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Meis2 Gene Detail
Summary
  • Symbol
    Meis2
  • Name
    Meis homeobox 2
  • Synonyms
    A430109D20Rik, Meis2, Mrg1, Stra10
  • Feature Type
    protein coding gene
  • IDs
    MGI:108564
    NCBI Gene: 17536
  • Gene Overview
    MyGene.info: MEIS2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:115863064-116065839 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      202776 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 58.28 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MEIS2, Meis homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MEIS2, Meis homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPCMR, HsT18361, MRG1
  • Links
    NCBI Gene ID: 4212
    neXtProt AC: NX_O14770
    UniProt: O14770

  • Chr Location
    15q14; chr15:36891021-37101299 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 7846
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MEIS2
  • Gene Tree
    Meis2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    21 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display early fetal lethality with hemorrhaging, persistent truncus arteriosis, absence of cardic valves and defects in other neural crest cell derived tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    20
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    455
  • Tissues
    339
  • cDNA Data
    37
  • Literature Summary
    103
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015219 VEGA Gene Model | MGI Sequence Detail 202776 C57BL/6J ±  kb
transcript OTTMUST00000036124 VEGA | MGI Sequence Detail 2831 Not Applicable  
polypeptide OTTMUSP00000016227 VEGA | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1258 from dbSNP Build 142
  • RFLP
    2
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    Genomic 1
    cDNA 37
    Primer pair 5
    Other 7

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-36505, MGD-MRK-37608, MGI:107925, MGI:2442113
References
more
  • Summaries
    All 145
    Developmental Gene Expression 103
    Gene Ontology 15
    Phenotypes 11
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:256526 Kuerbitz J, et al., Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes. J Neurosci. 2018 Jan 31;38(5):1160-1177
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory