About   Help   FAQ
Slc4a2 Gene Detail
Summary
  • Symbol
    Slc4a2
  • Name
    solute carrier family 4 (anion exchanger), member 2
  • Synonyms
    Ae2, B3RP
  • Feature Type
    protein coding gene
  • IDs
    MGI:109351
    NCBI Gene: 20535
  • Gene Overview
    MyGene.info: SLC4A2
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:24423837-24440950 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 11.74 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109351
protein coding gene Chr5:24423761-24440950 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029343
protein coding gene Chr5:22149557-22168617 (+)
A/J MGP_AJ_G0029309
protein coding gene Chr5:21396589-21413762 (+)
AKR/J MGP_AKRJ_G0029260
protein coding gene Chr5:22256895-22275219 (+)
BALB/cJ MGP_BALBcJ_G0029320
protein coding gene Chr5:21909733-21926856 (+)
C3H/HeJ MGP_C3HHeJ_G0029040
protein coding gene Chr5:22370036-22389464 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029773
protein coding gene Chr5:23644847-23661958 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027011
protein coding gene Chr5:19339011-19356019 (+)
CAST/EiJ MGP_CASTEiJ_G0028452
protein coding gene Chr5:21543921-21562478 (+)
CBA/J MGP_CBAJ_G0029007
protein coding gene Chr5:24029822-24049861 (+)
DBA/2J MGP_DBA2J_G0029158
protein coding gene Chr5:21689787-21706829 (+)
FVB/NJ MGP_FVBNJ_G0029116
protein coding gene Chr5:21058284-21076084 (+)
LP/J MGP_LPJ_G0029242
protein coding gene Chr5:22549455-22573383 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029145
protein coding gene Chr5:25153994-25172491 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029807
protein coding gene Chr5:21899126-21917781 (+)
PWK/PhJ MGP_PWKPhJ_G0028176
protein coding gene Chr5:20767681-20785056 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028007
protein coding gene Chr5:21256021-21273031 (+)
WSB/EiJ MGP_WSBEiJ_G0028532
protein coding gene Chr5:21964615-21986049 (+)



Homology
more
  • Human Ortholog
    SLC4A2, solute carrier family 4 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC4A2, solute carrier family 4 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AE2, BND3L, EPB3L1, HKB3, NBND3
  • Links
    NCBI Gene ID: 6522
    neXtProt AC: NX_P04920
    UniProt: P04920

  • Chr Location
    7q36.1; chr7:151058212-151076527 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 3 alleles in 5 genetic backgrounds
    9 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice carrying an isoform-specific allele display male infertility associated with disrupted spermiogenesis and germ cell apoptosis. Mice homozygous for a null allele display perinatal and postnatal lethality, loss of gastric acid secretion, failure of tooth eruption, aphagia, and deafness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028962 Ensembl Gene Model | MGI Sequence Detail 17114 C57BL/6J ±  kb
    transcript ENSMUST00000080067 Ensembl | MGI Sequence Detail 4179 Not Applicable  
    polypeptide ENSMUSP00000078972 Ensembl | MGI Sequence Detail 1237 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 116
      cDNA 115
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1168, MGD-MRK-38396
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 8
      Phenotypes 32
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:255129 Bronckers AL, et al., Magnesium, pH regulation and modulation by mouse ameloblasts exposed to fluoride. Bone. 2017 Jan;94:56-64

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory