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Dnm2 Gene Detail
Summary
  • Symbol
    Dnm2
  • Name
    dynamin 2
  • Synonyms
    b2b2159Clo, Dyn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109547
    NCBI Gene: 13430
  • Gene Overview
    MyGene.info: DNM2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:21424908-21507759 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      82852 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.79 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DNM2, dynamin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DNM2, dynamin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5
  • Links
    NCBI Gene ID: 1785
    neXtProt AC: NX_P50570
    UniProt: P50570

  • Chr Location
    19p13.2; chr19:10718053-10831910 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Dnm2 mouse models; 2 with human DNM2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 5 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    19 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele die prior to E8-E12. Mice heterozygous for a knock-out allele exhibit muscle atrophy and weakness, intermyofibrillar disorganization, and centrally localized mitochondria and sarcoplasmic reticulum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000038087 VEGA Gene Model | MGI Sequence Detail 82852 C57BL/6J ±  kb
    transcript OTTMUST00000098121 VEGA | MGI Sequence Detail 2613 Not Applicable  
    polypeptide OTTMUSP00000055080 VEGA | MGI Sequence Detail 870 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      160 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 127
      cDNA 127

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-39546, MGI:5491163
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 11
      Phenotypes 32
    • Earliest
      J:39830 Klocke R, et al., Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively. Genomics. 1997 Apr 15;41(2):290-2
    • Latest
      J:261350 Trochet D, et al., Allele-specific silencing therapy for Dynamin 2-related dominant centronuclear myopathy. EMBO Mol Med. 2018 Feb;10(2):239-253

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory