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Gene Detail
kinesin family member 1B
Synonyms A530096N05Rik, D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, mKIAA0591, N-3 kinesin
Feature Type protein coding gene
Genetic Map
Chromosome 4
79.05 cM, cytoband E
Detailed Genetic Map ± 1 cM

Mapping data(6)
Sequence Map
Chr4:149176319-149307693 bp, - strand
From VEGA annotation of GRCm38

  131375 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:99835  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinesin protein, Kif1A/Kif1B types
Gene Tree: Kif1b

Human Homolog KIF1B, kinesin family member 1B
NCBI Gene ID 23095
neXtProt AC  NX_O60333
Human Synonyms  CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1
Human Chr (Location)  1p36.2; chr1:10210706-10381603 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human KIF1B
alleles, and
All mutations/alleles(52) : Gene trapped(48) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for a targeted null mutation exhibit reduced brain size, elevated pain threshold, and neonatal death from apnea. Heterozygotes exhibit impaired synaptic vesicle precursor transport and progressive muscle weakness.
Human Diseases Modeled Using Mouse Kif1b (1)    Alleles Annotated to Human Diseases(1)   
Kif1b interacts with 460 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (29 annotations)
Process anterograde axon cargo transport, ATP catabolic process, ...
Component cell, cytoplasm, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Literature Summary: (17 records)
Data Summary: Results (307)    Tissues (92)    Images (44)
Theiler Stages: 15, 17, 18, 19, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 274
Northern blot 15
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(37) Genomic(4) cDNA(30) Primer pair(3)
Microarray probesets(14)
Other database
VEGA Gene ModelOTTMUSG00000010170 (Evidence)
Ensembl Gene ModelENSMUSG00000063077 (Evidence)
Entrez Gene16561 (Evidence)
DFCITC1577322, TC1581054, TC1598014, TC1598149, TC1607671, TC1611617, TC1647541, TC1688579
DoTSDT.101168789, DT.101241064, DT.101264796, DT.110803531, DT.110803540, DT.87069547, DT.87069549, DT.91581921, DT.94159649, DT.97370963
NIA Mouse Gene IndexU025798
Consensus CDS ProjectCCDS18956.1, CCDS18957.1, CCDS71521.1
International Mouse Knockout Project StatusKif1b
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010170 VEGA Gene Model | MGI Sequence Detail 131375 C57BL/6J ±  kb
transcript OTTMUST00000023642 VEGA | MGI Sequence Detail 10233 Not Applicable 
polypeptide OTTMUSP00000010804 VEGA | MGI Sequence Detail 1816 Not Applicable 

For the selected sequences
All sequences(130) RefSeq(34) UniProt(7)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(887 from dbSNP Build 137)
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR022164 Kinesin-like
InterPro IPR001752 Kinesin, motor domain
InterPro IPR019821 Kinesin, motor region, conserved site
InterPro IPR022140 Kinesin protein 1B
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000009296 kinesin-like protein KIF1B
References (Earliest) J:113711 Matthews RH, et al., Biphasic kinetic plots and specific analogs distinguishing and describing amino acid transport sites in S37 ascites tumor cells. Biochim Biophys Acta. 1975 Jun 25;394(2):182-92
(Latest) J:197462 Dillman AA, et al., mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013 Apr;16(4):499-506
All references(67)
Disease annotation references (1)
accession IDs
MGD-MRK-35098, MGD-MRK-37469, MGI:106641, MGI:2140281, MGI:2140318, MGI:2442923

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory