Phenotypes Associated with This Genotype

Genotype
MGI:5559492

• Allelic Composition: Slx4^tm1.2Jrou/Slx4^tm1.2Jrou
• Genetic Background: B6.129P2-Slx4^tm1.2Jrou

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:204996 )

• fewer than expected mice are obtained at E13.5

preweaning lethality, incomplete penetrance ( J:204996 )

• fewer than expected mice are obtained at weaning

reproductive system

small testis ( J:204996 )

• at 10 weeks

cellular

increased sensitivity to induced cell death ( J:204996 )

• in mouse embryonic fibroblasts treated with DNA interstrand crosslinking agents (nitrogen mustard and MMC)

abnormal DNA repair ( J:204996 )

induced chromosome breakage ( J:204996 )

• chromatid breaks and radial structures in MMC-treated mouse embryonic fibroblasts

endocrine/exocrine glands

small testis ( J:204996 )

• at 10 weeks

homeostasis/metabolism

abnormal DNA repair ( J:204996 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Fanconi anemia complementation group P	DOID:0111092	OMIM:613951	J:204996
Fanconi-like syndrome		DOID:0090066	OMIM:227850	J:204996