Phenotypes Associated with This Genotype

Genotype
MGI:3530740

• Allelic Composition: Ppp3r1^tm1Stl/Ppp3r1^tm1Stl; Tg(Camk2a-cre)CW2Stl/0
• Genetic Background: C57BL/6-Ppp3r1^tm1Stl Tg(Camk2a-cre)CW2Stl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84640 )

• appear normal and healthy, but prone to sudden death, with ~50% dead by 6 months of age

behavior/neurological

abnormal learning/memory/conditioning ( J:73203 )

• decreased working/episodic-like memory in delayed matching-to-place test, however memory extinction are normal

abnormal latent inhibition of conditioning behavior ( J:84640 )

• impaired latent inhibition in cued testing; however motor coordination, pain sensitivity, and cued fear conditioning are normal

abnormal spatial working memory ( J:73203 )

• reduced spatial working memory in radial maze test, however in a morris water maze test spatial reference memory appeared normal

hyperactivity ( J:84640 )

increased vertical activity ( J:84640 )

abnormal nest building behavior ( J:84640 )

• nests poorly formed

social withdrawal ( J:84640 )

nervous system

reduced sensorimotor gating ( J:84640 )

• significantly lower prepulse inhibition

reduced long-term depression ( J:73203 )

• seen in Schaffer collateral-CA1 synapse in hippocampal slices and at frequencies where LTD and LTP compete LTP is favored

growth/size/body

decreased body size ( J:84640 )

• 12% smaller than wild-type littermates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:73203 , J:84640