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Alx4 Gene Detail
Summary
  • Symbol
    Alx4
  • Name
    aristaless-like homeobox 4
  • Synonyms
    Aristaless-like 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:108359
    NCBI Gene: 11695
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:93472779-93511686 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 51.62 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1066 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108359
 protein coding gene Chr2:93472729-93511686 (+)
129S1/SvImJ ENSMUSG00200052573
 protein coding gene Chr2:90390248-90427650 (+)
A/J ENSMUSG00195051307
 protein coding gene Chr2:90523876-90562964 (+)
AKR/J ENSMUSG00220051793
 protein coding gene Chr2:90321600-90360725 (+)
BALB/cJ ENSMUSG00180054777
 protein coding gene Chr2:90423448-90462580 (+)
C3H/HeJ ENSMUSG00175052503
 protein coding gene Chr2:90686002-90725120 (+)
C57BL/6NJ ENSMUSG00215053474
 protein coding gene Chr2:90517459-90556423 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023989
 protein coding gene Chr2:87766781-87805825 (+)
CAST/EiJ ENSTCUG00005050405
 protein coding gene Chr2:89941961-89980903 (+)
CBA/J ENSMUSG00210036452
 protein coding gene Chr2:90695845-90734977 (+)
DBA/2J ENSMUSG00185057004
 protein coding gene Chr2:90419759-90458895 (+)
FVB/NJ ENSMUSG00205050632
 protein coding gene Chr2:89708026-89747154 (+)
JF1/MsJ ENSUMUG00000032493
 protein coding gene Chr2:90254652-90293413 (+)
LP/J ENSMUSG00230044791
 protein coding gene Chr2:92170394-92209526 (+)
NOD/ShiLtJ ENSMUSG00190037604
 protein coding gene Chr2:90498368-90537487 (+)
NZO/HlLtJ ENSMUSG00225052125
 protein coding gene Chr2:100085478-100122846 (+)
PWK/PhJ ENSLUMG00010050890
 protein coding gene Chr2:90217026-90255925 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005053065
 protein coding gene Chr2:90223456-90262443 (+)



Homology
more
  • Human Ortholog
    ALX4, ALX homeobox 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALX4, ALX homeobox 4
  • Synonyms
    CRS5, FND2
  • Links
    NCBI Gene ID: 60529
    UniProt: Q9H161

  • Chr Location
    11p11.2; chr11:44260440-44310139 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Alx4 mouse models; 8 with human ALX4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 6 alleles in 9 genetic backgrounds
    63 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Depending on genetic background mutant mice may show preaxial polydactyly and other skeletal alterations, transitory alopecia, ventral body wall defects and male sterility. Homozygous mice of one allele die prenatally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1035
  • Tissues
    268
  • cDNA Data
    28
  • Literature Summary
    112
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11695 NCBI Gene Model | MGI Sequence Detail 38908 C57BL/6J ±  kb
    transcript NM_007442 RefSeq | MGI Sequence Detail 5203 ZRU/MplStud  
    polypeptide O35137 UniProt | EBI | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 2
      cDNA 31
      Primer pair 5
      Other 23
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11896, MGD-MRK-37399, MGI:96834
    References
    more
    • Summaries
      All 179
      Developmental Gene Expression 112
      Diseases 1
      Gene Ontology 15
      Phenotypes 45
    • Earliest
      J:34255 Strong LC, et al., A new Luxoid mutant in mice. J Hered. 1956;47(6):277-84
    • Latest
      J:362028 Adhikari N, et al., Twist1 Acts Upstream of the Dlx5-Hand2 Pathway to Pattern the Mammalian Jaw. J Dent Res. 2025 Mar;104(3):310-319
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory