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Nat2 Gene Detail
Summary
  • Symbol
    Nat2
  • Name
    N-acetyltransferase 2 (arylamine N-acetyltransferase)
  • Feature Type
    protein coding gene
  • IDs
    MGI:109201
    NCBI Gene: 17961
  • Gene Overview
    MyGene.info: NAT1
Location & Maps
more
  • Sequence Map
    Chr8:67494867-67502580 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7714 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NAT1, N-acetyltransferase 1 (arylamine N-acetyltransferase)
  • Vertebrate Orthologs
    13
  • Human Ortholog
    NAT1, N-acetyltransferase 1 (arylamine N-acetyltransferase)
    Orthology source: HomoloGene
  • Synonyms
    AAC1, MNAT, NAT-1, NATI
  • Links
    NCBI Gene ID: 9
    neXtProt AC: NX_P18440

  • Chr Location
    8p22; chr8:18170462-18223689 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 6 genetic backgrounds
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Nat2
  • Incidental Mutations
Inactivation of this gene does not result in an overt phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051147 Ensembl Gene Model | MGI Sequence Detail 7714 C57BL/6J ±  kb
transcript ENSMUST00000093470 Ensembl | MGI Sequence Detail 1379 Not Applicable  
polypeptide ENSMUSP00000091181 Ensembl | MGI Sequence Detail 290 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    151 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000044707 rodent arylamine N-acetyltransferase 2
  • EC
  • InterPro Domains
    IPR001447 Arylamine N-acetyltransferase
Molecular
Reagents
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  • All nucleic 20
    Genomic 7
    cDNA 12
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-38245, MGI:2142742
References
more
  • Summaries
    All 45
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:8150 Ebihara S, et al., Genetic control of melatonin synthesis in the pineal gland of the mouse. Science. 1986 Jan 31;231(4737):491-3
  • Latest
    J:217359 Laurieri N, et al., From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2. PLoS One. 2014;9(5):e96370

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory