Cdh15
Gene Detail

Symbol Name ID

Cdh15 cadherin 15 MGI:106672

Synonyms

Cdh14, Mcad, M cadherin

Feature Type

protein coding gene

Genetic Map

Chromosome 8

71.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr8:122848374-122867397 bp, + strand From NCBI annotation of GRCm38   19024 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3622  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: cadherin
Gene Tree: Cdh15

Human homologs

Human Homolog		CDH15, cadherin 15, type 1, M-cadherin (myotubule)
NCBI Gene ID		1013
neXtProt AC		NX_P55291
Human Synonyms		CDH14, CDH3, CDHM, MCAD, MRD3
Human Chr (Location)		16q24.3; chr16:89238163-89261900 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CDH15

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous null mice are viable, fertile, and show no apparent defects in the development, maintenance, or regeneration of skeletal muscle or in the cerebellum.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell adhesion, homophilic cell adhesion
Component	caveola, integral to membrane, ...
Function	calcium ion binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (197)    Tissues (168)    Images (40)
Theiler Stages: 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	170
Western blot	3
RT-PCR	10

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(19) Primer pair(2) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031962 (Evidence)
Entrez Gene	12555 (Evidence)
UniGene	1976
DFCI	TC1581924
DoTS	DT.488581
NIA Mouse Gene Index	U009919
Consensus CDS Project	CCDS22746.1
International Mouse Knockout Project Status	Cdh15

Sequences

Length	Strain/Species
genomic	12555	NCBI Gene Model | MGI Sequence Detail	19024	C57BL/6J
transcript	NM_007662	RefSeq | MGI Sequence Detail	2843	Not Specified
polypeptide	P33146	UniProt | EBI | MGI Sequence Detail	784	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(123 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002126	Cadherin
InterPro	IPR020894	Cadherin conserved site
InterPro	IPR000233	Cadherin, cytoplasmic domain
InterPro	IPR015919	Cadherin-like
Protein Ontology	PR:000005233	cadherin-15

Graphical View of Protein Domain Structure

References

(Earliest) J:11403 Hatta M, et al., Genomic organization and chromosomal mapping of the mouse P-cadherin gene. Nucleic Acids Res. 1991 Aug 25;19(16):4437-41
(Latest) J:188916 Brohl D, et al., Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals. Dev Cell. 2012 Sep 11;23(3):469-81
All references(51)

Other accession IDs

MGD-MRK-16328, MGD-MRK-19362, MGD-MRK-35131, MGI:2142505, MGI:99550