About   Help   FAQ
Targeted Allele Detail
Symbol: Ccr5tm1Kuz
Name: chemokine (C-C motif) receptor 5; targeted mutation 1, William A Kuziel
MGI ID: MGI:1861911
Synonyms: CCR5-, CCR5 KO, Cmkbr5tm1Kuz
Gene: Ccr5  Location: Chr9:123921557-123934153 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Alliance: Ccr5tm1Kuz page
Ccr5tm1Kuz/Ccr5tm1Kuz and wild-type littermates underwent bile duct ligation or sham operation. Macrophage infiltration was determined by immunohistochemistry for F4/80

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:64293
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe exon containing the entire coding region was replaced with a neomycin resistance gene inserted by homologous recombination. (J:84243)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ccr5 Mutation:  25 strains or lines available
Original:  J:64293 Huffnagle GB, et al., Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol. 1999 Nov 1;163(9):4642-6
All:  178 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory