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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdcd1tm1.1Liux
targeted mutation 1.1, Xiaolong Liu
MGI:5449635
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pdcd1tm1.1Liux/Pdcd1tm1.1Liux involves: C57BL/6 MGI:5449726
cn2
 		Pdcd1tm1.1Liux/Pdcd1tm1.1Liux
Tg(MMTV-PyVT)634Mul/0 		involves: C57BL/6 * FVB/N MGI:5449727


Genotype
MGI:5449726
hm1
Allelic
Composition		 Pdcd1tm1.1Liux/Pdcd1tm1.1Liux
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1.1Liux mutation (0 available); any Pdcd1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Decreased tumor growth in Pdcd1tm1.1Liux/Pdcd1tm1.1Liux mice following carcinoma cell inoculation

mortality/aging

neoplasm
decreased tumor growth/size ( J:190150 )
• decreased lung tumor number and growth following inoculation with Lewis lung carcinoma or B16-F10 melanoma

immune system
increased T-helper 1 cell number ( J:190150 )
• in tumor following inoculation with Lewis lung carcinoma
decreased regulatory T cell number ( J:190150 )
• in tumor following inoculation with Lewis lung carcinoma

cellular
increased apoptosis ( J:190150 )
• in tumor cells following inoculation with Lewis lung carcinoma or B16-F10 melanoma
decreased cell proliferation ( J:190150 )
• in tumor cells following inoculation with Lewis lung carcinoma or B16-F10 melanoma

hematopoietic system
increased T-helper 1 cell number ( J:190150 )
• in tumor following inoculation with Lewis lung carcinoma
decreased regulatory T cell number ( J:190150 )
• in tumor following inoculation with Lewis lung carcinoma




Genotype
MGI:5449727
cn2
Allelic
Composition		 Pdcd1tm1.1Liux/Pdcd1tm1.1Liux
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1.1Liux mutation (0 available); any Pdcd1 mutation (48 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Reduced tumor growth in Pdcd1tm1.1Liux/Pdcd1tm1.1Liux Tg(MMTV-PyVT)634Mul/0 mice

mortality/aging
extended life span ( J:190150 )
• mice survive longer than Pdcd1+/Pdcd1tm1.1Liux Tg(MMTV-PyVT)634Mul mice

neoplasm
decreased tumor growth/size ( J:190150 )
• reduced tumor growth compared to in Pdcd1+/Pdcd1tm1.1Liux Tg(MMTV-PyVT)634Mul mice
increased tumor latency ( J:190150 )
• compared with Pdcd1+/Pdcd1tm1.1Liux Tg(MMTV-PyVT)634Mul mice

immune system
increased T-helper 1 cell number ( J:190150 )
• in tumors 0447. smb 1/21/13
increased interferon-gamma secretion ( J:190150 )
• in tumor-infiltrating CD4+ and CD8+ T cells
decreased interleukin-17 secretion ( J:190150 )
• of Il17a in tumor-infiltrating CD4+ T cells
increased interleukin-2 secretion ( J:190150 )
• in tumor-infiltrating CD4+ and CD8+ T cells
increased tumor necrosis factor secretion ( J:190150 )
• in tumor-infiltrating CD4+ and CD8+ T cells

cellular
increased apoptosis ( J:190150 )
• of tumor cells compared to in Pdcd1+/Pdcd1tm1.1Liux Tg(MMTV-PyVT)634Mul mice

hematopoietic system
increased T-helper 1 cell number ( J:190150 )
• in tumors 0447. smb 1/21/13




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory