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Adipoq Gene Detail
Summary
  • Symbol
    Adipoq
  • Name
    adiponectin, C1Q and collagen domain containing
  • Synonyms
    Acdc, Acrp30, Ad, adipo, adiponectin, apM1, APN, GBP28
  • Feature Type
    protein coding gene
  • IDs
    MGI:106675
    NCBI Gene: 11450
  • Gene Overview
    MyGene.info: ADIPOQ
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:23146536-23158028 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11493 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 13.96 cM, cytoband B3-B4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADIPOQ, adiponectin, C1Q and collagen domain containing
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADIPOQ, adiponectin, C1Q and collagen domain containing
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACDC, ACRP30, ADIPQTL1, ADPN, APM1, APM-1, GBP28
  • Links
    NCBI Gene ID: 9370
    neXtProt AC: NX_Q15848
    UniProt: Q15848

  • Chr Location
    3q27.3; chr3:186842674-186858463 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    87 phenotypes from 6 alleles in 11 genetic backgrounds
    41 phenotypes from multigenic genotypes
    2 images
    172 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit increased beta-oxidation in muscle and liver, impaired free fatty acid clearance, and moderate insulin resistance. Heterozygotes show mild insulin resistance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035780 VEGA Gene Model | MGI Sequence Detail 11493 C57BL/6J ±  kb
    transcript OTTMUST00000091562 VEGA | MGI Sequence Detail 1292 Not Applicable  
    polypeptide OTTMUSP00000050447 VEGA | MGI Sequence Detail 247 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      70 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      Genomic 1
      cDNA 74
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35134
    References
    more
    • Summaries
      All 331
      Developmental Gene Expression 25
      Gene Ontology 32
      Phenotypes 172
    • Earliest
      J:32963 Scherer PE, et al., A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995 Nov 10;270(45):26746-9
    • Latest
      J:262992 Zhuang L, et al., Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun. 2018 May 4;9(1):1796

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory