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Jarid2
Gene Detail
Symbol

Name
ID
Jarid2
jumonji, AT rich interactive domain 2
MGI:104813
Synonyms
Jmj, jumonji
Feature Type
protein coding gene
Genetic Map
Chromosome 13
21.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:44729474-44921643 bp, + strand
From VEGA annotation of GRCm38

  192170 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31279  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Jarid2

Human
homologs
Human Homolog JARID2, Jumonji, AT rich interactive domain 2
NCBI Gene ID 3720
neXtProt AC  NX_Q92833
Human Synonyms  JMJ
Human Chr (Location)  6p24-p23; chr6:15245975-15522042 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(513) : Gene trapped(509) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants show strain-specific phenotypes, including embryonic death and defective neural tube closure, impaired hematopoiesis and hypoplasia of liver, thymus and spleen. Homozygotes for another mutation die at birth with cardiac defects.
 
Interactions
Jarid2 interacts with 353 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell differentiation, chromatin modification, ...
Component ESC/E(Z) complex, histone methyltransferase complex, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (243)    Tissues (168)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 164
In situ reporter (knock in) 22
Northern blot 2
Western blot 4
RT-PCR 50
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(1) cDNA(24) Primer pair(5)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000037582 (Evidence)
Ensembl Gene ModelENSMUSG00000038518 (Evidence)
Entrez Gene16468 (Evidence)
DFCITC1574089, TC1673942, TC1718745
DoTSDT.101266865, DT.101330033, DT.534118, DT.101738666, DT.101362275, DT.91401378, DT.97362236, DT.94359800
NIA Mouse Gene IndexU014782
PDB2RQ5
Consensus CDS ProjectCCDS36646.1
International Mouse Knockout Project StatusJarid2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037582 VEGA Gene Model | MGI Sequence Detail 192170 C57BL/6J ±  kb
transcript OTTMUST00000096890 VEGA | MGI Sequence Detail 4135 Not Applicable 
polypeptide OTTMUSP00000054202 VEGA | MGI Sequence Detail 1234 Not Applicable 

For the selected sequences
All sequences(124) RefSeq(18) UniProt(17)
Polymorphisms
PCR(1) : SNPs within 2kb(787 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001606 ARID/BRIGHT DNA-binding domain
InterPro IPR003347 JmjC domain
InterPro IPR003349 Transcription factor jumonji, JmjN
InterPro IPR004198 Zinc finger, C5HC2-type
Protein Ontology PR:000009208 protein Jumonji
References
(Earliest) J:25641 Takeuchi T, et al., Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev. 1995 May 15;9(10):1211-22
(Latest) J:213028 Kaneko S, et al., Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin. Mol Cell. 2014 Jan 23;53(2):290-300
All references(88)
Other
accession IDs
MGD-MRK-28107, MGI:2139495, MGI:2145204, MGI:2145380, MGI:2145512

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory