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Ccr5 Gene Detail
Summary
  • Symbol
    Ccr5
  • Name
    chemokine (C-C motif) receptor 5
  • Synonyms
    CD195, Cmkbr5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107182
    NCBI Gene: 12774
  • Gene Overview
    MyGene.info: CCR5
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:124121543-124127183 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 75.05 cM, cytoband F
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107182
protein coding gene Chr9:124121543-124147699 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035493
protein coding gene Chr9:127250058-127260327 (+)
A/J MGP_AJ_G0035471
protein coding gene Chr9:122336278-122362219 (+)
AKR/J MGP_AKRJ_G0035404
protein coding gene Chr9:125604074-125629422 (+)
BALB/cJ MGP_BALBcJ_G0035467
protein coding gene Chr9:122268068-122293931 (+)
C3H/HeJ MGP_C3HHeJ_G0035174
protein coding gene Chr9:126055978-126066228 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035990
protein coding gene Chr9:130695430-130722533 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032872
protein coding gene Chr9:119769490-119779943 (+)
CAST/EiJ MGP_CASTEiJ_G0034479
protein coding gene Chr9:126064624-126091404 (+)
CBA/J MGP_CBAJ_G0035142
protein coding gene Chr9:135513573-135523851 (+)
DBA/2J MGP_DBA2J_G0035301
protein coding gene Chr9:121827013-121837241 (+)
FVB/NJ MGP_FVBNJ_G0035248
protein coding gene Chr9:120670832-120681144 (+)
LP/J MGP_LPJ_G0035380
protein coding gene Chr9:127628062-127638341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035289
protein coding gene Chr9:136330493-136357217 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036009
protein coding gene Chr9:126097701-126124876 (+)
PWK/PhJ MGP_PWKPhJ_G0034183
protein coding gene Chr9:122224914-122235373 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034021
protein coding gene Chr9:126127141-126156895 (+)
WSB/EiJ MGP_WSBEiJ_G0034599
protein coding gene Chr9:125877739-125907963 (+)



Homology
more
  • Human Ortholog
    CCR5, C-C motif chemokine receptor 5 (gene/pseudogene)
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CCR5, C-C motif chemokine receptor 5 (gene/pseudogene)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CCCKR5, CC-CKR-5, CCR-5, CD195, CKR5, CKR-5, CMKBR5, IDDM22
  • Links
    NCBI Gene ID: 1234
    neXtProt AC: NX_P51681
    UniProt: P51681

  • Chr Location
    3p21.31; chr3:46370142-46376206 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CCR5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 4 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    2 images
    183 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice that are homozygous for null alleles have leukocytes with defective migration and adhesion, are more susceptibility to fungal & bacterial infections, have increased length of allograft survival, and have decreased susceptibility to endotoxin shock.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12774 NCBI Gene Model | MGI Sequence Detail 5641 C57BL/6J ±  kb
    transcript NM_009917 RefSeq | MGI Sequence Detail 2926 C57BL/6  
    polypeptide P51682 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 2
      cDNA 52
      Primer pair 1
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35643
    References
    more
    • Summaries
      All 245
      Developmental Gene Expression 4
      Gene Ontology 15
      Phenotypes 183
    • Earliest
      J:32263 Boring L, et al., Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9. J Biol Chem. 1996 Mar 29;271(13):7551-8
    • Latest
      J:265728 Lopes N, et al., Lymphotoxin alpha fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells. Nat Commun. 2018 Mar 28;9(1):1262

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory