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Slx4
Gene Detail
Symbol

Name
ID
Slx4
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
MGI:106299
Synonyms
Btbd12, D16Bwg1016e
Feature Type
protein coding gene
Genetic Map
Chromosome 16
2.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:3979105-4003770 bp, - strand
From VEGA annotation of GRCm38

  24666 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23770  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: SLX4
Gene Tree: Slx4

Human
homologs
SLX4, SLX4 structure-specific endonuclease subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 84464
neXtProt AC: NX_Q8IY92

Human Synonyms: BTBD12, FANCP, MUS312

Human Chr (Location): 16p13.3; chr16:3581165-3611598 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SLX4

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit some preweaning lethality, reduced fertility, abnormal eye morphology, abnormal skeletal morphology, hydrocephalus, chromosomal instability, early cellular replicative senescence, and abnormal lymphopoeisis.
 
Interactions
Slx4 interacts with 354 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
cDNA source data(47)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slx4    NEW 
Molecular
reagents
All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017267 (Evidence)
Ensembl Gene Model ENSMUSG00000039738 (Evidence)
Entrez Gene 52864 (Evidence)
UniGene 29935
DFCI TC1603037, TC1595720, TC1580603
DoTS DT.40168469, DT.103585870, DT.101228026, DT.87058423, DT.94180801
NIA Mouse Gene Index U036727
Consensus CDS Project CCDS37240.1
International Mouse Phenotyping Consortium Status Slx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017267 VEGA Gene Model | MGI Sequence Detail 24666 C57BL/6J ±  kb
transcript OTTMUST00000041796 VEGA | MGI Sequence Detail 5706 Not Applicable 
polypeptide OTTMUSP00000018794 VEGA | MGI Sequence Detail 1565 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(23) UniProt(10)
Polymorphisms
SNPs within 2kb(189 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR018574 Structure-specific endonuclease subunit SLX4
Protein Ontology PR:000032289 structure-specific endonuclease subunit SLX4
References
(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:214661 Lachaud C, et al., Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia. J Cell Sci. 2014 Jul 1;127(Pt 13):2811-7
All references(40)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-33991, MGI:2146396, MGI:2146426

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory