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Nab2 Gene Detail
Summary
  • Symbol
    Nab2
  • Name
    Ngfi-A binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107563
    NCBI Gene: 17937
  • Gene Overview
    MyGene.info: NAB2
Location & Maps
more
  • Sequence Map
    Chr10:127660918-127668568 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7651 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.60 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NAB2, NGFI-A binding protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NAB2, NGFI-A binding protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MADER
  • Links
    NCBI Gene ID: 4665
    neXtProt AC: NX_Q15742

  • Chr Location
    12q13.3; chr12:57088894-57095476 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4353
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NAB2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Gene trapped
    18
  • Targeted
    6
  • Incidental Mutations
Homozygous null mice are viable and fertile with normal myelination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031880 VEGA Gene Model | MGI Sequence Detail 7651 C57BL/6J ±  kb
transcript OTTMUST00000079042 VEGA | MGI Sequence Detail 2582 Not Applicable  
polypeptide OTTMUSP00000042122 VEGA | MGI Sequence Detail 525 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    21 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 16
    Genomic 3
    cDNA 12
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-36135, MGI:2143612
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:33567 Svaren J, et al., NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol Cell Biol. 1996 Jul;16(7):3545-53
  • Latest
    J:156017 Yokoyama S, et al., A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory