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Irs2 Gene Detail
Summary
  • Symbol
    Irs2
  • Name
    insulin receptor substrate 2
  • Synonyms
    Irs-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109334
    NCBI Gene: 384783
  • Gene Overview
    MyGene.info: IRS2
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:10986961-11008430 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109334
 protein coding gene Chr8:10984681-11008458 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033350
 protein coding gene Chr8:8178621-8200096 (-)
A/J MGP_AJ_G0033330
 protein coding gene Chr8:7895992-7917486 (-)
AKR/J MGP_AKRJ_G0033261
 protein coding gene Chr8:8134265-8157310 (-)
BALB/cJ MGP_BALBcJ_G0033331
 protein coding gene Chr8:8046739-8068216 (-)
C3H/HeJ MGP_C3HHeJ_G0033044
 protein coding gene Chr8:8304820-8326294 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033843
 protein coding gene Chr8:8523792-8545229 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030813
 protein coding gene Chr8:7419289-7440702 (-)
CAST/EiJ MGP_CASTEiJ_G0032366
 protein coding gene Chr8:8020334-8042877 (-)
CBA/J MGP_CBAJ_G0033017
 protein coding gene Chr8:8872939-8894476 (-)
DBA/2J MGP_DBA2J_G0033170
 protein coding gene Chr8:7885892-7907365 (-)
FVB/NJ MGP_FVBNJ_G0033119
 protein coding gene Chr8:7846047-7867519 (-)
LP/J MGP_LPJ_G0033264
 protein coding gene Chr8:8096293-8117772 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033153
 protein coding gene Chr8:9195951-9217505 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033860
 protein coding gene Chr8:8153265-8175910 (-)
PWK/PhJ MGP_PWKPhJ_G0032079
 protein coding gene Chr8:7863280-7886285 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031921
 protein coding gene Chr8:8076095-8100125 (-)
WSB/EiJ MGP_WSBEiJ_G0032482
 protein coding gene Chr8:8178350-8199806 (-)



Homology
more
  • Human Ortholog
    IRS2, insulin receptor substrate 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IRS2, insulin receptor substrate 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IRS-2
  • Links
    NCBI Gene ID: 8660
    neXtProt AC: NX_Q9Y4H2
    UniProt: Q9Y4H2

  • Chr Location
    13q34; chr13:109753837-109786567 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Irs2 mouse models; 1 with human IRS2 associations

Human Disease Mouse Models
      
IDs
 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    76 phenotypes from 8 alleles in 12 genetic backgrounds
    41 phenotypes from multigenic genotypes
    106 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene results in type 2 diabetes due to insulin resistance and pancreatic beta cell dysfunction, causes defects in leptin action, energy balance, lipid homeostasis and vascular wound healing, and leads to female infertility due to hypothalamic and ovarian dysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    86
  • Tissues
    20
  • cDNA Data
    20
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 384783 NCBI Gene Model | MGI Sequence Detail 21470 C57BL/6J ±  kb
    transcript NM_001081212 RefSeq | MGI Sequence Detail 6794 C57BL/6  
    polypeptide P81122 UniProt | EBI | MGI Sequence Detail 1321 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 20
      cDNA 20
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38379
    References
    more
    • Summaries
      All 191
      Developmental Gene Expression 13
      Diseases 3
      Gene Ontology 16
      Phenotypes 106
    • Earliest
      J:38317 Sun XJ, et al., Role of IRS-2 in insulin and cytokine signalling. Nature. 1995 Sep 14;377(6545):173-7
    • Latest
      J:267724 Kubota T, et al., Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity. Nat Commun. 2018 Nov 19;9(1):4863
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    01/15/2019
    MGI 6.13     		The Jackson Laboratory