Ccr5
Gene Detail

Symbol Name ID

Ccr5 chemokine (C-C motif) receptor 5 MGI:107182

Synonyms

CD195, Cmkbr5

Feature Type

protein coding gene

Genetic Map

Chromosome 9

75.05 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr9:124121543-124147699 bp, + strand From VEGA annotation of GRCm38   26157 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr5

Human homologs

Human Homolog		CCR5, chemokine (C-C motif) receptor 5 (gene/pseudogene)
NCBI Gene ID		1234
neXtProt AC		NX_P51681
Human Synonyms		CCCKR5, CC-CKR-5, CCR-5, CD195, CKR5, CKR-5, CMKBR5, IDDM22
Human Chr (Location)		3p21.31; chr3:46411633-46417697 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human CCR5

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice that are homozygous for null alleles have leukocytes with defective migration and adhesion, are more susceptibility to fungal & bacterial infections, have increased length of allograft survival, and have decreased susceptibility to endotoxin shock.

 

Gene Ontology (GO) classifications

All GO classifications: (59 annotations)

Process	calcium ion transport, calcium-mediated signaling, ...
Component	cell surface, cytoplasm, ...
Function	actin binding, C-C chemokine binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (93)    Tissues (72)    Images (15)
Theiler Stages: 13, 19, 20, 23, 28

Assay Type	Results
RNA in situ	42
RT-PCR	46
RNase protection	5

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(56) Genomic(2) cDNA(51) Primer pair(1) Other(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000035282 (Evidence)
Ensembl Gene Model	ENSMUSG00000079227 (Evidence)
Entrez Gene	12774 (Evidence)
UniGene	14302
DFCI	TC1576052
DoTS	DT.101160273, DT.99860465
NIA Mouse Gene Index	U011205
Consensus CDS Project	CCDS40821.1
International Mouse Knockout Project Status	Ccr5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035282	VEGA Gene Model | MGI Sequence Detail	26157	C57BL/6J
transcript	OTTMUST00000089983	VEGA | MGI Sequence Detail	2925	Not Applicable
polypeptide	OTTMUSP00000049245	VEGA | MGI Sequence Detail	354	Not Applicable

All sequences(47) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(101 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002240	CC chemokine receptor 5
InterPro	IPR000355	Chemokine receptor family
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001201	C-C chemokine receptor type 5

References

(Earliest) J:32263 Boring L, et al., Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9. J Biol Chem. 1996 Mar 29;271(13):7551-8
(Latest) J:195511 van Deventer HW, et al., Circulating Fibrocytes Prepare the Lung for Cancer Metastasis by Recruiting Ly-6C+ Monocytes Via CCL2. J Immunol. 2013 May 1;190(9):4861-7
All references(194)

Other accession IDs

MGD-MRK-35643