About   Help   FAQ
Ccr5
Gene Detail
 Symbol
Name
ID
Ccr5
chemokine (C-C motif) receptor 5
MGI:107182
Synonyms CD195, Cmkbr5
Feature Type protein coding gene
Genetic Map
Chromosome 9
75.05 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:124121543-124147699 bp, + strand
From VEGA annotation of GRCm38

  26157 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr5

Human
homologs
Human Homolog CCR5, chemokine (C-C motif) receptor 5 (gene/pseudogene)
NCBI Gene ID 1234
neXtProt AC  NX_P51681
Human Synonyms  CCCKR5, CC-CKR-5, CCR-5, CD195, CKR5, CKR-5, CMKBR5, IDDM22
Human Chr (Location)  3p21.31; chr3:46370142-46376206 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human CCR5
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice that are homozygous for null alleles have leukocytes with defective migration and adhesion, are more susceptibility to fungal & bacterial infections, have increased length of allograft survival, and have decreased susceptibility to endotoxin shock.
 
Interactions
Ccr5 interacts with 201 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process calcium ion transport, calcium-mediated signaling, ...
Component cell surface, cytoplasm, ...
Function actin binding, C-C chemokine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (93)    Tissues (72)    Images (15)
Theiler Stages: 13, 19, 20, 23, 28
Assay TypeResults
RNA in situ 42
RT-PCR 46
RNase protection 5
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) Genomic(2) cDNA(51) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000035282 (Evidence)
Ensembl Gene ModelENSMUSG00000079227 (Evidence)
Entrez Gene12774 (Evidence)
UniGene14302
DFCITC1576052
DoTSDT.101160273, DT.99860465
NIA Mouse Gene IndexU011205
Consensus CDS ProjectCCDS40821.1
International Mouse Knockout Project StatusCcr5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035282 VEGA Gene Model | MGI Sequence Detail 26157 C57BL/6J ±  kb
transcript OTTMUST00000089983 VEGA | MGI Sequence Detail 2925 Not Applicable 
polypeptide OTTMUSP00000049245 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(377 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002240 CC chemokine receptor 5
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001201 C-C chemokine receptor type 5
References (Earliest) J:32263 Boring L, et al., Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9. J Biol Chem. 1996 Mar 29;271(13):7551-8
(Latest) J:206600 Mango RL, et al., C-C Chemokine Receptor 5 on Pulmonary Mesenchymal Cells Promotes Experimental Metastasis via the Induction of Erythroid Differentiation Regulator 1. Mol Cancer Res. 2014 Feb;12(2):274-82
All references(206)
Other
accession IDs
MGD-MRK-35643

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory