Feature Type
    protein coding gene
  • IDs
    MGI:109617
    NCBI Gene: 12023
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:31757340-31824581 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 17.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1698 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109617
 protein coding gene Chr9:31757340-31824758 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034521
 protein coding gene Chr9:29548596-29624871 (-)
A/J MGP_AJ_G0034499
 protein coding gene Chr9:28810606-28879516 (-)
AKR/J MGP_AKRJ_G0034425
 protein coding gene Chr9:29416127-29486684 (-)
BALB/cJ MGP_BALBcJ_G0034490
 protein coding gene Chr9:28700818-28769760 (-)
C3H/HeJ MGP_C3HHeJ_G0034202
 protein coding gene Chr9:29769320-29841554 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035011
 protein coding gene Chr9:30563217-30635706 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031941
 protein coding gene Chr9:27627658-27694844 (-)
CAST/EiJ MGP_CASTEiJ_G0033525
 protein coding gene Chr9:29629563-29699867 (-)
CBA/J MGP_CBAJ_G0034176
 protein coding gene Chr9:31564768-31635708 (-)
DBA/2J MGP_DBA2J_G0034333
 protein coding gene Chr9:28826948-28895580 (-)
FVB/NJ MGP_FVBNJ_G0034276
 protein coding gene Chr9:28224563-28292878 (-)
LP/J MGP_LPJ_G0034419
 protein coding gene Chr9:29772119-29845666 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034320
 protein coding gene Chr9:33182501-33259666 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035031
 protein coding gene Chr9:29404731-29478434 (-)
PWK/PhJ MGP_PWKPhJ_G0033230
 protein coding gene Chr9:28774807-28843833 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033065
 protein coding gene Chr9:29527571-29595960 (-)
WSB/EiJ MGP_WSBEiJ_G0033640
 protein coding gene Chr9:29159163-29231350 (-)



Homology
more
  • Human Ortholog
    BARX2, BARX homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BARX2, BARX homeobox 2
  • Links
    NCBI Gene ID: 8538
    UniProt: Q9UMQ3

  • Chr Location
    11q24.3; chr11:129375233-129452279 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted gene deletion exhibit short whiskers at birth, defective juvenile hair follicle remodeling, and short adult hair. Fifty percent of homozygotes are born with open eyelids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1124
  • Tissues
    210
  • cDNA Data
    21
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12023 NCBI Gene Model | MGI Sequence Detail 67242 C57BL/6J ±  kb
    transcript NM_013800 RefSeq | MGI Sequence Detail 1791 Not Specified  
    polypeptide O08686 UniProt | EBI | MGI Sequence Detail 283 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 21
      Primer pair 5
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39616, MGI:1916722
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 24
      Diseases 1
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:39325 Jones FS, et al., Barx2, a new homeobox gene of the Bar class, is expressed in neural and craniofacial structures during development. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2632-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory