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Fut7
Gene Detail
 Symbol
Name
ID
Fut7
fucosyltransferase 7
MGI:107692
Synonyms FTVII, Fuc-TVII, FucT-VII
Feature Type protein coding gene
Genetic Map
Chromosome 2
17.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:25423267-25426374 bp, + strand
From VEGA annotation of GRCm38

  3108 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3296  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: fucosyltransferase
Gene Tree: Fut7

Human
homologs
Human Homolog FUT7, fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
NCBI Gene ID 2529
neXtProt AC  NX_Q11130
Human Synonyms  FucT-VII
Human Chr (Location)  9q34.3; chr9:137030174-137032840 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene are superficially normal. However, abnormalities are found in immune cell function and lymph node morphology. Redeuced tumor metastasis is also seen.
 
Interactions
Fut7 interacts with 48 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, leukocyte migration involved in immune response, ...
Component Golgi apparatus, integral component of membrane, ...
Function 1,2-dihydroxy-phenanthrene glycosyltransferase activity, 1-phenanthrol glycosyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(3) cDNA(13) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000012106 (Evidence)
Ensembl Gene ModelENSMUSG00000036587 (Evidence)
Entrez Gene14347 (Evidence)
UniGene1203
DFCITC1586766, TC1675987
DoTSDT.101367179, DT.99855269
NIA Mouse Gene IndexU001492
EC2.4.1.-
Consensus CDS ProjectCCDS15772.1, CCDS50530.1
International Mouse Knockout Project StatusFut7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012106 VEGA Gene Model | MGI Sequence Detail 3108 C57BL/6J ±  kb
transcript OTTMUST00000028833 VEGA | MGI Sequence Detail 1990 Not Applicable 
polypeptide OTTMUSP00000013044 VEGA | MGI Sequence Detail 342 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(24) UniProt(4)
Polymorphisms SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001503 Glycosyl transferase, family 10
Protein Ontology PR:000030635 alpha-(1,3)-fucosyltransferase FUT7
References (Earliest) J:32202 Smith PL, et al., Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands. J Biol Chem. 1996 Apr 5;271(14):8250-9
(Latest) J:206967 Hoos A, et al., Metastatic growth progression caused by PSGL-1-mediated recruitment of monocytes to metastatic sites. Cancer Res. 2014 Feb 1;74(3):695-704
All references(80)
Other
accession IDs
MGD-MRK-36268, MGI:2139093

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory