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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Pdcd1
programmed cell death 1
MGI:104879
45 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Pdcd1tm1.1Liux/Pdcd1tm1.1Liux
involves: C57BL/6
decreased cell proliferation J:190150
decreased regulatory T cell number J:190150
decreased sensitivity to induced morbidity/mortality J:190150
decreased tumor growth/size J:190150
increased apoptosis J:190150
increased T-helper 1 cell number J:190150
Pdcd1tm1.1Shr/Pdcd1tm1.1Shr
involves: C57BL/6
decreased B-1 B cell number J:153040
increased regulatory T cell number J:153040
increased retina ganglion cell number J:154546
Pdcd1tm1Hon/Pdcd1tm1Hon
B6.129S2-Pdcd1tm1Hon
abnormal response to transplant J:119356
arthritis J:78802
glomerulonephritis J:78802
Pdcd1tm1Hon/Pdcd1tm1Hon
C.129S2(B6)-Pdcd1tm1Hon
abnormal cardiac muscle contractility J:66979
abnormal cardiac output J:66979
abnormal cardiovascular system physiology J:66979
abnormal heart morphology J:66979
cardiac fibrosis J:66979
dilated heart ventricle J:66979
enlarged heart J:66979
enlarged liver J:66979
exophthalmos J:66979
increased autoantibody level J:66979
premature death J:66979
thin ventricular wall J:66979
Pdcd1tm1Hon/Pdcd1tm1Hon
involves: 129S2/SvPas
abnormal T cell activation J:222944
hepatic necrosis J:222944
increased IgA level J:222944
increased IgM level J:222944
increased inflammatory response J:222944
increased interferon-gamma secretion J:222944
pancreas necrosis J:222944
pulmonary necrosis J:222944
Pdcd1tm1Hon/Pdcd1tm1Hon
involves: 129S2/SvPas * C57BL/6
abnormal immunoglobulin level J:50688
abnormal leukopoiesis J:50688
abnormal myelopoiesis J:50688
enlarged spleen J:50688
increased B cell number J:50688
increased B cell proliferation J:50688
increased B-1 B cell number J:50688
increased IgA level J:50688
increased IgG2b level J:50688
increased IgG3 level J:50688
increased lymphocyte cell number J:50688
Pdcd1tm1Llc/Pdcd1tm1Llc
involves: 129S5/SvEvBrd
abnormal cytokine secretion J:126829
decreased CD8-positive, alpha-beta T cell number J:126829
increased susceptibility to experimental autoimmune encephalomyelitis J:126829

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory