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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
MGI:107172
53 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Ppp3r1tm1.1Jhon/Ppp3r1tm1.1Jhon
involves: C57BL/6 * C57BL/6NTac
abnormal heart echocardiography feature J:298603
abnormal myocardial fiber morphology J:298603
cardiac interstitial fibrosis J:298603
congestive heart failure J:298603
decreased cardiac muscle contractility J:298603
dilated cardiomyopathy J:298603
increased cardiomyocyte apoptosis J:298603
increased heart left ventricle size J:298603
increased heart right ventricle size J:298603
premature death J:298603
thin ventricular wall J:298603
Ppp3r1tm1Grc/Ppp3r1tm1Grc
Not Specified
abnormal angiogenesis J:70266
abnormal blood vessel morphology J:70266
absent vitelline blood vessels J:70266
decreased embryo size J:70266
disorganized yolk sac vascular plexus J:70266
distended pericardium J:70266
embryonic lethality during organogenesis, complete penetrance J:70266
Ppp3r1tm1Stl/Ppp3r1tm1Stl
Tg(Camk2a-cre)CW2Stl/0
C57BL/6-Ppp3r1tm1Stl Tg(Camk2a-cre)CW2Stl
abnormal latent inhibition of conditioning behavior J:84640
abnormal learning/memory/conditioning J:73203
abnormal nest building behavior J:84640
abnormal spatial working memory J:73203
decreased body size J:84640
hyperactivity J:84640
increased vertical activity J:84640
premature death J:84640
reduced long-term depression J:73203
reduced sensorimotor gating J:84640
social withdrawal J:84640
Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Not Specified
abnormal angiogenesis J:89771
abnormal blood vessel morphology J:89771
abnormal extraembryonic tissue morphology J:89771
abnormal heart morphology J:89771
abnormal visceral yolk sac morphology J:89771
absent vitelline blood vessels J:89771
decreased embryo size J:89771
disorganized yolk sac vascular plexus J:89771
distended pericardium J:89771
embryonic lethality during organogenesis, complete penetrance J:89771
Ppp3r1tm2Grc/Ppp3r1tm2.1Grc
Tg(Lck-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
abnormal enzyme/coenzyme activity J:89771
abnormal lymph node cell ratio J:89771
abnormal positive T cell selection J:89771
abnormal splenic cell ratio J:89771
Ppp3r1tm2Grc/Ppp3r1tm2.1Grc
Tg(Pax3-cre)1Joe/0
involves: 129S6/SvEvTac
abnormal kidney pelvis morphology J:89217
abnormal ureter development J:89217
decreased cell proliferation J:89217
dilated kidney calyx J:89217
dilated renal tubule J:89217
hydronephrosis J:89217
impaired ureteric peristalsis J:89217
increased blood urea nitrogen level J:89217
kidney atrophy J:89217
kidney failure J:89217
renal interstitial fibrosis J:89217
ureteropelvic junction obstruction J:89217
Ppp3r1tm2Grc/Ppp3r1tm2Grc
Tg(GATA5-cre)1Krc/0
involves: 129S6/SvEvTac
normal cardiovascular system phenotype J:153636
Ppp3r1tm2Grc/Ppp3r1tm2Grc
Tg(Lck-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
decreased thymocyte number J:89771
thymus hypoplasia J:89771
Ppp3r1tm2Grc/Ppp3r1tm2Grc
Tg(Pax3-cre)1Joe/0
involves: 129S6/SvEvTac
abnormal kidney pelvis morphology J:89217
abnormal ureter development J:89217
decreased cell proliferation J:89217
dilated kidney calyx J:89217
dilated renal tubule J:89217
hydronephrosis J:89217
impaired ureteric peristalsis J:89217
increased blood urea nitrogen level J:89217
kidney atrophy J:89217
kidney failure J:89217
renal interstitial fibrosis J:89217
ureteropelvic junction obstruction J:89217
Ppp3r1tm2Grc/Ppp3r1tm2Grc
Tg(Tagln-cre)1Her/0
involves: 129S6/SvEvTac * C57BL/6 * SJL
normal cardiovascular system phenotype J:153636
Ppp3r1tm2Grc/Ppp3r1tm2Grc
Tg(Tek-cre)1Ywa/0
involves: 129S6/SvEvTac * C57BL/6 * SJL
abnormal heart development J:153636
abnormal vascular endothelial cell development J:153636
normal cardiovascular system phenotype J:153636
embryonic lethality during organogenesis, incomplete penetrance J:153636

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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory