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Pdcd1
Gene Detail
Symbol

Name
ID
Pdcd1
programmed cell death 1
MGI:104879
Synonyms
PD-1, Pdc1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
47.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:94038305-94052553 bp, - strand
From VEGA annotation of GRCm38

  14249 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3681  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: PDCD1
Gene Tree: Pdcd1

Human
homologs
PDCD1, programmed cell death 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5133
neXtProt AC: NX_Q15116

Human Synonyms: CD279, hPD-1, hPD-l, hSLE1, PD1, PD-1, SLEB2

Human Chr (Location): 2q37.3; chr2:241849881-241858908 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display abnormalities in leukopoiesis and the immune system which vary considerably depending on the genetic background.
 
Human Diseases Modeled in Mice Using Pdcd1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Pdcd1 interacts with 166 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process apoptotic process, immune system process, ...
Component external side of plasma membrane, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000048696 (Evidence)
Ensembl Gene Model ENSMUSG00000026285 (Evidence)
Entrez Gene 18566 (Evidence)
UniGene 5024
DFCI TC1589965
DoTS DT.55131714
NIA Mouse Gene Index U021620
PDB 3RNK, 3BP6, 3BIK, 1NPU, 3RNQ, 3BP5, 3SBW
Consensus CDS Project CCDS15200.1
International Mouse Phenotyping Consortium Status Pdcd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048696 VEGA Gene Model | MGI Sequence Detail 14249 C57BL/6J ±  kb
transcript OTTMUST00000124694 VEGA | MGI Sequence Detail 1930 Not Applicable 
polypeptide OTTMUSP00000067809 VEGA | MGI Sequence Detail 288 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(186 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001919 programmed cell death protein 1
References
(Earliest) J:35861 Ishida Y, et al., Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992 Nov;11(11):3887-95
(Latest) J:221793 Okamura T, et al., TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Nat Commun. 2015;6:6329
All references(154)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-13206, MGD-MRK-29032

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory