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Adipoq Gene Detail
Summary
  • Symbol
    Adipoq
  • Name
    adiponectin, C1Q and collagen domain containing
  • Synonyms
    Acdc, Acrp30, Ad, adipo, adiponectin, apM1, APN, GBP28
  • Feature Type
    protein coding gene
  • IDs
    MGI:106675
    NCBI Gene: 11450
  • Gene Overview
    MyGene.info: ADIPOQ
Location & Maps
more
  • Sequence Map
    Chr16:23146536-23158028 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11493 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 13.96 cM, cytoband B3-B4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADIPOQ, adiponectin, C1Q and collagen domain containing
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADIPOQ, adiponectin, C1Q and collagen domain containing
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACDC, ACRP30, ADIPQTL1, ADPN, APM1, APM-1, GBP28
  • Links
    NCBI Gene ID: 9370
    neXtProt AC: NX_Q15848

  • Chr Location
    3q27; chr3:186842668-186858463 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    83 phenotypes from 6 alleles in 10 genetic backgrounds
    41 phenotypes from multigenic genotypes
    2 images
    153 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Targeted
    9
  • Transgenic
    1
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit increased beta-oxidation in muscle and liver, impaired free fatty acid clearance, and moderate insulin resistance. Heterozygotes show mild insulin resistance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035780 VEGA Gene Model | MGI Sequence Detail 11493 C57BL/6J ±  kb
transcript OTTMUST00000091562 VEGA | MGI Sequence Detail 1292 Not Applicable  
polypeptide OTTMUSP00000050447 VEGA | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    70 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 77
    Genomic 1
    cDNA 73
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35134
References
more
  • Summaries
    All 246
    Developmental Gene Expression 19
    Gene Ontology 26
    Phenotypes 153
  • Earliest
    J:32963 Scherer PE, et al., A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995 Nov 10;270(45):26746-9
  • Latest
    J:230250 Liu Y, et al., Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice. Diabetes. 2015 Jan;64(1):36-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory