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Fut7 Gene Detail
Summary
  • Symbol
    Fut7
  • Name
    fucosyltransferase 7
  • Synonyms
    FTVII, Fuc-TVII, FucT-VII
  • Feature Type
    protein coding gene
  • IDs
    MGI:107692
    NCBI Gene: 14347
  • Gene Overview
    MyGene.info: FUT7
Location & Maps
more
  • Sequence Map
    Chr2:25423267-25426374 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3108 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.25 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FUT7, fucosyltransferase 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FUT7, fucosyltransferase 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FucT-VII
  • Links
    NCBI Gene ID: 2529
    neXtProt AC: NX_Q11130

  • Chr Location
    9q34.3; chr9:137030174-137032840 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Targeted
    6
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene are superficially normal. However, abnormalities are found in immune cell function and lymph node morphology. Redeuced tumor metastasis is also seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012106 VEGA Gene Model | MGI Sequence Detail 3108 C57BL/6J ±  kb
transcript OTTMUST00000028833 VEGA | MGI Sequence Detail 1990 Not Applicable  
polypeptide OTTMUSP00000013044 VEGA | MGI Sequence Detail 342 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    39 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000030635 alpha-(1,3)-fucosyltransferase FUT7
  • EC
  • InterPro Domains
    IPR031481 Fucosyltransferase, N-terminal
    IPR001503 Glycosyl transferase family 10
Molecular
Reagents
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  • All nucleic 17
    Genomic 3
    cDNA 13
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-36268, MGI:2139093
References
more
  • Summaries
    All 79
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 49
  • Earliest
    J:32202 Smith PL, et al., Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands. J Biol Chem. 1996 Apr 5;271(14):8250-9
  • Latest
    J:213922 Sarraj B, et al., Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12145-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory