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Targeted Allele Detail
Symbol: Pdcd1tm1.1Shr
Name: programmed cell death 1; targeted mutation 1.1, Arlene H Sharpe
MGI ID: MGI:4397682
Synonyms: PD-1-
Gene: Pdcd1  Location: Chr1:93966027-93980278 bp, - strand  Genetic Position: Chr1, 47.47 cM
Alliance: Pdcd1tm1.1Shr page
Germline Transmission:  Earliest citation of germline transmission: J:153040
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 3. Transient cre expression in ES cells removed exons 2 and 3 along with the neo cassette. (J:153040)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Pdcd1 Mutation:  69 strains or lines available
Original:  J:153040 Keir ME, et al., PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues. J Immunol. 2007 Oct 15;179(8):5064-70
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory