Smad2
Gene Detail

Symbol Name ID

Smad2 SMAD family member 2 MGI:108051

Synonyms

7120426M23Rik, Madh2, Madr2, Smad 2

Feature Type

protein coding gene

Genetic Map

Chromosome 18

51.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr18:76241580-76305731 bp, + strand From VEGA annotation of GRCm38   64152 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Smad protein
Gene Tree: Smad2

Human homologs

Human Homolog		SMAD2, SMAD family member 2
NCBI Gene ID		4087
neXtProt AC		NX_Q15796
Human Synonyms		hMAD-2, hSMAD2, JV18, JV18-1, MADH2, MADR2
Human Chr (Location)		18q21.1; chr18:45359466-45457517 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(45) : Targeted(22) Gene trapped(22) Chemically induced(1)
 

Homozygous embryos die at day 6.5-8.5 with multiple defects, including failed gastrulation, lack of mesoderm, visceral endoderm dysfunction and failure to form anterior-posterior axis. Heterozygotes may show gastrulation defects and lack mandible or eyes.

 
Phenotype Images(9)

Gene Ontology (GO) classifications

All GO classifications: (95 annotations)

Process	activin receptor signaling pathway, anterior/posterior pattern specification, ...
Component	activin responsive factor complex, cytoplasm, ...
Function	activating transcription factor binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (125 records)
Data Summary: Results (439)    Tissues (289)    Images (93)
Theiler Stages: 2, 3, 4, 5, 7, 8, 9, 10, 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	181
RNA in situ	213
Northern blot	7
Western blot	9
RT-PCR	29

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(3) cDNA(21) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000036536 (Evidence)
Ensembl Gene Model	ENSMUSG00000024563 (Evidence)
Entrez Gene	17126 (Evidence)
DFCI	TC1576658, TC1598688, TC1606782
DoTS	DT.101218049, DT.101311430, DT.491923, DT.97350196
NIA Mouse Gene Index	U068949, U141140
Consensus CDS Project	CCDS29350.1
International Mouse Knockout Project Status	Smad2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036536	VEGA Gene Model | MGI Sequence Detail	64152	C57BL/6J
transcript	OTTMUST00000093678	VEGA | MGI Sequence Detail	2857	Not Applicable
polypeptide	OTTMUSP00000052023	VEGA | MGI Sequence Detail	467	Not Applicable

All sequences(65) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(303 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013790	Dwarfin
InterPro	IPR003619	MAD homology 1, Dwarfin-type
InterPro	IPR013019	MAD homology, MH1
InterPro	IPR001132	SMAD domain, Dwarfin-type
InterPro	IPR017855	SMAD domain-like
InterPro	IPR008984	SMAD/FHA domain
Protein Ontology	PR:000000364	smad2

References

(Earliest) J:34765 Baker JC, et al., A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev. 1996 Aug 1;10(15):1880-9
(Latest) J:191052 Wu Q, et al., Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells. Development. 2013 Jan;140(2):291-300
All references(243)

Other accession IDs

MGD-MRK-37087, MGI:2442937