Irs2
Gene Detail

Symbol

Name
ID

Irs2
insulin receptor substrate 2
MGI:109334

Synonyms

Irs-2

Feature Type

protein coding gene

Genetic Map

Chromosome 8
5.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:10986961-11008430 bp, - strand From NCBI annotation of GRCm38   21470 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2778  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: insulin receptor substrate
Gene Tree: Irs2

Human
homologs

Human Homolog		IRS2, insulin receptor substrate 2
NCBI Gene ID		8660
neXtProt AC		NX_Q9Y4H2
Human Synonyms		IRS-2
Human Chr (Location)		13q34; chr13:109753837-109786567 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human IRS2

Mutations,
alleles, and
phenotypes

All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous disruption of this gene results in type 2 diabetes due to insulin resistance and pancreatic beta cell dysfunction, causes defects in leptin action, energy balance, lipid homeostasis and vascular wound healing, and leads to female infertility due to hypothalamic and ovarian dysfunction.

 
Human Diseases Modeled in Mice Using Irs2 (1)    Mutations Annotated to Human Diseases (3)   

Interactions

Irs2 interacts with 5 markers (Mir298, Mir666, Mir701, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (36 annotations)

Process	brain development, cell proliferation, ...
Component	cytoplasm, cytosol, ...
Function	14-3-3 protein binding, insulin receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)

Data Summary: Results (86)    Tissues (20)    Images (19)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	83
RT-PCR	3

cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(39) Genomic(20) cDNA(18) Primer pair(1)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000038894 (Evidence)
Entrez Gene	384783 (Evidence)
UniGene	407207
DFCI	TC1668845
DoTS	DT.486942
NIA Mouse Gene Index	U029580
PDB	3BU6, 3BU5, 3BU3
Consensus CDS Project	CCDS52477.1
International Mouse Knockout Project Status	Irs2

Sequences

Length	Strain/Species
genomic	384783	NCBI Gene Model | MGI Sequence Detail	21470	C57BL/6J
transcript	NM_001081212	RefSeq | MGI Sequence Detail	4015	Not Specified
polypeptide	P81122	UniProt | EBI | MGI Sequence Detail	1321	Not Applicable

All sequences(15) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs within 2kb(47 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR002404	Insulin receptor substrate-1, PTB
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000009108	insulin receptor substrate 2

Graphical View of Protein Domain Structure

References

(Earliest) J:38317 Sun XJ, et al., Role of IRS-2 in insulin and cytokine signalling. Nature. 1995 Sep 14;377(6545):173-7
(Latest) J:213137 Shirakawa J, et al., Effects of the antitumor drug OSI-906, a dual inhibitor of IGF-1 receptor and insulin receptor, on the glycemic control, beta-cell functions, and beta-cell proliferation in male mice. Endocrinology. 2014 Jun;155(6):2102-11
All references(143)
Disease annotation references (4)

Other
accession IDs

MGD-MRK-38379