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Pip5k1b
Gene Detail
 Symbol
Name
ID
Pip5k1b
phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
MGI:107930
Synonyms Pipk5b
Feature Type protein coding gene
Genetic Map
Chromosome 19
19.44 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:24294794-24555872 bp, - strand
From VEGA annotation of GRCm38

  261079 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:100644  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphatidylinositol-4-phosphate 5-kinase type II alpha
Gene Tree: Pip5k1b

Human
homologs
Human Homolog PIP5K1B, phosphatidylinositol-4-phosphate 5-kinase, type I, beta
NCBI Gene ID 8395
neXtProt AC  NX_O14986
Human Synonyms  MSS4, STM7
Human Chr (Location)  9q13; chr9:68705332-69009176 (+)  GRCh38
Alleles
and
phenotypes
All alleles(22) : Gene trapped(18) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit enhanced passive cutaneous and systemic anaphylaxis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process phosphatidylinositol metabolic process, phosphatidylinositol phosphorylation, ...
Component membrane, uropod
Function 1-phosphatidylinositol-4-phosphate 5-kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (186)    Tissues (133)    Images (8)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 181
Northern blot 1
RT-PCR 4
cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) cDNA(25) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000031802 (Evidence)
Ensembl Gene ModelENSMUSG00000024867 (Evidence)
Entrez Gene18719 (Evidence)
UniGene217214
DFCITC1580526, TC1590827
DoTSDT.101341641, DT.530826, DT.94140730
NIA Mouse Gene IndexU038927
EC2.7.1.68
Consensus CDS ProjectCCDS37940.1
International Mouse Knockout Project StatusPip5k1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031802 VEGA Gene Model | MGI Sequence Detail 261079 C57BL/6J ±  kb
transcript OTTMUST00000078826 VEGA | MGI Sequence Detail 2573 Not Applicable 
polypeptide OTTMUSP00000041954 VEGA | MGI Sequence Detail 539 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(3777 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
InterPro IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
InterPro IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
InterPro IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
InterPro IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
Protein Ontology PR:000012745 phosphatidylinositol 4-phosphate 5-kinase type-1 beta
References (Earliest) J:35632 Ishihara H, et al., Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1996 Sep 27;271(39):23611-4
(Latest) J:202701 van den Bout I, et al., Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction. Biochem J. 2013 Nov 1;455(3):347-58
All references(61)
Other
accession IDs
MGD-MRK-36510, MGI:2147609

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory