Meis2
Gene Detail

Symbol

Name
ID

Meis2
Meis homeobox 2
MGI:108564

Synonyms

A430109D20Rik, Meis2, Mrg1, Stra10

Feature Type

protein coding gene

Genetic Map

Chromosome 2
58.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:115862613-116200104 bp, - strand From VEGA annotation of GRCm38   337492 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7846  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Meis2

Human
homologs

Human Homolog		MEIS2, Meis homeobox 2
NCBI Gene ID		4212
neXtProt AC		NX_O14770
Human Synonyms		HsT18361, MRG1
Human Chr (Location)		15q14; chr15:36891021-37101299 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(14) : Gene trapped(13) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Meis2 interacts with 454 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (18 annotations)

Process	eye development, multicellular organismal development, ...
Component	nucleus
Function	DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (86 records)

Data Summary: Results (247)    Tissues (227)    Images (44)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	226
Northern blot	11
RT-PCR	10

cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(43) Genomic(1) cDNA(34) Primer pair(3) Other(5)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000015219 (Evidence)
Ensembl Gene Model	ENSMUSG00000027210 (Evidence)
Entrez Gene	17536 (Evidence)
DFCI	TC1597283, TC1617509, TC1594077, TC1590536, TC1575848, TC1589889, TC1653265, TC1705791
DoTS	DT.91596612, DT.91334926, DT.110660634, DT.91582994, DT.101385872, DT.110660615, DT.101367941, DT.97333354, DT.94167178, DT.97336010, DT.97336017
NIA Mouse Gene Index	U250375, U023195
Consensus CDS Project	CCDS16568.1, CCDS50664.1, CCDS50665.1, CCDS50666.1, CCDS50667.1, CCDS50668.1
International Mouse Knockout Project Status	Meis2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015219	VEGA Gene Model | MGI Sequence Detail	337492	C57BL/6J
transcript	OTTMUST00000036124	VEGA | MGI Sequence Detail	2831	Not Applicable
polypeptide	OTTMUSP00000016227	VEGA | MGI Sequence Detail	477	Not Applicable

All sequences(145) RefSeq(40) UniProt(6)

Polymorphisms

RFLP(2) : SNPs within 2kb(1886 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1892)

Protein-related
information

Resource	ID	Description
InterPro	IPR008422	Homeobox KN domain
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000010317	homeobox protein Meis2

References

(Earliest) J:28316 Bouillet P, et al., Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
(Latest) J:208353 Kondo T, et al., Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer. Dev Cell. 2014 Jan 13;28(1):94-101
All references(123)

Other
accession IDs

MGD-MRK-36505, MGD-MRK-37608, MGI:107925, MGI:2442113