Rfx3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rfx3
regulatory factor X, 3 (influences HLA class II expression)
MGI:106582

16 phenotypes from 5 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gfi1^tm1(cre)Gan/Gfi1⁺ Rfx3^tm2Wrth/Rfx3^tm2Wrth involves: 129 * 129S7/SvEvBrd	normal hearing/vestibular/ear phenotype	J:227631
Rfx3^b2b1213Clo/Rfx3^b2b1213Clo C57BL/6J-Rfx3^b2b1213Clo	cardiomyopathy	J:175213
	heterotaxia	J:175213
	ventricular septal defect	J:175213
Rfx3^tm1.1Wrth/Rfx3⁺ involves: 129 * C57BL/6J	postnatal growth retardation	J:89880
Rfx3^tm1.1Wrth/Rfx3^tm1.1Wrth involves: 129 * C57BL/6J	abnormal direction of embryo turning	J:89880
	abnormal direction of heart looping	J:89880
	abnormal left-right axis patterning	J:89880
	abnormal motile primary cilium morphology	J:89880
	decreased birth body size	J:89880
	dextrocardia	J:89880
	embryonic lethality during organogenesis, incomplete penetrance	J:89880
	mesocardia	J:89880
	perinatal lethality, incomplete penetrance	J:89880
	postnatal growth retardation	J:89880
	situs inversus	J:89880
Rfx3^tm1Wrth/Rfx3^tm1Wrth involves: 129 * C57BL/6J	no abnormal phenotype detected	J:89880
Rfx3^tm2.1Wrth/Rfx3⁺ involves: 129 * C57BL/6J	postnatal growth retardation	J:89880
Rfx3^tm2.1Wrth/Rfx3^tm2.1Wrth involves: 129 * C57BL/6J	abnormal direction of embryo turning	J:89880
	abnormal direction of heart looping	J:89880
	abnormal left-right axis patterning	J:89880
	abnormal motile primary cilium morphology	J:89880
	decreased birth body size	J:89880
	dextrocardia	J:89880
	embryonic lethality during organogenesis, incomplete penetrance	J:89880
	mesocardia	J:89880
	perinatal lethality, incomplete penetrance	J:89880
	postnatal growth retardation	J:89880
	situs inversus	J:89880
Rfx3^tm2Wrth/Rfx3^tm2Wrth involves: 129 * C57BL/6J	no abnormal phenotype detected	J:89880

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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