Alx4
Gene Detail

Symbol Name ID

Alx4 aristaless-like homeobox 4 MGI:108359

Synonyms

Aristaless-like 4

Feature Type

protein coding gene

Genetic Map

Chromosome 2

51.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr2:93642384-93681339 bp, + strand From VEGA annotation of GRCm38   38956 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7229  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: homeotic protein Hox B3
Gene Tree: Alx4

Human homologs

Human Homolog		ALX4, ALX homeobox 4
NCBI Gene ID		60529
neXtProt AC		NX_Q9H161
Human Synonyms		FND2
Human Chr (Location)		11p11.2; chr11:44282278-44331716 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ALX4

Alleles and phenotypes

All alleles(5) : Targeted(1) Spontaneous(1) Chemically induced(3)
 

Depending on genetic background mutant mice may show preaxial polydactyly and other skeletal alterations, transitory alopecia, ventral body wall defects and male sterility. Homozygous mice of one allele die prenatally.

 

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	anterior/posterior pattern specification, digestive tract development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, HMG box domain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (71 records)
Data Summary: Results (293)    Tissues (210)    Images (65)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	274
Northern blot	12
Western blot	1
RT-PCR	6

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(2) cDNA(29) Primer pair(3) Other(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000014563 (Evidence)
Ensembl Gene Model	ENSMUSG00000040310 (Evidence)
Entrez Gene	11695 (Evidence)
UniGene	389389
DFCI	TC1595674
DoTS	DT.87063642, DT.91446563
NIA Mouse Gene Index	U002148
Consensus CDS Project	CCDS16455.1
International Mouse Knockout Project Status	Alx4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014563	VEGA Gene Model | MGI Sequence Detail	38956	C57BL/6J
transcript	OTTMUST00000034529	VEGA | MGI Sequence Detail	5253	Not Applicable
polypeptide	OTTMUSP00000015453	VEGA | MGI Sequence Detail	399	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(196 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR003654	OAR domain
Protein Ontology	PR:000003980	homeobox protein aristaless-like 4

References

(Earliest) J:34255 Strong LC, et al., A new Luxoid mutant in mice. J Hered. 1956;47:277-84
(Latest) J:193110 Griffin JN, et al., Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 1;374(1):185-97
All references(128)

Other accession IDs

MGD-MRK-11896, MGD-MRK-37399, MGI:96834