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Dnm2
Gene Detail
Symbol

Name
ID
Dnm2
dynamin 2
MGI:109547
Synonyms
b2b2159Clo, Dyn2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
7.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:21424908-21507759 bp, + strand
From VEGA annotation of GRCm38

  82852 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:90883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DNM2
Protein SuperFamily: dynamin, metazoan type
Gene Tree: Dnm2

Human
homologs
DNM2, dynamin 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1785
neXtProt AC: NX_P50570

Human Synonyms: CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5

Human Chr (Location): 19p13.2; chr19:10718053-10831910 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human DNM2

Mutations,
alleles, and
phenotypes
All mutations/alleles(90) : Chemically induced (ENU)(1) Gene trapped(83) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted allele die prior to E8-E12. Mice heterozygous for a knock-out allele exhibit muscle atrophy and weakness, intermyofibrillar disorganization, and centrally localized mitochondria and sarcoplasmic reticulum.
 
Human Diseases Modeled in Mice Using Dnm2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(19)
Interactions
Dnm2 interacts with 155 markers (Mir17, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process cellular response to dopamine, cilium morphogenesis, ...
Component cell junction, centrosome, ...
Function D2 dopamine receptor binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (43)    Tissues (29)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 41
cDNA source data(125)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase dnm2 ; ZFIN dnm2a, dnm2b    NEW 
Molecular
reagents
All nucleic(126) cDNA(126)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000038087 (Evidence)
Ensembl Gene Model ENSMUSG00000033335 (Evidence)
Entrez Gene 13430 (Evidence)
UniGene 433257
DFCI TC1572875, TC1581958, TC1588945, TC1596951, TC1778459
NIA Mouse Gene Index U010144
EC 3.6.5.5
Consensus CDS Project CCDS57657.1, CCDS57658.1, CCDS57659.1, CCDS57660.1
International Mouse Phenotyping Consortium Status Dnm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038087 VEGA Gene Model | MGI Sequence Detail 82852 C57BL/6J ±  kb
transcript OTTMUST00000098111 VEGA | MGI Sequence Detail 3502 Not Applicable 
polypeptide OTTMUSP00000055075 VEGA | MGI Sequence Detail 870 Not Applicable 

For the selected sequences
All sequences(140) RefSeq(36) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(160 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027188 Dynamin-2
InterPro IPR000375 Dynamin central domain
InterPro IPR001401 Dynamin, GTPase domain
InterPro IPR003130 Dynamin GTPase effector
InterPro IPR019762 Dynamin, GTPase region, conserved site
InterPro IPR022812 Dynamin superfamily
InterPro IPR030381 Dynamin-type guanine nucleotide-binding (G) domain
InterPro IPR020850 GTPase effector domain, GED
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006603 dynamin-2
References
(Earliest) J:39830 Klocke R, et al., Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively. Genomics. 1997 Apr 15;41(2):290-2
(Latest) J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4
All references(73)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-39546, MGI:5491163

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory