Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables glutathione peroxidase activity. Acts upstream of or within cellular oxidant detoxification and hydrogen peroxide catabolic process. Located in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; cerebral infarction; gastrointestinal system cancer (multiple); multiple myeloma; and type 2 diabetes mellitus. Orthologous to human GPX3 (glutathione peroxidase 3).