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Slx4
Gene Detail
 Symbol
Name
ID
Slx4
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
MGI:106299
Synonyms Btbd12, D16Bwg1016e
Feature Type protein coding gene
Genetic Map
Chromosome 16
2.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:3979105-4003770 bp, - strand
From VEGA annotation of GRCm38

  24666 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23770  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Slx4

Human
homologs
Human Homolog SLX4, SLX4 structure-specific endonuclease subunit
NCBI Gene ID 84464
neXtProt AC  NX_Q8IY92
Human Synonyms  BTBD12, FANCP, MUS312
Human Chr (Location)  16p13.3; chr16:3581181-3611584 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLX4
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit some preweaning lethality, reduced fertility, abnormal eye morphology, abnormal skeletal morphology, hydrocephalus, chromosomal instability, early cellular replicative senescence, and abnormal lymphopoeisis.
 
Interactions
Slx4 interacts with 355 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cellular response to DNA damage stimulus, DNA catabolic process, endonucleolytic, ...
Component cell junction, cytoplasm, ...
Function 3'-flap endonuclease activity, 5'-flap endonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(47)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017267 (Evidence)
Ensembl Gene ModelENSMUSG00000039738 (Evidence)
Entrez Gene52864 (Evidence)
UniGene29935
DFCITC1580603, TC1595720, TC1603037
DoTSDT.101228026, DT.103585870, DT.40168469, DT.87058423, DT.94180801
NIA Mouse Gene IndexU036727
Consensus CDS ProjectCCDS37240.1
International Mouse Knockout Project StatusSlx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017267 VEGA Gene Model | MGI Sequence Detail 24666 C57BL/6J ±  kb
transcript OTTMUST00000041796 VEGA | MGI Sequence Detail 5706 Not Applicable 
polypeptide OTTMUSP00000018794 VEGA | MGI Sequence Detail 1565 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(24) UniProt(10)
Polymorphisms SNPs within 2kb(189 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR018574 Structure-specific endonuclease subunit SLX4
Protein Ontology PR:000032289 structure-specific endonuclease subunit SLX4
References (Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:204996 Castor D, et al., Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases. Mol Cell. 2013 Oct 24;52(2):221-33
All references(38)
Other
accession IDs
MGD-MRK-33991, MGI:2146396, MGI:2146426

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory