Dnm2
Gene Detail

Symbol Name ID

Dnm2 dynamin 2 MGI:109547

Synonyms

Dyn2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

7.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:21424908-21507759 bp, + strand From VEGA annotation of GRCm38   82852 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:90883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: dynamin, metazoan type
Gene Tree: Dnm2

Human homologs

Human Homolog		DNM2, dynamin 2
NCBI Gene ID		1785
neXtProt AC		NX_P50570
Human Synonyms		CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII
Human Chr (Location)		19p13.2; chr19:10828729-10942586 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human DNM2

Alleles and phenotypes

All alleles(89) : Targeted(6) Gene trapped(83)
 

Mice homozygous for a targeted allele die prior to E8-E12. Mice heterozygous for a knock-out allele exhibit muscle atrophy and weakness, intermyofibrillar disorganization, and centrally localized mitochondria and sarcoplasmic reticulum.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	endocytosis, receptor internalization, ...
Component	cell junction, clathrin-coated endocytic vesicle, ...
Function	GTPase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (43)    Tissues (29)    Images (13)
Theiler Stages: 19, 23, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	41

cDNA source data(132)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(133) cDNA(133)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000038087 (Evidence)
Ensembl Gene Model	ENSMUSG00000033335 (Evidence)
Entrez Gene	13430 (Evidence)
UniGene	433257
DFCI	TC1572875, TC1581958, TC1588945, TC1596951, TC1778459
NIA Mouse Gene Index	U010144
EC	3.6.5.5
Consensus CDS Project	CCDS57657.1, CCDS57658.1, CCDS57659.1, CCDS57660.1
International Mouse Knockout Project Status	Dnm2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000038087	VEGA Gene Model | MGI Sequence Detail	82852	C57BL/6J
transcript	OTTMUST00000098111	VEGA | MGI Sequence Detail	3502	Not Applicable
polypeptide	OTTMUSP00000055075	VEGA | MGI Sequence Detail	870	Not Applicable

All sequences(109) RefSeq(8) UniProt(11)

Polymorphisms

RFLP(1) : SNPs(151 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022812	Dynamin
InterPro	IPR027188	Dynamin-2
InterPro	IPR000375	Dynamin central domain
InterPro	IPR001401	Dynamin, GTPase domain
InterPro	IPR003130	Dynamin GTPase effector
InterPro	IPR019762	Dynamin, GTPase region, conserved site
InterPro	IPR020850	GTPase effector domain, GED
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000006603	dynamin-2

References

(Earliest) J:39830 Klocke R, et al., Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively. Genomics. 1997 Apr 15;41(2):290-2
(Latest) J:194200 Soda K, et al., Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. J Clin Invest. 2012 Dec 3;122(12):4401-11
All references(57)

Other accession IDs

MGD-MRK-39546