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Slc4a2
Gene Detail
Symbol

Name
ID
Slc4a2
solute carrier family 4 (anion exchanger), member 2
MGI:109351
Synonyms
Ae2, B3RP
Feature Type
protein coding gene
Genetic Map
Chromosome 5
11.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:24423837-24440950 bp, + strand
From VEGA annotation of GRCm38

  17114 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128699  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: band 3-like protein
Gene Tree: Slc4a2

Human
homologs
Human Homolog SLC4A2, solute carrier family 4 (anion exchanger), member 2
NCBI Gene ID 6522
neXtProt AC  NX_P04920
Human Synonyms  AE2, BND3L, EPB3L1, HKB3, NBND3
Human Chr (Location)  7q36.1; chr7:151058212-151076527 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a mutant allele display male infertility associated with disrupted spermiogenesis and germ cell apoptosis. However, mice homozygous for a null allele display perinatal and postnatal lethality, loss of gastric acid secretion, failure of tooth eruption, aphagia, and deafness.
 
Phenotype Images(9)
Interactions
Slc4a2 interacts with 52 markers (Mir17, Mir18b, Mir20a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (52)    Tissues (7)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 52
cDNA source data(115)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(116) cDNA(115) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024167 (Evidence)
Ensembl Gene ModelENSMUSG00000028962 (Evidence)
Entrez Gene20535 (Evidence)
UniGene4580
DFCITC1572857
DoTSDT.101704549, DT.87073656, DT.87068530
NIA Mouse Gene IndexU005362
Consensus CDS ProjectCCDS19119.1
International Mouse Knockout Project StatusSlc4a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024167 VEGA Gene Model | MGI Sequence Detail 17114 C57BL/6J ±  kb
transcript OTTMUST00000059116 VEGA | MGI Sequence Detail 4179 Not Applicable 
polypeptide OTTMUSP00000028731 VEGA | MGI Sequence Detail 1237 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(19) UniProt(13)
Polymorphisms
RFLP(2) : SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018241 Anion exchange, conserved site
InterPro IPR001717 Anion exchange protein
InterPro IPR002978 Anion exchange protein 2
InterPro IPR013769 Band 3 cytoplasmic domain
InterPro IPR011531 Bicarbonate transporter, C-terminal
InterPro IPR003020 Bicarbonate transporter, eukaryotic
InterPro IPR016152 Phosphotransferase/anion transporter
Protein Ontology PR:000015158 anion exchange protein 2
References
(Earliest) J:8444 Palumbo AP, et al., Chromosomal localization of a human band 3-like gene to region 7q35----7q36. Am J Hum Genet. 1986 Sep;39(3):307-16
(Latest) J:210863 Mardones P, et al., Cyclic AMP and alkaline pH downregulate carbonic anhydrase 2 in mouse fibroblasts. Biochim Biophys Acta. 2014 Jun;1840(6):1765-70
All references(62)
Other
accession IDs
MGD-MRK-1168, MGD-MRK-38396

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory