Phenotypes Associated with This Genotype

Genotype
MGI:4418655

• Allelic Composition: Ccr5^tm1Kuz/Ccr5^tm1Kuz
• Genetic Background: B6.129P2-Ccr5^tm1Kuz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

bronchiolitis ( J:162707 )

• mice infected with a recombinant mouse-adapted SARS-CoV, rMA15, develop more severe denuding bronchiolitis than similarly infected wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:84037 )

N • response to kainic acid similar to controls

N • become catatonic and display staring behavior within 15 minutes

N • myoclonic twitching, frequent rearing and falling

N • seizures lasting up to 5 hours

abnormal conditioned taste aversion behavior ( J:102583 )

• female mice develop a stronger ethanol-induced conditioned taste aversion compared with similarly treated wild-type mice

increased fluid intake ( J:102583 )

• of an ethanol, saccharin, or quinine solution

increased alcohol consumption ( J:102583 )

• in female but not male mice

immune system

bronchiolitis ( J:162707 )

• mice infected with a recombinant mouse-adapted SARS-CoV, rMA15, develop more severe denuding bronchiolitis than similarly infected wild-type mice

increased susceptibility to Coronaviridae infection ( J:162707 )

• mice show increased susceptibility to infection with a recombinant mouse-adapted SARS-CoV, rMA15 , developing more severe and prolonged disease compared to wild-type mice, showing more prominent airway epithelial cell apoptosis, severe denuding bronchiolitis and perivenular/periarterial cuffing

mortality/aging

mortality/aging ( J:84037 )

N • 40% mortality after kainic acid treatment

nervous system

nervous system phenotype ( J:84037 )

N • selective CA3 hippocampal pycnosis after kainic acid treatment as in controls

N • susceptibility of cerebral granule cell neurons to kainic acid is similar to controls

vision/eye

corneal vascularization ( J:118018 )

• 34% less neovascularization than controls 2 weeks after denudation of corneal epithelium

• 34.9% less neovascularization than controls 4 weeks after denudation of corneal epithelium

cardiovascular system

corneal vascularization ( J:118018 )

• 34% less neovascularization than controls 2 weeks after denudation of corneal epithelium

• 34.9% less neovascularization than controls 4 weeks after denudation of corneal epithelium

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Coronavirus infectious disease		DOID:0080599		J:162707