Meis2 MGI Mouse Gene Detail - MGI:108564

Symbol

Meis2
Name

Meis homeobox 2
Synonyms

A430109D20Rik, Meis2, Mrg1, Stra10

Feature Type

protein coding gene
IDs

MGI:108564
NCBI Gene: 17536
Gene Overview

MyGene.info: MEIS2
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr2:115863064-116065839 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 58.28 cM
Mapping Data

4 experiments

SNPs within 2kb

1258 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108564	protein coding gene	Chr2:115861264-116067537 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026306	protein coding gene	Chr2:118427438-118633533 (-)
A/J	MGP_AJ_G0026267	protein coding gene	Chr2:113633370-113837164 (-)
AKR/J	MGP_AKRJ_G0026246	protein coding gene	Chr2:116791138-116998872 (-)
BALB/cJ	MGP_BALBcJ_G0026280	protein coding gene	Chr2:113869960-114073582 (-)
C3H/HeJ	MGP_C3HHeJ_G0026025	protein coding gene	Chr2:117217364-117425259 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026727	protein coding gene	Chr2:122334228-122542284 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024107	protein coding gene	Chr2:108748644-108956333 (-)
CAST/EiJ	MGP_CASTEiJ_G0025488	protein coding gene	Chr2:117525562-117744152 (-)
CBA/J	MGP_CBAJ_G0026002	protein coding gene	Chr2:126639073-126856335 (-)
DBA/2J	MGP_DBA2J_G0026141	protein coding gene	Chr2:113062201-113265662 (-)
FVB/NJ	MGP_FVBNJ_G0026103	protein coding gene	Chr2:111903263-112105847 (-)
LP/J	MGP_LPJ_G0026242	protein coding gene	Chr2:118732425-118937563 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026122	protein coding gene	Chr2:131080147-131291443 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026782	protein coding gene	Chr2:116893671-117102998 (-)
PWK/PhJ	MGP_PWKPhJ_G0025224	protein coding gene	Chr2:112617463-112823799 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025023	protein coding gene	Chr2:116030471-116239764 (-)
WSB/EiJ	MGP_WSBEiJ_G0025557	protein coding gene	Chr2:117707668-117913496 (-)

Human Ortholog

MEIS2, Meis homeobox 2

Vertebrate Orthologs

10

Human Ortholog

MEIS2, Meis homeobox 2
Orthology source: HomoloGene, HGNC
Synonyms

CPCMR, HsT18361, MRG1
Links

HGNC:7001

NCBI Gene ID: 4212

neXtProt AC: NX_O14770

UniProt: O14770
Chr Location

15q14; chr15:36891021-37101299 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7846
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: MEIS2
Gene Tree

Meis2

Diseases

1 with human MEIS2 associations

				Human Disease	Mouse Models
				cleft palate, cardiac defects, and intellectual disabillity IDs cleft palate, cardiac defects, and intellectual disabillity DOID:0111697 MESH:C563414 OMIM:600987 UMLS_CUI:C1832950

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

18 phenotypes from 1 allele in 1 genetic background
21 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Gene trapped

13
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Meis2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display early fetal lethality with hemorrhaging, persistent truncus arteriosis, absence of cardic valves and defects in other neural crest cell derived tissues.

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All GO Annotations

31
GO References

16

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1138
Tissues

366
cDNA Data

40
Literature Summary

124

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MEIS2

Xenbase meis2

ZFIN meis2a, meis2b

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Meis2 interacts with 453 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

176
RefSeq

62
UniProt

7
CCDS

CCDS16568.1, CCDS50664.1, CCDS50665.1, CCDS50666.1, CCDS50667.1, CCDS50668.1

Ensembl

ENSMUSG00000027210 (Evidence)
NCBI Gene

17536

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027210	Ensembl Gene Model \| MGI Sequence Detail	202776	C57BL/6J	± kb
transcript	ENSMUST00000028639	Ensembl \| MGI Sequence Detail	2831	Not Applicable
polypeptide	ENSMUSP00000028639	Ensembl \| MGI Sequence Detail	477	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010317 homeobox protein Meis2

(term hierarchy)
InterPro Domains

IPR001356 Homeobox domain

IPR008422 Homeobox KN domain

IPR009057 Homeobox-like domain superfamily

IPR032453 Homeobox protein PKNOX/Meis, N-terminal

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All nucleic 57

Genomic 1

cDNA 40

Primer pair 5

Other 11

Microarray probesets 4

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MGD-MRK-36505, MGD-MRK-37608, MGI:107925, MGI:2442113

Summaries

All 169

Developmental Gene Expression 124

Gene Ontology 16

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:294823 Fabik J, et al., Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway. Biol Open. 2020 Jul 2;9(6)

TSS for Meis2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25733	Chr2:116066034-116066063 (-)	-210 bp
Tssr25732	Chr2:116065944-116065965 (-)	-116 bp
Tssr25731	Chr2:116065798-116065853 (-)	13 bp
Tssr25730	Chr2:116065785-116065796 (-)	48 bp
Tssr25729	Chr2:116065718-116065735 (-)	112 bp
Tssr25728	Chr2:116065691-116065705 (-)	141 bp
Tssr25727	Chr2:116065673-116065689 (-)	158 bp
Tssr25726	Chr2:116065645-116065656 (-)	188 bp
Tssr25725	Chr2:116065217-116065238 (-)	611 bp
Tssr25724	Chr2:116065128-116065133 (-)	708 bp
Tssr25723	Chr2:116064759-116064771 (-)	1,074 bp
Tssr25722	Chr2:116064733-116064749 (-)	1,098 bp
Tssr25721	Chr2:116064558-116064598 (-)	1,261 bp
Tssr25719	Chr2:116062514-116062562 (-)	3,301 bp
Tssr25718	Chr2:116058788-116058799 (-)	7,045 bp
Tssr25712	Chr2:115864324-115864338 (-)	201,508 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/13/2020 MGI 6.16