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Ppp3r1 Gene Detail
Summary
  • Symbol
    Ppp3r1
  • Name
    protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
  • Synonyms
    CaNB1, Cnb1, PP2B beta 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107172
    NCBI Gene: 19058
  • Gene Overview
    MyGene.info: PPP3R1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:17159263-17200375 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41113 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 9.71 cM, cytoband A3.1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PPP3R1, protein phosphatase 3 regulatory subunit B, alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP3R1, protein phosphatase 3 regulatory subunit B, alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CALNB1, CNB, CNB1
  • Links
    NCBI Gene ID: 5534
    neXtProt AC: NX_P63098
    UniProt: P63098

  • Chr Location
    2p14; chr2:68178857-68252519 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68099
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PPP3R1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ppp3r1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 4 alleles in 5 genetic backgrounds
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in embryonic death by midgestation due to vascular patterning defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005195 VEGA Gene Model | MGI Sequence Detail 41113 C57BL/6J ±  kb
    transcript OTTMUST00000011611 VEGA | MGI Sequence Detail 2859 Not Applicable  
    polypeptide OTTMUSP00000005397 VEGA | MGI Sequence Detail 170 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      219 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 129
      cDNA 128
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35633
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 11
      Phenotypes 56
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:260476 Weider M, et al., Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Nat Commun. 2018 Mar 2;9(1):899

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory