Pdcd1
Gene Detail

Symbol Name ID

Pdcd1 programmed cell death 1 MGI:104879

Synonyms

PD-1, Pdc1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

47.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:94038307-94052553 bp, - strand From Ensembl annotation of GRCm38   14247 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Pdcd1

Human homologs

Human Homolog		PDCD1, programmed cell death 1
NCBI Gene ID		5133
neXtProt AC		NX_Q15116
Human Synonyms		CD279, hPD-1, hPD-l, PD1, PD-1, SLEB2
Human Chr (Location)		2q37.3; chr2:242792033-242801058 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PDCD1

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for disruptions in this gene display abnormalities in leukopoiesis and the immune system which vary considerably depending on the genetic background.

 
Human Diseases Modeled Using Mouse Pdcd1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	apoptotic process
Component	external side of plasma membrane, integral to membrane, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(4) cDNA(4)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000026285 (Evidence)
Entrez Gene	18566 (Evidence)
UniGene	5024
DFCI	TC1589965
DoTS	DT.55131714
NIA Mouse Gene Index	U021620
PDB	1NPU, 3BIK, 3RNK, 3RNQ, 3SBW, 3BP5, 3BP6
Consensus CDS Project	CCDS15200.1
International Mouse Knockout Project Status	Pdcd1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000026285	Ensembl Gene Model | MGI Sequence Detail	14247	C57BL/6J
transcript	ENSMUST00000027507	Ensembl | MGI Sequence Detail	1928	Not Applicable
polypeptide	ENSMUSP00000027507	Ensembl | MGI Sequence Detail	288	Not Applicable

All sequences(15) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(65 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000001919	programmed cell death protein 1

References

(Earliest) J:35861 Ishida Y, et al., Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992 Nov;11(11):3887-95
(Latest) J:190843 Iwamoto S, et al., TNF-alpha is essential in the induction of fatal autoimmune hepatitis in mice through upregulation of hepatic CCL20 expression. Clin Immunol. 2013 Jan;146(1):15-25
All references(134)

Other accession IDs

MGD-MRK-13206, MGD-MRK-29032