Adipoq
Gene Detail

Symbol Name ID

Adipoq adiponectin, C1Q and collagen domain containing MGI:106675

Synonyms

Acdc, Acrp30, adipo, adiponectin, apM1, APN, GBP28

Feature Type

protein coding gene

Genetic Map

Chromosome 16

13.96 cM, cytoband B3-B4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:23146536-23158028 bp, + strand From VEGA annotation of GRCm38   11493 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3525  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: complement subcomponent C1q chain A
Gene Tree: Adipoq

Human homologs

Human Homolog		ADIPOQ, adiponectin, C1Q and collagen domain containing
NCBI Gene ID		9370
neXtProt AC		NX_Q15848
Human Synonyms		ACDC, ACRP30, ADIPQTL1, ADPN, APM1, APM-1, GBP28
Human Chr (Location)		3q27; chr3:186560463-186576252 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Homozygotes for targeted null mutations exhibit increased beta-oxidation in muscle and liver, impaired free fatty acid clearance, and moderate insulin resistance. Heterozygotes show mild insulin resistance.

 

Gene Ontology (GO) classifications

All GO classifications: (92 annotations)

Process	adiponectin-mediated signaling pathway, brown fat cell differentiation, ...
Component	collagen, endoplasmic reticulum, ...
Function	hormone activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (41)    Tissues (26)    Images (6)
Theiler Stages: 10, 18, 21, 23, 25, 28

Assay Type	Results
RNA in situ	3
Northern blot	9
Western blot	2
RT-PCR	27

cDNA source data(70)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(75) Genomic(1) cDNA(72) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035780 (Evidence)
Ensembl Gene Model	ENSMUSG00000022878 (Evidence)
Entrez Gene	11450 (Evidence)
UniGene	3969
DFCI	TC1578928
DoTS	DT.536006
NIA Mouse Gene Index	U016957
PDB	1C3H, 1C28
Consensus CDS Project	CCDS28075.1
International Mouse Knockout Project Status	Adipoq

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035780	VEGA Gene Model | MGI Sequence Detail	11493	C57BL/6J
transcript	OTTMUST00000091562	VEGA | MGI Sequence Detail	1292	Not Applicable
polypeptide	OTTMUSP00000050447	VEGA | MGI Sequence Detail	247	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(56 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008160	Collagen triple helix repeat
InterPro	IPR001073	Complement C1q protein
InterPro	IPR008983	Tumour necrosis factor-like domain
Protein Ontology	PR:000003777	adiponectin

References

(Earliest) J:32963 Scherer PE, et al., A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995 Nov 10;270(45):26746-9
(Latest) J:195521 Han S, et al., Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells. J Immunol. 2013 May 1;190(9):4877-86
All references(186)

Other accession IDs

MGD-MRK-35134