Sequence Detail

ID/Version

P13808 Q9ES13 Q9ES10 Q9ES12 Q9ES09 Q9ES11 (UniProt | EBI)

Last sequence update: 1990-01-01
Last annotation update: 2023-11-08

Sequence description from provider

RecName: Full=Anion exchange protein 2; Short=AE 2; Short=Anion exchanger 2;AltName: Full=Band 3-related protein; Short=B3RP;AltName: Full=Non-erythroid band 3-like protein;AltName: Full=Solute carrier family 4 member 2;

Provider

SWISS-PROT

Sequence

Polypeptide 1237 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc4a2	solute carrier family 4 (anion exchanger), member 2	32	101	4	17

Sequence references in MGI

J:9446 Alper SL, et al., Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line. J Biol Chem. 1988 Nov 15;263(32):17092-9
J:64830 Lecanda J, et al., Molecular cloning and genomic organization of the mouse AE2 anion exchanger gene. Biochem Biophys Res Commun. 2000 Sep 16;276(1):117-24
J:88196 Medina JF, et al., Anion exchanger 2 is essential for spermiogenesis in mice. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15847-52
J:143261 Wu J, et al., HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16934-9
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:193823 Coury F, et al., SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2163-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:331356 Nguyen HV, et al., Cl(-)/HCO(3)(-) exchange is acetazolamide sensitive and activated by a muscarinic receptor-induced [Ca(2+)](i) increase in salivary acinar cells. Am J Physiol Gastrointest Liver Physiol. 2004 Feb;286(2):G312-20
J:331357 Lindsey AE, et al., Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus. Proc Natl Acad Sci U S A. 1990 Jul;87(14):5278-82
J:331915 Concepcion AR, et al., Anion exchanger 2 is critical for CD8(+) T cells to maintain pHi homeostasis and modulate immune responses. Eur J Immunol. 2014 May;44(5):1341-51