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Meis2
Gene Detail
Symbol

Name
ID
Meis2
Meis homeobox 2
MGI:108564
Synonyms
A430109D20Rik, Meis2, Mrg1, Stra10
Feature Type
protein coding gene
Genetic Map
Chromosome 2
58.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:115863064-116065839 bp, - strand
From VEGA annotation of GRCm38

  202776 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7846  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Meis2

Human
homologs
Human Homolog MEIS2, Meis homeobox 2
NCBI Gene ID 4212
neXtProt AC  NX_O14770
Human Synonyms  HsT18361, MRG1
Human Chr (Location)  15q14; chr15:36891021-37101299 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(13) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Meis2 interacts with 454 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process eye development, multicellular organismal development, ...
Component nucleus
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (86 records)
Data Summary: Results (247)    Tissues (227)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 226
Northern blot 11
RT-PCR 10
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(1) cDNA(34) Primer pair(3) Other(5)
Microarray probesets(4)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015219 VEGA Gene Model | MGI Sequence Detail 202776 C57BL/6J ±  kb
transcript OTTMUST00000036124 VEGA | MGI Sequence Detail 2831 Not Applicable 
polypeptide OTTMUSP00000016227 VEGA | MGI Sequence Detail 477 Not Applicable 

For the selected sequences
All sequences(142) RefSeq(32) UniProt(11)
Polymorphisms
RFLP(2) : SNPs within 2kb(1261 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000010317 homeobox protein Meis2
References
(Earliest) J:28316 Bouillet P, et al., Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
(Latest) J:208353 Kondo T, et al., Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer. Dev Cell. 2014 Jan 13;28(1):94-101
All references(123)
Other
accession IDs
MGD-MRK-36505, MGD-MRK-37608, MGI:107925, MGI:2442113

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory