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Kif1b
Gene Detail
Symbol

Name
ID
Kif1b
kinesin family member 1B
MGI:108426
Synonyms
A530096N05Rik, D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, mKIAA0591, N-3 kinesin
Feature Type
protein coding gene
Genetic Map
Chromosome 4
79.05 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:149176319-149307693 bp, - strand
From VEGA annotation of GRCm38

  131375 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:99835  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinesin protein, Kif1A/Kif1B types
Gene Tree: Kif1b

Human
homologs
Human Homolog KIF1B, kinesin family member 1B
NCBI Gene ID 23095
neXtProt AC  NX_O60333
Human Synonyms  CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1
Human Chr (Location)  1p36.2; chr1:10210706-10381603 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human KIF1B
Mutations,
alleles, and
phenotypes
All mutations/alleles(52) : Gene trapped(48) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit reduced brain size, elevated pain threshold, and neonatal death from apnea. Heterozygotes exhibit impaired synaptic vesicle precursor transport and progressive muscle weakness.
 
Human Diseases Modeled Using Mouse Kif1b (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Kif1b interacts with 460 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process anterograde axon cargo transport, ATP catabolic process, ...
Component cell, cytoplasm, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (307)    Tissues (92)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 274
Northern blot 15
RT-PCR 18
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(4) cDNA(30) Primer pair(3)
Microarray probesets(14)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010170 VEGA Gene Model | MGI Sequence Detail 131375 C57BL/6J ±  kb
transcript OTTMUST00000023642 VEGA | MGI Sequence Detail 10233 Not Applicable 
polypeptide OTTMUSP00000010804 VEGA | MGI Sequence Detail 1816 Not Applicable 

For the selected sequences
All sequences(130) RefSeq(34) UniProt(7)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(887 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR022164 Kinesin-like
InterPro IPR001752 Kinesin, motor domain
InterPro IPR019821 Kinesin, motor region, conserved site
InterPro IPR022140 Kinesin protein 1B
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000009296 kinesin-like protein KIF1B
References
(Earliest) J:113711 Matthews RH, et al., Biphasic kinetic plots and specific analogs distinguishing and describing amino acid transport sites in S37 ascites tumor cells. Biochim Biophys Acta. 1975 Jun 25;394(2):182-92
(Latest) J:197462 Dillman AA, et al., mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013 Apr;16(4):499-506
All references(67)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35098, MGD-MRK-37469, MGI:106641, MGI:2140281, MGI:2140318, MGI:2442923

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory