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Meis2 Gene Detail
Summary
  • Symbol
    Meis2
  • Name
    Meis homeobox 2
  • Synonyms
    A430109D20Rik, Meis2, Mrg1, Stra10
  • Feature Type
    protein coding gene
  • IDs
    MGI:108564
    NCBI Gene: 17536
  • Gene Overview
    MyGene.info: MEIS2
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:115863064-116065839 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 58.28 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1258 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108564
protein coding gene Chr2:115861264-116067553 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026306
protein coding gene Chr2:118427438-118633533 (-)
A/J MGP_AJ_G0026267
protein coding gene Chr2:113633370-113837164 (-)
AKR/J MGP_AKRJ_G0026246
protein coding gene Chr2:116791138-116998872 (-)
BALB/cJ MGP_BALBcJ_G0026280
protein coding gene Chr2:113869960-114073582 (-)
C3H/HeJ MGP_C3HHeJ_G0026025
protein coding gene Chr2:117217364-117425259 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026727
protein coding gene Chr2:122334228-122542284 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024107
protein coding gene Chr2:108748644-108956333 (-)
CAST/EiJ MGP_CASTEiJ_G0025488
protein coding gene Chr2:117525562-117744152 (-)
CBA/J MGP_CBAJ_G0026002
protein coding gene Chr2:126639073-126856335 (-)
DBA/2J MGP_DBA2J_G0026141
protein coding gene Chr2:113062201-113265662 (-)
FVB/NJ MGP_FVBNJ_G0026103
protein coding gene Chr2:111903263-112105847 (-)
LP/J MGP_LPJ_G0026242
protein coding gene Chr2:118732425-118937563 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026122
protein coding gene Chr2:131080147-131291443 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026782
protein coding gene Chr2:116893671-117102998 (-)
PWK/PhJ MGP_PWKPhJ_G0025224
protein coding gene Chr2:112617463-112823799 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025023
protein coding gene Chr2:116030471-116239764 (-)
WSB/EiJ MGP_WSBEiJ_G0025557
protein coding gene Chr2:117707668-117913496 (-)



Homology
more
  • Human Ortholog
    MEIS2, Meis homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MEIS2, Meis homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPCMR, HsT18361, MRG1
  • Links
    NCBI Gene ID: 4212
    neXtProt AC: NX_O14770
    UniProt: O14770

  • Chr Location
    15q14; chr15:36891021-37101299 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7846
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MEIS2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    21 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display early fetal lethality with hemorrhaging, persistent truncus arteriosis, absence of cardic valves and defects in other neural crest cell derived tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027210 Ensembl Gene Model | MGI Sequence Detail 202776 C57BL/6J ±  kb
    transcript ENSMUST00000028639 Ensembl | MGI Sequence Detail 2831 Not Applicable  
    polypeptide ENSMUSP00000028639 Ensembl | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 1
      cDNA 39
      Primer pair 5
      Other 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36505, MGD-MRK-37608, MGI:107925, MGI:2442113
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 107
      Gene Ontology 15
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory