About   Help   FAQ
Mdm4 Gene Detail
Summary
  • Symbol
    Mdm4
  • Name
    transformed mouse 3T3 cell double minute 4
  • Synonyms
    4933417N07Rik, Mdmx
  • Feature Type
    protein coding gene
  • IDs
    MGI:107934
    NCBI Gene: 17248
  • Gene Overview
    MyGene.info: MDM4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:132959484-133030561 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71078 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.75 cM, cytoband G-G
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    MDM4, MDM4, p53 regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MDM4, MDM4, p53 regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HDMX, MDMX, MRP1
  • Links
    NCBI Gene ID: 4194
    neXtProt AC: NX_O15151
    UniProt: O15151

  • Chr Location
    1q32.1; chr1:204516379-204558120 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Mdm4 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 9 alleles in 11 genetic backgrounds
    57 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit embryonic lethality, decreased cellular proliferation, and abnormal nervous system development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049638 VEGA Gene Model | MGI Sequence Detail 71078 C57BL/6J ±  kb
transcript OTTMUST00000126454 VEGA | MGI Sequence Detail 1914 Not Applicable  
polypeptide OTTMUSP00000068376 VEGA | MGI Sequence Detail 490 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    675 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 1
    cDNA 22
    Primer pair 1
    Other 2

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-36514, MGI:1921697, MGI:2138095, MGI:2138388, MGI:2138425, MGI:2138465, MGI:2138710
References
more
  • Summaries
    All 93
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 7
    Phenotypes 53
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:241797 Xiong S, et al., The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis. J Pathol. 2017 Mar;241(4):501-510

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/07/2017
MGI 6.11
The Jackson Laboratory