About   Help   FAQ
Rfx3 Gene Detail
Summary
  • Symbol
    Rfx3
  • Name
    regulatory factor X, 3 (influences HLA class II expression)
  • Synonyms
    C230093O12Rik, MRFX3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106582
    NCBI Gene: 19726
  • Gene Overview
    MyGene.info: RFX3
Location & Maps
more
  • Sequence Map
    Chr19:27766441-28011166 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      244726 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RFX3, regulatory factor X3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RFX3, regulatory factor X3
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 5991
    neXtProt AC: NX_P48380

  • Chr Location
    9p24.2; chr9:3218297-3526001 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 5 alleles in 2 genetic backgrounds
    4 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    50
  • Chemically induced (ENU)
    1
  • Gene trapped
    43
  • Targeted
    6
  • Incidental Mutations
Homozygous null mice display embryonic and perinatal lethality, impaired development of cilia on the embryonic node, abnormal left-right patterning, meso- and dextrocardia, and situs inversus in surviving adults.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037650 VEGA Gene Model | MGI Sequence Detail 244726 C57BL/6J ±  kb
transcript OTTMUST00000097173 VEGA | MGI Sequence Detail 2743 Not Applicable  
polypeptide OTTMUSP00000054439 VEGA | MGI Sequence Detail 749 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    948 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013925 transcription factor RFX3
  • InterPro Domains
    IPR003150 DNA-binding RFX-type winged-helix domain
    IPR007668 RFX1 transcription activation region
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 44
    cDNA 43
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-35038, MGI:2444250
References
more
  • Summaries
    All 59
    Developmental Gene Expression 24
    Gene Ontology 10
    Phenotypes 16
  • Earliest
    J:32459 Reith W, et al., RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol Cell Biol. 1994 Feb;14(2):1230-44
  • Latest
    J:225435 Laclef C, et al., The role of primary cilia in corpus callosum formation is mediated by production of the Gli3 repressor. Hum Mol Genet. 2015 Sep 1;24(17):4997-5014

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory