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Targeted Allele Detail
Symbol: Pdcd1tm1.1Liux
Name: programmed cell death 1; targeted mutation 1.1, Xiaolong Liu
MGI ID: MGI:5449635
Synonyms: Pdcd1KI
Gene: Pdcd1  Location: Chr1:93966027-93980278 bp, - strand  Genetic Position: Chr1, 47.47 cM
Alliance: Pdcd1tm1.1Liux page
Decreased tumor growth in Pdcd1tm1.1Liux/Pdcd1tm1.1Liux mice following carcinoma cell inoculation

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:190150
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsNucleotide substitutions (CCTAGTAC to TATGCGAC) disrupts the AP-1-binding site D of the proximal conserved region. Cre-mediated recombination removed the floxed neo cassette inserted downstream of the mutation site. (J:190150)
Generation of the Pdcd1tm1.1Liux allele
View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Pdcd1tm1.1Liux
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdcd1 Mutation:  69 strains or lines available
Original:  J:190150 Xiao G, et al., Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15419-24
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory