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Pdcd1
Gene Detail
Symbol

Name
ID
Pdcd1
programmed cell death 1
MGI:104879
Synonyms
PD-1, Pdc1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
47.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:94038305-94052553 bp, - strand
From VEGA annotation of GRCm38

  14249 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3681  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Pdcd1

Human
homologs
Human Homolog PDCD1, programmed cell death 1
NCBI Gene ID 5133
neXtProt AC  NX_Q15116
Human Synonyms  CD279, hPD-1, hPD-l, hSLE1, PD1, PD-1, SLEB2
Human Chr (Location)  2q37.3; chr2:241849881-241858908 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display abnormalities in leukopoiesis and the immune system which vary considerably depending on the genetic background.
 
Human Diseases Modeled Using Mouse Pdcd1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Pdcd1 interacts with 166 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process apoptotic process, immune system process, ...
Component external side of plasma membrane, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000048696 (Evidence)
Ensembl Gene ModelENSMUSG00000026285 (Evidence)
Entrez Gene18566 (Evidence)
UniGene5024
DFCITC1589965
DoTSDT.55131714
NIA Mouse Gene IndexU021620
PDB3BIK, 1NPU, 3RNK, 3SBW, 3RNQ, 3BP6, 3BP5
Consensus CDS ProjectCCDS15200.1
International Mouse Knockout Project StatusPdcd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048696 VEGA Gene Model | MGI Sequence Detail 14249 C57BL/6J ±  kb
transcript OTTMUST00000124694 VEGA | MGI Sequence Detail 1930 Not Applicable 
polypeptide OTTMUSP00000067809 VEGA | MGI Sequence Detail 288 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(186 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001919 programmed cell death protein 1
References
(Earliest) J:35861 Ishida Y, et al., Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992 Nov;11(11):3887-95
(Latest) J:211871 Park SJ, et al., Negative role of inducible PD-1 on survival of activated dendritic cells. J Leukoc Biol. 2014 Apr;95(4):621-9
All references(155)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-13206, MGD-MRK-29032

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory