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Slx4 Gene Detail
Summary
  • Symbol
    Slx4
  • Name
    SLX4 structure-specific endonuclease subunit
  • Synonyms
    Btbd12, D16Bwg1016e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106299
    NCBI Gene: 52864
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:3796969-3821634 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    597 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106299
 protein coding gene Chr16:3796969-3821708 (-)
129S1/SvImJ ENSMUSG00200009926
 protein coding gene Chr16:788351-810908 (-)
A/J ENSMUSG00195010669
 protein coding gene Chr16:340513-363078 (-)
AKR/J ENSMUSG00220016953
 protein coding gene Chr16:639687-662244 (-)
BALB/cJ ENSMUSG00180007663
 protein coding gene Chr16:589265-611822 (-)
C3H/HeJ ENSMUSG00175027693
 protein coding gene Chr16:780579-803137 (-)
C57BL/6NJ ENSMUSG00215019071
 protein coding gene Chr16:461811-484370 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020395
 protein coding gene Chr16:254812-281226 (-)
CAST/EiJ ENSTCUG00005031110
 protein coding gene Chr16:664328-686932 (-)
CBA/J ENSMUSG00210011694
 protein coding gene Chr16:797903-820464 (-)
DBA/2J ENSMUSG00185009158
 protein coding gene Chr16:743105-765662 (-)
FVB/NJ ENSMUSG00205010227
 protein coding gene Chr16:664387-686956 (-)
JF1/MsJ ENSUMUG00000033758
 protein coding gene Chr16:758048-780620 (-)
LP/J ENSMUSG00230010961
 protein coding gene Chr16:3284131-3306688 (-)
NOD/ShiLtJ ENSMUSG00190022171
 protein coding gene Chr16:818518-841075 (-)
NZO/HlLtJ ENSMUSG00225022787
 protein coding gene Chr16:6526480-6549037 (-)
PWK/PhJ ENSLUMG00010017734
 protein coding gene Chr16:636427-658980 (-)
SPRET/EiJ ENSMSPG00010017182
 protein coding gene Chr16:604833-626688 (-)
WSB/EiJ ENSIUOG00005015792
 protein coding gene Chr16:782926-805495 (-)



Homology
more
  • Human Ortholog
    SLX4, SLX4 structure-specific endonuclease subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLX4, SLX4 structure-specific endonuclease subunit
  • Synonyms
    BTBD12, FANCP, MUS312
  • Links
    NCBI Gene ID: 84464
    UniProt: Q8IY92

  • Chr Location
    16p13.3; chr16:3581181-3611606 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slx4 mouse models; 1 with human SLX4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    61 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit some preweaning lethality, reduced fertility, abnormal eye morphology, abnormal skeletal morphology, hydrocephalus, chromosomal instability, early cellular replicative senescence, and abnormal lymphopoeisis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    48
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039738 Ensembl Gene Model | MGI Sequence Detail 24666 C57BL/6J ±  kb
    transcript ENSMUST00000040790 Ensembl | MGI Sequence Detail 5706 Not Applicable  
    polypeptide ENSMUSP00000038871 Ensembl | MGI Sequence Detail 1565 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 48
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33991, MGI:2146396, MGI:2146426
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory