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Mdm4 Gene Detail
Summary
  • Symbol
    Mdm4
  • Name
    transformed mouse 3T3 cell double minute 4
  • Synonyms
    4933417N07Rik, Mdmx
  • Feature Type
    protein coding gene
  • IDs
    MGI:107934
    NCBI Gene: 17248
  • Gene Overview
    MyGene.info: MDM4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:132959484-133030561 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71078 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.75 cM, cytoband G-G
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    MDM4, MDM4, p53 regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MDM4, MDM4, p53 regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HDMX, MDMX, MRP1
  • Links
    NCBI Gene ID: 4194
    neXtProt AC: NX_O15151
    UniProt: O15151

  • Chr Location
    1q32.1; chr1:204516379-204558120 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Mdm4 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 9 alleles in 11 genetic backgrounds
    57 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit embryonic lethality, decreased cellular proliferation, and abnormal nervous system development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000049638 VEGA Gene Model | MGI Sequence Detail 71078 C57BL/6J ±  kb
    transcript OTTMUST00000126454 VEGA | MGI Sequence Detail 1914 Not Applicable  
    polypeptide OTTMUSP00000068376 VEGA | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      675 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 23
      Primer pair 1
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-36514, MGI:1921697, MGI:2138095, MGI:2138388, MGI:2138425, MGI:2138465, MGI:2138710
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 7
      Phenotypes 57
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:261424 Huang Q, et al., MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3368-E3377

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory