Phenotypes Associated with This Genotype

Genotype
MGI:2387931

• Allelic Composition: Kif1b^tm1Noh/Kif1b⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:69772 )

• staggering; onset at approximately one year of age; progressive

impaired coordination ( J:69772 )

• at 12 months of age, impairment was observed in a rotarod test and a balance beam test

muscle

progressive muscle weakness ( J:69772 )

• at 12 months of age, evoked compound action potential amplitudes were significantly reduced; the conduction velocity was unaffected

nervous system

abnormal axonal transport ( J:69772 )

• impaired vesicle transport in peripheral nerves

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Charcot-Marie-Tooth disease type 2A1		DOID:0110154	OMIM:118210	J:69772