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Symbol
Name
ID

Slx4
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
MGI:106299

Phenotype annotations related to cellular

Darker colors indicate more annotations

Human Phenotypes	Chromosomal breakage induced by crosslinking agents
Disease(s) Associated with SLX4	Chromosomal breakage induced by crosslinking agents
Fanconi anemia complementation group P

Mouse Phenotypes

absent oocytes

azoospermia

oligozoospermia

abnormal primordial germ cell morphology

abnormal telomere morphology

increased sensitivity to induced cell death

abnormal male germ cell apoptosis

early cellular replicative senescence

abnormal DNA repair

chromosomal instability

induced chromosome breakage

Availability

Mouse Genotype

Slx4^tm1.2Jrou/Slx4^tm1.2Jrou

Slx4^{tm1a(EUCOMM)Wtsi}/Slx4^{tm1a(EUCOMM)Wtsi}

Slx4^tm1Jrou/Slx4^tm1Jrou

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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