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Nat2
Gene Detail
Symbol

Name
ID
Nat2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
MGI:109201
Feature Type
protein coding gene
Genetic Map
Chromosome 8
33.38 cM, cytoband B3.1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:67494875-67502580 bp, + strand
From NCBI annotation of GRCm38

  7706 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37329  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 3 chicken; 4 zebrafish

Protein SuperFamily: N-hydroxyarylamine O-acetyltransferase/arylamine N-acetyltransferase/3-amino-5-hydroxybenzoic acid synthase
Gene Tree: Nat2

Human
homologs
Human Homolog NAT1, N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCBI Gene ID 9
neXtProt AC  NX_P18440
Human Synonyms  AAC1, MNAT, NAT-1, NATI
Human Chr (Location)  8p22; chr8:18170462-18223689 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this gene does not result in an overt phenotype.
 
Phenotype Images(2)
Interactions
Nat2 interacts with 85 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process metabolic process
Component cytoplasm, cytosol
Function acetyltransferase activity, arylamine N-acetyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (140)    Tissues (121)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
In situ reporter (knock in) 27
Western blot 9
RT-PCR 10
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(7) cDNA(12) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000051147 (Evidence)
Entrez Gene17961 (Evidence)
UniGene4695
DFCITC1586888
DoTSDT.40145596, DT.40154366, DT.91336569
EC2.3.1.5
Consensus CDS ProjectCCDS22338.1
International Mouse Knockout Project StatusNat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17961 NCBI Gene Model | MGI Sequence Detail 7706 C57BL/6J ±  kb
transcript NM_010874 RefSeq | MGI Sequence Detail 1473 C57BL/6 
polypeptide P50295 UniProt | EBI | MGI Sequence Detail 290 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(162 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001447 Arylamine N-acetyltransferase
Protein Ontology PR:000011001 arylamine N-acetyltransferase 2
Graphical View of Protein Domain Structure
References
(Earliest) J:8150 Ebihara S, et al., Genetic control of melatonin synthesis in the pineal gland of the mouse. Science. 1986 Jan 31;231(4737):491-3
(Latest) J:209242 Witham KL, et al., 5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. PLoS One. 2013;8(10):e77923
All references(48)
Other
accession IDs
MGD-MRK-38245, MGI:2142742

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory