Meis2
Gene Detail

Symbol Name ID

Meis2 Meis homeobox 2 MGI:108564

Synonyms

A430109D20Rik, Meis2, Mrg1, Stra10

Feature Type

protein coding gene

Genetic Map

Chromosome 2

58.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:115863064-116065839 bp, - strand From VEGA annotation of GRCm38   202776 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7846  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Meis2

Human homologs

Human Homolog		MEIS2, Meis homeobox 2
NCBI Gene ID		4212
neXtProt AC		NX_O14770
Human Synonyms		HsT18361, MRG1
Human Chr (Location)		15q14; chr15:36891021-37101299 (-)  GRCh38

Alleles and phenotypes

All alleles(14) : Gene trapped(13) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	eye development, multicellular organismal development, ...
Component	nucleus
Function	DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (85 records)

Data Summary: Results (248)    Tissues (228)    Images (40)
Theiler Stages: 2, 3, 4, 5, 10, 11, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	220
Northern blot	11
RT-PCR	17

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(1) cDNA(34) Primer pair(3) Other(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000015219 (Evidence)
Ensembl Gene Model	ENSMUSG00000027210 (Evidence)
Entrez Gene	17536 (Evidence)
DFCI	TC1575848, TC1589889, TC1590536, TC1594077, TC1597283, TC1617509, TC1653265, TC1705791
DoTS	DT.101367941, DT.101385872, DT.110660615, DT.110660634, DT.91334926, DT.91582994, DT.91596612, DT.94167178, DT.97333354, DT.97336010, DT.97336017
NIA Mouse Gene Index	U023195, U250375
Consensus CDS Project	CCDS16568.1, CCDS50664.1, CCDS50665.1, CCDS50666.1, CCDS50667.1, CCDS50668.1
International Mouse Knockout Project Status	Meis2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015219	VEGA Gene Model | MGI Sequence Detail	202776	C57BL/6J
transcript	OTTMUST00000036124	VEGA | MGI Sequence Detail	2831	Not Applicable
polypeptide	OTTMUSP00000016227	VEGA | MGI Sequence Detail	477	Not Applicable

All sequences(140) RefSeq(32) UniProt(8)

Polymorphisms

RFLP(2) : SNPs within 2kb(1261 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR008422	Homeobox KN domain
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000010317	homeobox protein Meis2

References

(Earliest) J:28316 Bouillet P, et al., Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
(Latest) J:208353 Kondo T, et al., Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer. Dev Cell. 2014 Jan 13;28(1):94-101
All references(121)

Other accession IDs

MGD-MRK-36505, MGD-MRK-37608, MGI:107925, MGI:2442113