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Nat2 Gene Detail
Summary
  • Symbol
    Nat2
  • Name
    N-acetyltransferase 2 (arylamine N-acetyltransferase)
  • Feature Type
    protein coding gene
  • IDs
    MGI:109201
    NCBI Gene: 17961
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:67494858-67502584 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7727 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 33.38 cM, cytoband B3.1
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    NAT1, N-acetyltransferase 1
  • Vertebrate Orthologs
    13
  • Human Ortholog
    NAT1, N-acetyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAC1, MNAT, NAT-1, NATI
  • Links
    NCBI Gene ID: 9
    neXtProt AC: NX_P18440
    UniProt: P18440

  • Chr Location
    8p22; chr8:18170419-18223689 (+)  GRCh38.p7

  • Human Ortholog
    NAT2, N-acetyltransferase 2
    Orthology source: HGNC
  • Synonyms
    AAC2, NAT-2, PNAT
  • Links
    NCBI Gene ID: 10
    neXtProt AC: NX_P11245
    UniProt: P11245

  • Chr Location
    8p22; chr8:18386585-18401219 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 6 genetic backgrounds
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene does not result in an overt phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061938 VEGA Gene Model | MGI Sequence Detail 7727 C57BL/6J ±  kb
    transcript OTTMUST00000151229 VEGA | MGI Sequence Detail 1396 Not Applicable  
    polypeptide OTTMUSP00000078428 VEGA | MGI Sequence Detail 290 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      151 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 7
      cDNA 12
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-38245, MGI:2142742
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:8150 Ebihara S, et al., Genetic control of melatonin synthesis in the pineal gland of the mouse. Science. 1986 Jan 31;231(4737):491-3
    • Latest
      J:252637 Wang P, et al., Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver. Biochem Pharmacol. 2017 Dec 1;145:218-225

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory