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Ppp3r1 Gene Detail
Summary
  • Symbol
    Ppp3r1
  • Name
    protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
  • Synonyms
    CaNB1, Cnb1, PP2B beta 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107172
    NCBI Gene: 19058
  • Gene Overview
    MyGene.info: PPP3R1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:17159298-17200380 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 9.71 cM, cytoband A3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107172
protein coding gene Chr11:17159263-17200380 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018056
protein coding gene Chr11:14557313-14602189 (+)
A/J MGP_AJ_G0018029
protein coding gene Chr11:14059896-14101463 (+)
AKR/J MGP_AKRJ_G0017993
protein coding gene Chr11:14561533-14604145 (+)
BALB/cJ MGP_BALBcJ_G0017997
protein coding gene Chr11:14173891-14216322 (+)
C3H/HeJ MGP_C3HHeJ_G0017811
protein coding gene Chr11:14501260-14543898 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018449
protein coding gene Chr11:15182049-15232394 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016107
protein coding gene Chr11:13228866-13270494 (+)
CAST/EiJ MGP_CASTEiJ_G0017372
protein coding gene Chr11:14478210-14525106 (+)
CBA/J MGP_CBAJ_G0017785
protein coding gene Chr11:15988059-16031182 (+)
DBA/2J MGP_DBA2J_G0017895
protein coding gene Chr11:14043632-14083399 (+)
FVB/NJ MGP_FVBNJ_G0017887
protein coding gene Chr11:13841072-13885740 (+)
LP/J MGP_LPJ_G0017966
protein coding gene Chr11:14711921-14754389 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017913
protein coding gene Chr11:16430967-16474215 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018490
protein coding gene Chr11:14644776-14687280 (+)
PWK/PhJ MGP_PWKPhJ_G0017152
protein coding gene Chr11:14038790-14081080 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016949
protein coding gene Chr11:14407505-14452258 (+)
WSB/EiJ MGP_WSBEiJ_G0017426
protein coding gene Chr11:14345543-14388088 (+)



Homology
more
  • Human Ortholog
    PPP3R1, protein phosphatase 3 regulatory subunit B, alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP3R1, protein phosphatase 3 regulatory subunit B, alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CALNB1, CNB, CNB1
  • Links
    NCBI Gene ID: 5534
    neXtProt AC: NX_P63098
    UniProt: P63098

  • Chr Location
    2p14; chr2:68178857-68252519 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68099
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PPP3R1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ppp3r1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 4 alleles in 5 genetic backgrounds
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in embryonic death by midgestation due to vascular patterning defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19058 NCBI Gene Model | MGI Sequence Detail 41083 C57BL/6J ±  kb
    transcript NM_024459 RefSeq | MGI Sequence Detail 2829 C57BL/6  
    polypeptide Q63810 UniProt | EBI | MGI Sequence Detail 170 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      cDNA 130
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35633
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 14
      Phenotypes 60
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:265542 Wu X, et al., The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin. PLoS Genet. 2018 May;14(5):e1007366

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory