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Alx4
Gene Detail
Symbol

Name
ID
Alx4
aristaless-like homeobox 4
MGI:108359
Synonyms
Aristaless-like 4
Feature Type
protein coding gene
Genetic Map
Chromosome 2
51.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr2:93642384-93681339 bp, + strand
From VEGA annotation of GRCm38

  38956 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7229  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ALX4
Protein SuperFamily: homeotic protein Hox B3
Gene Tree: Alx4

Human
homologs
ALX4, ALX homeobox 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 60529
neXtProt AC: NX_Q9H161

Human Synonyms: CRS5, FND2

Human Chr (Location): 11p11.2; chr11:44260438-44319220 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human ALX4

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(2) Chemically induced (other)(2) Spontaneous(1) Targeted(3)
Genomic Mutations involving Alx4 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Depending on genetic background mutant mice may show preaxial polydactyly and other skeletal alterations, transitory alopecia, ventral body wall defects and male sterility. Homozygous mice of one allele die prenatally.
 
Interactions
Alx4 interacts with 433 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process anterior/posterior pattern specification, digestive tract development, ...
Component nucleus, transcription factor complex
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (82 records)
Data Summary: Results (309)    Tissues (216)    Images (71)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 290
Northern blot 12
Western blot 1
RT-PCR 6
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ALX4 ZFIN alx4a, alx4b    NEW 
Molecular
reagents
All nucleic(41) Genomic(2) cDNA(30) Primer pair(3) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000014563 (Evidence)
Ensembl Gene Model ENSMUSG00000040310 (Evidence)
Entrez Gene 11695 (Evidence)
UniGene 389389
DFCI TC1595674
DoTS DT.91446563, DT.87063642
NIA Mouse Gene Index U002148
Consensus CDS Project CCDS16455.1
International Mouse Phenotyping Consortium Status Alx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014563 VEGA Gene Model | MGI Sequence Detail 38956 C57BL/6J ±  kb
transcript OTTMUST00000034529 VEGA | MGI Sequence Detail 5253 Not Applicable 
polypeptide OTTMUSP00000015453 VEGA | MGI Sequence Detail 399 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(3) UniProt(2)
Polymorphisms
SNPs within 2kb(290 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000003980 homeobox protein aristaless-like 4
References
(Earliest) J:34255 Strong LC, et al., A new Luxoid mutant in mice. J Hered. 1956;47:277-84
(Latest) J:219584 Zhulyn O, et al., Sufu and Kif7 in limb patterning and development. Dev Dyn. 2015 Mar;244(3):468-78
All references(139)
Other
accession IDs
MGD-MRK-11896, MGD-MRK-37399, MGI:96834

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory