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Adipoq
Gene Detail
Symbol

Name
ID
Adipoq
adiponectin, C1Q and collagen domain containing
MGI:106675
Synonyms
Acdc, Acrp30, adipo, adiponectin, apM1, APN, GBP28
Feature Type
protein coding gene
Genetic Map
Chromosome 16
13.96 cM, cytoband B3-B4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:23146536-23158028 bp, + strand
From VEGA annotation of GRCm38

  11493 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3525  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: complement subcomponent C1q chain A
Gene Tree: Adipoq

Human
homologs
Human Homolog ADIPOQ, adiponectin, C1Q and collagen domain containing
NCBI Gene ID 9370
neXtProt AC  NX_Q15848
Human Synonyms  ACDC, ACRP30, ADIPQTL1, ADPN, APM1, APM-1, GBP28
Human Chr (Location)  3q27; chr3:186842674-186858463 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit increased beta-oxidation in muscle and liver, impaired free fatty acid clearance, and moderate insulin resistance. Heterozygotes show mild insulin resistance.
 
Phenotype Images(2)
Interactions
Adipoq interacts with 57 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (98 annotations)
Process adiponectin-activated signaling pathway, brown fat cell differentiation, ...
Component cell surface, collagen trimer, ...
Function hormone activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (41)    Tissues (26)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
Northern blot 9
Western blot 2
RT-PCR 27
cDNA source data(71)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(76) Genomic(1) cDNA(73) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035780 (Evidence)
Ensembl Gene ModelENSMUSG00000022878 (Evidence)
Entrez Gene11450 (Evidence)
UniGene3969
DFCITC1578928
DoTSDT.536006
NIA Mouse Gene IndexU016957
PDB1C3H, 1C28
Consensus CDS ProjectCCDS28075.1
International Mouse Knockout Project StatusAdipoq
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035780 VEGA Gene Model | MGI Sequence Detail 11493 C57BL/6J ±  kb
transcript OTTMUST00000091562 VEGA | MGI Sequence Detail 1292 Not Applicable 
polypeptide OTTMUSP00000050447 VEGA | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR001073 Complement C1q protein
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000003777 adiponectin
References
(Earliest) J:32963 Scherer PE, et al., A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995 Nov 10;270(45):26746-9
(Latest) J:213228 Mori T, et al., Ultrastructural localization of adiponectin protein in vasculature of normal and atherosclerotic mice. Sci Rep. 2014;4:4895
All references(215)
Other
accession IDs
MGD-MRK-35134

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory