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Ppp3r1
Gene Detail
Symbol

Name
ID
Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
MGI:107172
Synonyms
CaNB1, Cnb1, PP2B beta 1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
9.71 cM, cytoband A3.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:17159263-17200375 bp, + strand
From VEGA annotation of GRCm38

  41113 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68099  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ppp3r1

Human
homologs
Human Homolog PPP3R1, protein phosphatase 3, regulatory subunit B, alpha
NCBI Gene ID 5534
neXtProt AC  NX_P63098
Human Synonyms  CALNB1, CNB, CNB1
Human Chr (Location)  2p15; chr2:68178857-68252519 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(6)
 
Homozygous inactivation of this gene results in embryonic death by midgestation due to vascular patterning defects.
 
Human Diseases Modeled Using Mouse Ppp3r1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ppp3r1 interacts with 358 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process epithelial to mesenchymal transition, heart development, ...
Component cell, cytoplasm, ...
Function calcium ion binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (2)    Tissues (2)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(128)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(129) cDNA(128) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005195 (Evidence)
Ensembl Gene ModelENSMUSG00000033953 (Evidence)
Entrez Gene19058 (Evidence)
UniGene41840
DFCITC1593143, TC1659508, TC1606700
DoTSDT.101363045, DT.97344694, DT.91333886, DT.55162242
Consensus CDS ProjectCCDS24448.1
International Mouse Knockout Project StatusPpp3r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005195 VEGA Gene Model | MGI Sequence Detail 41113 C57BL/6J ±  kb
transcript OTTMUST00000011611 VEGA | MGI Sequence Detail 2859 Not Applicable 
polypeptide OTTMUSP00000005397 VEGA | MGI Sequence Detail 170 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(221 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000013150 calcineurin subunit B type 1
References
(Earliest) J:2181 Ueki K, et al., Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B). Biochem Biophys Res Commun. 1992 Aug 31;187(1):537-43
(Latest) J:213158 Cho A, et al., Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. Neuron. 2014 Apr 2;82(1):109-24
All references(76)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-35633

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory