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Rfx3
Gene Detail
Symbol

Name
ID
Rfx3
regulatory factor X, 3 (influences HLA class II expression)
MGI:106582
Synonyms
C230093O12Rik, MRFX3
Feature Type
protein coding gene
Genetic Map
Chromosome 19
22.36 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:27766441-28011166 bp, - strand
From VEGA annotation of GRCm38

  244726 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7917  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RFX3
Protein SuperFamily: DNA binding protein RFX2
Gene Tree: Rfx3

Human
homologs
RFX3, regulatory factor X, 3 (influences HLA class II expression)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5991
neXtProt AC: NX_P48380

Human Chr (Location): 9p24.2; chr9:3218297-3526001 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(50) : Chemically induced (ENU)(1) Gene trapped(43) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display embryonic and perinatal lethality, impaired development of cilia on the embryonic node, abnormal left-right patterning, meso- and dextrocardia, and situs inversus in surviving adults.
 
Phenotype Images(4)
Interactions
Rfx3 interacts with 537 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell differentiation, cell maturation, ...
Component nuclear chromatin, nucleus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (81)    Tissues (59)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 73
RT-PCR 8
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rfx3    NEW 
Molecular
reagents
All nucleic(44) cDNA(43) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000037650 (Evidence)
Ensembl Gene Model ENSMUSG00000040929 (Evidence)
Entrez Gene 19726 (Evidence)
UniGene 313321
DFCI TC1589359, TC1591700, TC1592830, TC1608632
DoTS DT.101217222, DT.101221335, DT.101296278, DT.40163911, DT.91411301, DT.91423355, DT.91551276
NIA Mouse Gene Index U038946, U038947, U199160
Consensus CDS Project CCDS29725.1
International Mouse Phenotyping Consortium Status Rfx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037650 VEGA Gene Model | MGI Sequence Detail 244726 C57BL/6J ±  kb
transcript OTTMUST00000097173 VEGA | MGI Sequence Detail 2743 Not Applicable 
polypeptide OTTMUSP00000054439 VEGA | MGI Sequence Detail 749 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(25) UniProt(5)
Polymorphisms
SNPs within 2kb(955 from dbSNP Build 137)    SNPs within 2kb including multiple locations(959)
Protein-related
information
ResourceIDDescription
InterPro IPR003150 DNA-binding RFX-type winged-helix domain
InterPro IPR007668 RFX1 transcription activation region
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013925 transcription factor RFX3
References
(Earliest) J:32459 Reith W, et al., RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol Cell Biol. 1994 Feb;14(2):1230-44
(Latest) J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4
All references(59)
Other
accession IDs
MGD-MRK-35038, MGI:2444250

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory