Phenotypes Associated with This Genotype

Genotype
MGI:5695543

• Allelic Composition: Alx4^Lst-2J/Alx4^Lst-2J
• Genetic Background: C57BL/6J-Alx4^Lst-2J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

polydactyly ( J:223288 )

• homozygotes have polydactyly on all four feet

skeleton

abnormal neurocranium morphology ( J:223288 )

abnormal frontal bone morphology ( J:223288 )

• homozygotes can have large bulges at the anterior skull, above the snout, indicating defective calvaria formation

integument

alopecia ( J:223288 )

• homozygotes have dorsal alopecia

craniofacial

abnormal neurocranium morphology ( J:223288 )

abnormal frontal bone morphology ( J:223288 )

• homozygotes can have large bulges at the anterior skull, above the snout, indicating defective calvaria formation

short snout ( J:223288 )

vision/eye

cataract ( J:223288 )

ocular hypertelorism ( J:223288 )

• craniofacial abnormalities of homozygotes includes wide-set eyes

eyelids open at birth ( J:223288 )

growth/size/body

short snout ( J:223288 )

mortality/aging

perinatal lethality, incomplete penetrance ( J:223288 )

• litters from heterozgyous intercrosses often have pups that die perinatally, but a few homozygotes do survive to adulthood

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
parietal foramina		DOID:0060285	OMIM:168500 OMIM:609566 OMIM:609597	J:223288