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Symbol
Name
ID

Alx4
aristaless-like homeobox 4
MGI:108359

Phenotype annotations related to craniofacial

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Low anterior hairline

Scalp tenderness

Frontal bossing

Prominent occiput

Parietal foramina

Biparietal narrowing

Brachycephaly

Brachyturricephaly

Calvarial skull defect

Craniosynostosis

Coronal craniosynostosis

Bicoronal synostosis

Unicoronal synostosis

Left unicoronal synostosis

Right unicoronal synostosis

Lambdoidal craniosynostosis

Pansynostosis

Sagittal craniosynostosis

Dolichocephaly

Scaphocephaly

Anterior plagiocephaly

Trigonocephaly

Turricephaly

Oxycephaly

Micrognathia

Retrognathia

Hypoplasia of the maxilla

Malar flattening

Shallow orbits

Abnormal posterior cranial fossa morphology

Microcephaly

Macrocephaly

Metopic synostosis

Wormian bones

Wide anterior fontanel

Encephalocele

Occipital encephalocele

Congenital craniofacial dysostosis

Midface retrusion

Prominent forehead

Broad philtrum

Cleft upper lip

Cleft lip

Cleft soft palate

Cleft palate

High palate

Narrow palate

Conical tooth

Supernumerary tooth

Dental malocclusion

Widely spaced teeth

Broad columella

Anteverted nares

Cleft ala nasi

Depressed nasal ridge

Wide nasal ridge

Bifid nasal tip

Depressed nasal tip

Depressed nasal bridge

Wide nasal bridge

Aplasia of the nasal bone

Sparse eyebrow

Sparse eyelashes

Blepharophimosis

Short palpebral fissure

Downslanted palpebral fissures

Upslanted palpebral fissure

Telecanthus

Tessier number 13 facial cleft

Disease(s) Associated with ALX4

craniosynostosis

frontonasal dysplasia 2

parietal foramina

Mouse Phenotypes		craniofacial phenotype	abnormal neurocranium morphology	abnormal frontal bone morphology	abnormal parietal bone morphology	small parietal bone	short snout	upturned snout
Availability	Mouse Genotype	craniofacial phenotype	abnormal neurocranium morphology	abnormal frontal bone morphology	abnormal parietal bone morphology	small parietal bone	short snout	upturned snout
	Alx4^Lst-2J/Alx4^Lst-2J	*
	Alx4^m1Btlr/Alx4^m1Btlr
	Alx4^M1Yzcm/Alx4^M1Yzcm
	Alx4^tm1Rwi/Alx4^tm1Rwi
	Alx4^Lst-2J/Alx4⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23