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Gpx3 Gene Detail
Summary
  • Symbol
    Gpx3
  • Name
    glutathione peroxidase 3
  • Synonyms
    EGPx, extracellular GPx, GPx, plasma GPx
  • Feature Type
    protein coding gene
  • IDs
    MGI:105102
    NCBI Gene: 14778
Location & Maps
more
  • Sequence Map
    Chr11:54902453-54910377 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7925 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GPX3, glutathione peroxidase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPX3, glutathione peroxidase 3
    Orthology source: HomoloGene
  • Synonyms
    GPx-P, GSHPx-3, GSHPx-P
  • Links
    NCBI Gene ID: 2878
    neXtProt AC: NX_P22352

  • Chr Location
    5q33.1; chr5:151020438-151028993 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Targeted
    8
  • Transgenic
    1
  • Genomic Mutations
    2 involving Gpx3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced glutathione peroxidase activity, increase plasma selenium levels when mice are fed a selenium supplemented diet, and reduced kidney selenium levels regardless of selenium supplementation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006337 VEGA Gene Model | MGI Sequence Detail 7925 C57BL/6J ±  kb
transcript OTTMUST00000014399 VEGA | MGI Sequence Detail 1594 Not Applicable  
polypeptide OTTMUSP00000006678 VEGA | MGI Sequence Detail 226 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    69 from dbSNP Build 137
Protein
Information
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Molecular
Reagents
less
  • All nucleic 1584
    Genomic 1
    cDNA 1580
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-32142, MGI:2144058
References
more
  • Summaries
    All 57
    Developmental Gene Expression 16
    Diseases 1
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:21119 Maser RL, et al., Mouse plasma glutathione peroxidase. cDNA sequence analysis and renal proximal tubular expression and secretion. J Biol Chem. 1994 Oct 28;269(43):27066-73
  • Latest
    J:219003 Hill KE, et al., Selenoprotein P is the major selenium transport protein in mouse milk. PLoS One. 2014;9(7):e103486

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory