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Slx4 Gene Detail
Summary
  • Symbol
    Slx4
  • Name
    SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
  • Synonyms
    Btbd12, D16Bwg1016e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106299
    NCBI Gene: 52864
  • Gene Overview
    MyGene.info: SLX4
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:3979105-4003770 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 2.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106299
protein coding gene Chr16:3979105-4003829 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022458
protein coding gene Chr16:430539-457870 (-)
A/J MGP_AJ_G0022419
protein coding gene Chr16:304583-329782 (-)
AKR/J MGP_AKRJ_G0022396
protein coding gene Chr16:445897-470496 (-)
BALB/cJ MGP_BALBcJ_G0022424
protein coding gene Chr16:427530-452436 (-)
C3H/HeJ MGP_C3HHeJ_G0022191
protein coding gene Chr16:477572-503713 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022873
protein coding gene Chr16:471336-500300 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020395
protein coding gene Chr16:254812-281226 (-)
CAST/EiJ MGP_CASTEiJ_G0021718
protein coding gene Chr16:435779-460692 (-)
CBA/J MGP_CBAJ_G0022160
protein coding gene Chr16:540936-569571 (-)
DBA/2J MGP_DBA2J_G0022291
protein coding gene Chr16:412048-436888 (-)
FVB/NJ MGP_FVBNJ_G0022267
protein coding gene Chr16:380081-405165 (-)
LP/J MGP_LPJ_G0022360
protein coding gene Chr16:436632-464008 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022289
protein coding gene Chr16:426665-451529 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022885
protein coding gene Chr16:410295-434825 (-)
PWK/PhJ MGP_PWKPhJ_G0021458
protein coding gene Chr16:447246-473192 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021290
protein coding gene Chr16:519615-545361 (-)
WSB/EiJ MGP_WSBEiJ_G0021767
protein coding gene Chr16:443423-471083 (-)



Homology
more
  • Human Ortholog
    SLX4, SLX4 structure-specific endonuclease subunit
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLX4, SLX4 structure-specific endonuclease subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTBD12, FANCP, MUS312
  • Links
    NCBI Gene ID: 84464
    neXtProt AC: NX_Q8IY92
    UniProt: Q8IY92

  • Chr Location
    16p13.3; chr16:3581181-3611598 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Slx4 mouse models; 1 with human SLX4 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    61 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit some preweaning lethality, reduced fertility, abnormal eye morphology, abnormal skeletal morphology, hydrocephalus, chromosomal instability, early cellular replicative senescence, and abnormal lymphopoeisis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039738 Ensembl Gene Model | MGI Sequence Detail 24666 C57BL/6J ±  kb
transcript ENSMUST00000040790 Ensembl | MGI Sequence Detail 5706 Not Applicable  
polypeptide ENSMUSP00000038871 Ensembl | MGI Sequence Detail 1565 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    cDNA 48
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33991, MGI:2146396, MGI:2146426
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:240753 Alavattam KG, et al., Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications. Cell Rep. 2016 Oct 18;17(4):1141-1157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory