About   Help   FAQ
Pdcd1
Gene Detail
 Symbol
Name
ID
Pdcd1
programmed cell death 1
MGI:104879
Synonyms PD-1, Pdc1
Feature Type protein coding gene
Genetic Map
Chromosome 1
47.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:94038307-94052553 bp, - strand
From Ensembl annotation of GRCm38

  14247 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3681  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Pdcd1

Human
homologs
Human Homolog PDCD1, programmed cell death 1
NCBI Gene ID 5133
neXtProt AC  NX_Q15116
Human Synonyms  CD279, hPD-1, hPD-l, hSLE1, PD1, PD-1, SLEB2
Human Chr (Location)  2q37.3; chr2:241849881-241858908 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display abnormalities in leukopoiesis and the immune system which vary considerably depending on the genetic background.
 
Human Diseases Modeled Using Mouse Pdcd1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Pdcd1 interacts with 166 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process apoptotic process, immune system process
Component external side of plasma membrane, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026285 (Evidence)
Entrez Gene18566 (Evidence)
UniGene5024
DFCITC1589965
DoTSDT.55131714
NIA Mouse Gene IndexU021620
PDB1NPU, 3BIK, 3RNK, 3RNQ, 3SBW, 3BP5, 3BP6
Consensus CDS ProjectCCDS15200.1
International Mouse Knockout Project StatusPdcd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026285 Ensembl Gene Model | MGI Sequence Detail 14247 C57BL/6J ±  kb
transcript ENSMUST00000027507 Ensembl | MGI Sequence Detail 1928 Not Applicable 
polypeptide ENSMUSP00000027507 Ensembl | MGI Sequence Detail 288 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(186 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001919 programmed cell death protein 1
References (Earliest) J:35861 Ishida Y, et al., Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992 Nov;11(11):3887-95
(Latest) J:209397 Arora P, et al., A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity. 2014 Jan 16;40(1):105-16
All references(150)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-13206, MGD-MRK-29032

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory