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Cdh15
Gene Detail
Symbol

Name
ID
Cdh15
cadherin 15
MGI:106672
Synonyms
Cdh14, Mcad, M cadherin
Feature Type
protein coding gene
Genetic Map
Chromosome 8
71.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:122848374-122867397 bp, + strand
From NCBI annotation of GRCm38

  19024 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3622  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cadherin
Gene Tree: Cdh15

Human
homologs
Human Homolog CDH15, cadherin 15, type 1, M-cadherin (myotubule)
NCBI Gene ID 1013
neXtProt AC  NX_P55291
Human Synonyms  CDH14, CDH3, CDHM, MCAD, MRD3
Human Chr (Location)  16q24.3; chr16:89171755-89195492 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CDH15
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable, fertile, and show no apparent defects in the development, maintenance, or regeneration of skeletal muscle or in the cerebellum.
 
Interactions
Cdh15 interacts with 53 markers (Mir22, Mir30b, Mir31, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules
Component caveola, extracellular vesicular exosome, ...
Function calcium ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (198)    Tissues (170)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 170
Western blot 3
RT-PCR 10
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(19) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031962 (Evidence)
Entrez Gene12555 (Evidence)
UniGene1976
DFCITC1581924
DoTSDT.488581
NIA Mouse Gene IndexU009919
Consensus CDS ProjectCCDS22746.1
International Mouse Knockout Project StatusCdh15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12555 NCBI Gene Model | MGI Sequence Detail 19024 C57BL/6J ±  kb
transcript NM_007662 RefSeq | MGI Sequence Detail 2843 Not Specified 
polypeptide P33146 UniProt | EBI | MGI Sequence Detail 784 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(216 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000005233 cadherin-15
Graphical View of Protein Domain Structure
References
(Earliest) J:11403 Hatta M, et al., Genomic organization and chromosomal mapping of the mouse P-cadherin gene. Nucleic Acids Res. 1991 Aug 25;19(16):4437-41
(Latest) J:200444 Millay DP, et al., Myomaker is a membrane activator of myoblast fusion and muscle formation. Nature. 2013 Jul 18;499(7458):301-5
All references(55)
Other
accession IDs
MGD-MRK-16328, MGD-MRK-19362, MGD-MRK-35131, MGI:2142505, MGI:99550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory