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Irs2
Gene Detail
Symbol

Name
ID
Irs2
insulin receptor substrate 2
MGI:109334
Synonyms
Irs-2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
5.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:10986961-11008430 bp, - strand
From NCBI annotation of GRCm38

  21470 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2778  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: IRS2
Protein SuperFamily: insulin receptor substrate
Gene Tree: Irs2

Human
homologs
IRS2, insulin receptor substrate 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8660
neXtProt AC: NX_Q9Y4H2

Human Synonyms: IRS-2

Human Chr (Location): 13q34; chr13:109753837-109786567 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IRS2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous disruption of this gene results in type 2 diabetes due to insulin resistance and pancreatic beta cell dysfunction, causes defects in leptin action, energy balance, lipid homeostasis and vascular wound healing, and leads to female infertility due to hypothalamic and ovarian dysfunction.
 
Human Diseases Modeled in Mice Using Irs2 (1)    Mutations Annotated to Human Diseases (3)   
Interactions
Irs2 interacts with 5 markers (Mir298, Mir666, Mir701, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process brain development, cell proliferation, ...
Component cytoplasm, cytosol, ...
Function 14-3-3 protein binding, insulin receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (86)    Tissues (20)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 83
RT-PCR 3
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase irs2    NEW 
Molecular
reagents
All nucleic(39) Genomic(20) cDNA(18) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000038894 (Evidence)
Entrez Gene 384783 (Evidence)
UniGene 407207
DFCI TC1668845
DoTS DT.486942
NIA Mouse Gene Index U029580
PDB 3BU3, 3BU5, 3BU6
Consensus CDS Project CCDS52477.1
International Mouse Phenotyping Consortium Status Irs2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 384783 NCBI Gene Model | MGI Sequence Detail 21470 C57BL/6J ±  kb
transcript NM_001081212 RefSeq | MGI Sequence Detail 4015 Not Specified 
polypeptide P81122 UniProt | EBI | MGI Sequence Detail 1321 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002404 IRS-type PTB domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Protein Ontology PR:000009108 insulin receptor substrate 2
Graphical View of Protein Domain Structure
References
(Earliest) J:38317 Sun XJ, et al., Role of IRS-2 in insulin and cytokine signalling. Nature. 1995 Sep 14;377(6545):173-7
(Latest) J:218271 Alvarez-Perez JC, et al., Hepatocyte growth factor ameliorates hyperglycemia and corrects beta-cell mass in IRS2-deficient mice. Mol Endocrinol. 2014 Dec;28(12):2038-48
All references(142)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-38379

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory