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Irs2 Gene Detail
Summary
  • Symbol
    Irs2
  • Name
    insulin receptor substrate 2
  • Synonyms
    Irs-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109334
    NCBI Gene: 384783
  • Gene Overview
    MyGene.info: IRS2
Location & Maps
more
  • Sequence Map
    Chr8:10984681-11008458 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      23778 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.35 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IRS2, insulin receptor substrate 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IRS2, insulin receptor substrate 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IRS-2
  • Links
    NCBI Gene ID: 8660
    neXtProt AC: NX_Q9Y4H2
    UniProt: Q9Y4H2

  • Chr Location
    13q34; chr13:109753837-109786567 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Irs2 mouse models; 1 with human IRS2 associations

Human Disease Mouse Models
      
IDs
 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    76 phenotypes from 7 alleles in 11 genetic backgrounds
    38 phenotypes from multigenic genotypes
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene results in type 2 diabetes due to insulin resistance and pancreatic beta cell dysfunction, causes defects in leptin action, energy balance, lipid homeostasis and vascular wound healing, and leads to female infertility due to hypothalamic and ovarian dysfunction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    38
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    86
  • Tissues
    20
  • cDNA Data
    18
  • Literature Summary
    11
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059106 VEGA Gene Model | MGI Sequence Detail 23778 C57BL/6J ±  kb
transcript OTTMUST00000144972 VEGA | MGI Sequence Detail 6323 Not Applicable  
polypeptide OTTMUSP00000075523 VEGA | MGI Sequence Detail 1321 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    62 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    Genomic 20
    cDNA 18
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38379
References
more
  • Summaries
    All 156
    Developmental Gene Expression 11
    Diseases 3
    Gene Ontology 14
    Phenotypes 97
  • Earliest
    J:38317 Sun XJ, et al., Role of IRS-2 in insulin and cytokine signalling. Nature. 1995 Sep 14;377(6545):173-7
  • Latest
    J:240715 Xi G, et al., Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation. J Biol Chem. 2017 Feb 03;292(5):2009-2020
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/11/2017
MGI 6.10 		The Jackson Laboratory