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Phenotypes Associated with This Genotype
Genotype
MGI:3054645
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
C.129S2(B6)-Pdcd1tm1Hon
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• massively enlarged hearts at death
• varying degrees of hepatomegaly

mortality/aging
• start to die around 5 weeks of age, 2/3 are dead by 30 weeks

cardiovascular system
• massively enlarged hearts at death
• thin right venricular wall
• both ventricles dilated to about 2X normal diameter
• sporatic fibrosis and scar formation
• impaired pump function of the heart
• reduced movement of the ventricular walls and interventricular septum

immune system
• higher titers of autoantibodies (IgG1)
• deposition of IgG and C3 complement around cardiomyocytes

liver/biliary system
• varying degrees of hepatomegaly

muscle
• reduced movement of the ventricular walls and interventricular septum

vision/eye
• protrusion of eyeballs occurs a few weeks before death

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:66979


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory