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Gpx3
Gene Detail
Symbol

Name
ID
Gpx3
glutathione peroxidase 3
MGI:105102
Synonyms
EGPx, extracellular GPx, GPx, plasma GPx
Feature Type
protein coding gene
Genetic Map
Chromosome 11
32.13 cM, cytoband B3-B5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:54902453-54910377 bp, + strand
From VEGA annotation of GRCm38

  7925 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GPX3
Protein SuperFamily: glutathione peroxidase
Gene Tree: Gpx3

Human
homologs
GPX3, glutathione peroxidase 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2878
neXtProt AC: NX_P22352

Human Synonyms: GPx-P, GSHPx-3, GSHPx-P

Human Chr (Location): 5q33.1; chr5:151020438-151028993 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving Gpx3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced glutathione peroxidase activity, increase plasma selenium levels when mice are fed a selenium supplemented diet, and reduced kidney selenium levels regardless of selenium supplementation.
 
Interactions
Gpx3 interacts with 122 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process glutathione metabolic process, hydrogen peroxide catabolic process, ...
Component extracellular exosome, extracellular region, ...
Function glutathione binding, glutathione peroxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (163)    Tissues (108)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 152
RT-PCR 11
cDNA source data(1579)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gpx3 ; ZFIN gpx3    NEW 
Molecular
reagents
All nucleic(1584) Genomic(1) cDNA(1580) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006337 (Evidence)
Ensembl Gene Model ENSMUSG00000018339 (Evidence)
Entrez Gene 14778 (Evidence)
UniGene 200916
DFCI TC1573658
DoTS DT.91302890, DT.87073053, DT.101741046, DT.101307530, DT.94160987, DT.94161010
NIA Mouse Gene Index U012621
EC 1.11.1.9
Consensus CDS Project CCDS24703.1
International Mouse Phenotyping Consortium Status Gpx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006337 VEGA Gene Model | MGI Sequence Detail 7925 C57BL/6J ±  kb
transcript OTTMUST00000014399 VEGA | MGI Sequence Detail 1594 Not Applicable 
polypeptide OTTMUSP00000006678 VEGA | MGI Sequence Detail 226 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(3) UniProt(3)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000889 Glutathione peroxidase
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008212 glutathione peroxidase 3
References
(Earliest) J:21119 Maser RL, et al., Mouse plasma glutathione peroxidase. cDNA sequence analysis and renal proximal tubular expression and secretion. J Biol Chem. 1994 Oct 28;269(43):27066-73
(Latest) J:219003 Hill KE, et al., Selenoprotein P is the major selenium transport protein in mouse milk. PLoS One. 2014;9(7):e103486
All references(59)
Other
accession IDs
MGD-MRK-32142, MGI:2144058

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory