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Notch4 Gene Detail
Summary
  • Symbol
    Notch4
  • Name
    notch 4
  • Synonyms
    Int3, Int-3, N4
  • Feature Type
    protein coding gene
  • IDs
    MGI:107471
    NCBI Gene: 18132
  • Gene Overview
    MyGene.info: NOTCH4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:34564268-34588503 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24236 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.15 cM
  • Mapping Data
    18 experiments
Homology
more
  • Human Ortholog
    NOTCH4, notch 4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    NOTCH4, notch 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    INT3
  • Links
    NCBI Gene ID: 4855
    neXtProt AC: NX_Q99466
    UniProt: Q99466

  • Chr Location
    6p21.32; chr6:32194843-32224067 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Notch4 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 6 alleles in 6 genetic backgrounds
    18 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile but exhibit a slight delay in postnatal retinal angiogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020242 VEGA Gene Model | MGI Sequence Detail 24236 C57BL/6J ±  kb
    transcript OTTMUST00000048060 VEGA | MGI Sequence Detail 6591 Not Applicable  
    polypeptide OTTMUSP00000021932 VEGA | MGI Sequence Detail 1964 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      Genomic 7
      cDNA 81
      Primer pair 7
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11420, MGD-MRK-11427, MGD-MRK-36038
    References
    more
    • Summaries
      All 192
      Developmental Gene Expression 90
      Diseases 1
      Gene Ontology 10
      Phenotypes 34
    • Earliest
      J:7442 Dickson C, et al., Tumorigenesis by mouse mammary tumor virus: proviral activation of a cellular gene in the common integration region int-2. Cell. 1984 Jun;37(2):529-36
    • Latest
      J:257440 Dvoriantchikova G, et al., Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1098-1109

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory