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Meis2
Gene Detail
 Symbol
Name
ID
Meis2
Meis homeobox 2
MGI:108564
Synonyms A430109D20Rik, Meis2, Mrg1, Stra10
Feature Type protein coding gene
Genetic Map
Chromosome 2
58.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:115863064-116065839 bp, - strand
From VEGA annotation of GRCm38

  202776 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7846  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Meis2

Human
homologs
Human Homolog MEIS2, Meis homeobox 2
NCBI Gene ID 4212
neXtProt AC  NX_O14770
Human Synonyms  HsT18361, MRG1
Human Chr (Location)  15q14; chr15:36891021-37101299 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(13) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Meis2 interacts with 454 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process eye development, multicellular organismal development, ...
Component nucleus
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (86 records)
Data Summary: Results (247)    Tissues (227)    Images (40)
Theiler Stages: 2, 3, 4, 5, 10, 11, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 27, 28
Assay TypeResults
RNA in situ 226
Northern blot 11
RT-PCR 10
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(1) cDNA(34) Primer pair(3) Other(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015219 (Evidence)
Ensembl Gene ModelENSMUSG00000027210 (Evidence)
Entrez Gene17536 (Evidence)
DFCITC1575848, TC1589889, TC1590536, TC1594077, TC1597283, TC1617509, TC1653265, TC1705791
DoTSDT.101367941, DT.101385872, DT.110660615, DT.110660634, DT.91334926, DT.91582994, DT.91596612, DT.94167178, DT.97333354, DT.97336010, DT.97336017
NIA Mouse Gene IndexU023195, U250375
Consensus CDS ProjectCCDS16568.1, CCDS50664.1, CCDS50665.1, CCDS50666.1, CCDS50667.1, CCDS50668.1
International Mouse Knockout Project StatusMeis2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015219 VEGA Gene Model | MGI Sequence Detail 202776 C57BL/6J ±  kb
transcript OTTMUST00000036124 VEGA | MGI Sequence Detail 2831 Not Applicable 
polypeptide OTTMUSP00000016227 VEGA | MGI Sequence Detail 477 Not Applicable 

For the selected sequences
All sequences(139) RefSeq(32) UniProt(8)
Polymorphisms RFLP(2) : SNPs within 2kb(1261 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000010317 homeobox protein Meis2
References (Earliest) J:28316 Bouillet P, et al., Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
(Latest) J:208353 Kondo T, et al., Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer. Dev Cell. 2014 Jan 13;28(1):94-101
All references(122)
Other
accession IDs
MGD-MRK-36505, MGD-MRK-37608, MGI:107925, MGI:2442113

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory