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Jarid2 Gene Detail
Summary
  • Symbol
    Jarid2
  • Name
    jumonji, AT rich interactive domain 2
  • Synonyms
    Jmj, jumonji
  • Feature Type
    protein coding gene
  • IDs
    MGI:104813
    NCBI Gene: 16468
  • Gene Overview
    MyGene.info: JARID2
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:44729535-44921643 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 21.66 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    783 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104813
protein coding gene Chr13:44729474-44921643 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020504
protein coding gene Chr13:43403726-43608739 (+)
A/J MGP_AJ_G0020458
protein coding gene Chr13:41902944-42098482 (+)
AKR/J MGP_AKRJ_G0020436
protein coding gene Chr13:43065999-43277768 (+)
BALB/cJ MGP_BALBcJ_G0020454
protein coding gene Chr13:42115407-42309382 (+)
C3H/HeJ MGP_C3HHeJ_G0020253
protein coding gene Chr13:42916692-43119867 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020887
protein coding gene Chr13:44728112-44940238 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018474
protein coding gene Chr13:39989849-40177451 (+)
CAST/EiJ MGP_CASTEiJ_G0019768
protein coding gene Chr13:42795886-42993703 (+)
CBA/J MGP_CBAJ_G0020214
protein coding gene Chr13:46608746-46833858 (+)
DBA/2J MGP_DBA2J_G0020336
protein coding gene Chr13:41465691-41663730 (+)
FVB/NJ MGP_FVBNJ_G0020315
protein coding gene Chr13:40990029-41184347 (+)
LP/J MGP_LPJ_G0020411
protein coding gene Chr13:43635358-43837831 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020344
protein coding gene Chr13:46477993-46691268 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020930
protein coding gene Chr13:42736024-42932209 (+)
PWK/PhJ MGP_PWKPhJ_G0019523
protein coding gene Chr13:41588448-41784622 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019353
protein coding gene Chr13:41399954-41587372 (+)
WSB/EiJ MGP_WSBEiJ_G0019830
protein coding gene Chr13:43044143-43244429 (+)



Homology
more
  • Human Ortholog
    JARID2, jumonji and AT-rich interaction domain containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    JARID2, jumonji and AT-rich interaction domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JMJ
  • Links
    NCBI Gene ID: 3720
    neXtProt AC: NX_Q92833
    UniProt: Q92833

  • Chr Location
    6p22.3; chr6:15245975-15522042 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31279
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: JARID2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    56 phenotypes from 5 alleles in 8 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants show strain-specific phenotypes, including embryonic death and defective neural tube closure, impaired hematopoiesis and hypoplasia of liver, thymus and spleen. Homozygotes for another mutation die at birth with cardiac defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16468 NCBI Gene Model | MGI Sequence Detail 192109 C57BL/6J ±  kb
    transcript NM_001205043 RefSeq | MGI Sequence Detail 5997 C57BL/6  
    polypeptide Q62315 UniProt | EBI | MGI Sequence Detail 1234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 26
      Primer pair 7
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-28107, MGI:2139495, MGI:2145204, MGI:2145380, MGI:2145512
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 30
      Gene Ontology 18
      Phenotypes 38
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:262237 Conway E, et al., A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Mol Cell. 2018 May 3;70(3):408-421.e8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory