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Alx4
Gene Detail
 Symbol
Name
ID
Alx4
aristaless-like homeobox 4
MGI:108359
Synonyms Aristaless-like 4
Feature Type protein coding gene
Genetic Map
Chromosome 2
51.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr2:93642384-93681339 bp, + strand
From VEGA annotation of GRCm38

  38956 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7229  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: homeotic protein Hox B3
Gene Tree: Alx4

Human
homologs
Human Homolog ALX4, ALX homeobox 4
NCBI Gene ID 60529
neXtProt AC  NX_Q9H161
Human Synonyms  CRS5, FND2
Human Chr (Location)  11p11.2; chr11:44260728-44310185 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human ALX4
Alleles
and
phenotypes
All alleles(6) : Targeted(1) Spontaneous(1) Chemically induced(4)
 
Depending on genetic background mutant mice may show preaxial polydactyly and other skeletal alterations, transitory alopecia, ventral body wall defects and male sterility. Homozygous mice of one allele die prenatally.
 
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process anterior/posterior pattern specification, digestive tract development, ...
Component nucleus, transcription factor complex
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (74 records)
Data Summary: Results (307)    Tissues (215)    Images (69)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 288
Northern blot 12
Western blot 1
RT-PCR 6
cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(40) Genomic(2) cDNA(30) Primer pair(3) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000014563 (Evidence)
Ensembl Gene ModelENSMUSG00000040310 (Evidence)
Entrez Gene11695 (Evidence)
UniGene389389
DFCITC1595674
DoTSDT.87063642, DT.91446563
NIA Mouse Gene IndexU002148
Consensus CDS ProjectCCDS16455.1
International Mouse Knockout Project StatusAlx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014563 VEGA Gene Model | MGI Sequence Detail 38956 C57BL/6J ±  kb
transcript OTTMUST00000034529 VEGA | MGI Sequence Detail 5253 Not Applicable 
polypeptide OTTMUSP00000015453 VEGA | MGI Sequence Detail 399 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(3) UniProt(2)
Polymorphisms SNPs within 2kb(290 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000003980 homeobox protein aristaless-like 4
References (Earliest) J:34255 Strong LC, et al., A new Luxoid mutant in mice. J Hered. 1956;47:277-84
(Latest) J:203059 Xu B, et al., Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19438-43
All references(132)
Other
accession IDs
MGD-MRK-11896, MGD-MRK-37399, MGI:96834

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory