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Gpx3
Gene Detail
Symbol

Name
ID
Gpx3
glutathione peroxidase 3
MGI:105102
Synonyms
EGPx, extracellular GPx, GPx, plasma GPx
Feature Type
protein coding gene
Genetic Map
Chromosome 11
32.13 cM, cytoband B3-B5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:54902453-54910377 bp, + strand
From VEGA annotation of GRCm38

  7925 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glutathione peroxidase
Gene Tree: Gpx3

Human
homologs
Human Homolog GPX3, glutathione peroxidase 3 (plasma)
NCBI Gene ID 2878
neXtProt AC  NX_P22352
Human Synonyms  GPx-P, GSHPx-3, GSHPx-P
Human Chr (Location)  5q23; chr5:151020438-151028993 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Gpx3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced glutathione peroxidase activity, increase plasma selenium levels when mice are fed a selenium supplemented diet, and reduced kidney selenium levels regardless of selenium supplementation.
 
Interactions
Gpx3 interacts with 122 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process glutathione metabolic process, hydrogen peroxide catabolic process, ...
Component extracellular region, extracellular space, ...
Function glutathione binding, glutathione peroxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (163)    Tissues (108)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 152
RT-PCR 11
cDNA source data(1579)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(1584) Genomic(1) cDNA(1580) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006337 (Evidence)
Ensembl Gene ModelENSMUSG00000018339 (Evidence)
Entrez Gene14778 (Evidence)
UniGene200916
DFCITC1573658
DoTSDT.101741046, DT.101307530, DT.87073053, DT.94160987, DT.91302890, DT.94161010
NIA Mouse Gene IndexU012621
EC1.11.1.9
Consensus CDS ProjectCCDS24703.1
International Mouse Knockout Project StatusGpx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006337 VEGA Gene Model | MGI Sequence Detail 7925 C57BL/6J ±  kb
transcript OTTMUST00000014399 VEGA | MGI Sequence Detail 1594 Not Applicable 
polypeptide OTTMUSP00000006678 VEGA | MGI Sequence Detail 226 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(3) UniProt(5)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000889 Glutathione peroxidase
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008212 glutathione peroxidase 3
References
(Earliest) J:41429 Chu FF, et al., Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents. Blood. 1992 Jun 15;79(12):3233-8
(Latest) J:203560 Burk RF, et al., Maternal-fetal transfer of selenium in the mouse. FASEB J. 2013 Aug;27(8):3249-56
All references(57)
Other
accession IDs
MGD-MRK-32142, MGI:2144058

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory