About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slx4
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
MGI:106299
61 phenotypes from 4 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Slx4m1Btlr/Slx4m1Btlr
C57BL/6J-Slx4m1Btlr 		decreased body weight J:236683
Slx4tm1.2Jrou/Slx4tm1.2Jrou
B6.129P2-Slx4tm1.2Jrou 		abnormal DNA repair J:204996
embryonic lethality, incomplete penetrance J:204996
increased sensitivity to induced cell death J:204996
induced chromosome breakage J:204996
preweaning lethality, incomplete penetrance J:204996
small testis J:204996
Slx4tm1.2Jrou/Slx4tm1.2Jrou
involves: 129P2/OlaHsd * C57BL/6 		preweaning lethality, complete penetrance J:204996
Slx4tm1a(EUCOMM)Wtsi/Slx4+
B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi 		increased bone mineral density J:165965
Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi 		abnormal cornea morphology J:165965
abnormal cranium morphology J:175295
abnormal eye morphology J:165965
abnormal eye size J:165965, J:175295
abnormal placement of pupils J:165965
anophthalmia J:175295
corneal opacity J:165965
decreased body weight J:165965
thrombocytopenia J:165965
Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
C57BL/6N-Slx4tm1a(EUCOMM)Wtsi 		abnormal cerebral cortex morphology J:168567
abnormal cornea morphology J:168567
abnormal cranium morphology J:168567
abnormal eye morphology J:168567
abnormal eyelid aperture J:168567
abnormal iris morphology J:168567
abnormal lymphopoiesis J:168567
abnormal male germ cell apoptosis J:168567
abnormal primordial germ cell morphology J:168567
abnormal pupil morphology J:168567
abnormal retina vasculature morphology J:168567
abnormal spermatogenesis J:168567
abnormal spine curvature J:168567
abnormal third ventricle morphology J:168567
abnormal tooth morphology J:168567
absent corpus luteum J:168567
absent mature ovarian follicles J:168567
absent oocytes J:168567
absent optic nerve J:168567
anophthalmia J:168567
azoospermia J:168567
chromosomal instability J:168567
corneal opacity J:168567
decreased body size J:168567
decreased body weight J:168567
decreased common myeloid progenitor cell number J:168567
decreased leukocyte cell number J:168567
decreased litter size J:168567
dilated lateral ventricle J:168567
domed cranium J:168567
early cellular replicative senescence J:168567
enlarged cranium J:168567
hydrocephaly J:168567
impaired glucose tolerance J:168567
increased caudal vertebrae number J:168567
increased circulating glucose level J:168567
increased erythrocyte cell number J:168567
increased physiological sensitivity to xenobiotic J:188123
increased sensitivity to induced cell death J:188123
lethality throughout fetal growth and development, incomplete penetrance J:168567
microphthalmia J:168567
normal nervous system phenotype J:168567
obstructive hydrocephaly J:168567
oligozoospermia J:168567
perinatal lethality, incomplete penetrance J:168567
postnatal growth retardation J:168567
reduced female fertility J:168567
reduced male fertility J:168567
thin cerebral cortex J:168567
thrombocytopenia J:168567
vertebral fusion J:168567
Slx4tm1Jrou/Slx4tm1Jrou
Not Specified 		abnormal telomere morphology J:202845
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory