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Smad2
Gene Detail
 Symbol
Name
ID
Smad2
SMAD family member 2
MGI:108051
Synonyms 7120426M23Rik, Madh2, Madr2, Smad 2
Feature Type protein coding gene
Genetic Map
Chromosome 18
51.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr18:76241580-76305731 bp, + strand
From VEGA annotation of GRCm38

  64152 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Smad protein
Gene Tree: Smad2

Human
homologs
Human Homolog SMAD2, SMAD family member 2
NCBI Gene ID 4087
neXtProt AC  NX_Q15796
Human Synonyms  hMAD-2, hSMAD2, JV18, JV18-1, MADH2, MADR2
Human Chr (Location)  18q21.1; chr18:47833095-47931193 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(45) : Chemically induced (ENU)(1) Gene trapped(22) Targeted(22)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous embryos die at day 6.5-8.5 with multiple defects, including failed gastrulation, lack of mesoderm, visceral endoderm dysfunction and failure to form anterior-posterior axis. Heterozygotes may show gastrulation defects and lack mandible or eyes.
 
Phenotype Images(9)
Interactions
Smad2 interacts with 221 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (103 annotations)
Process activin receptor signaling pathway, anterior/posterior pattern specification, ...
Component activin responsive factor complex, cell, ...
Function activating transcription factor binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (140 records)
Data Summary: Results (547)    Tissues (307)    Images (121)
Theiler Stages: 2, 3, 4, 5, 7, 8, 9, 10, 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 225
RNA in situ 213
Northern blot 7
Western blot 60
RT-PCR 42
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(3) cDNA(21) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036536 (Evidence)
Ensembl Gene ModelENSMUSG00000024563 (Evidence)
Entrez Gene17126 (Evidence)
DFCITC1576658, TC1598688, TC1606782
DoTSDT.101218049, DT.101311430, DT.491923, DT.97350196
NIA Mouse Gene IndexU068949, U141140
Consensus CDS ProjectCCDS29350.1
International Mouse Knockout Project StatusSmad2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036536 VEGA Gene Model | MGI Sequence Detail 64152 C57BL/6J ±  kb
transcript OTTMUST00000093678 VEGA | MGI Sequence Detail 2857 Not Applicable 
polypeptide OTTMUSP00000052023 VEGA | MGI Sequence Detail 467 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(8) UniProt(6)
Polymorphisms SNPs within 2kb(431 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013790 Dwarfin
InterPro IPR003619 MAD homology 1, Dwarfin-type
InterPro IPR013019 MAD homology, MH1
InterPro IPR001132 SMAD domain, Dwarfin-type
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000000364 smad2
References (Earliest) J:34765 Baker JC, et al., A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev. 1996 Aug 1;10(15):1880-9
(Latest) J:210699 Fortin J, et al., Follicle-stimulating hormone synthesis and fertility are intact in mice lacking SMAD3 DNA binding activity and SMAD2 in gonadotrope cells. FASEB J. 2014 Mar;28(3):1474-85
All references(269)
Other
accession IDs
MGD-MRK-37087, MGI:2442937

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory