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Jarid2
Gene Detail
Symbol

Name
ID
Jarid2
jumonji, AT rich interactive domain 2
MGI:104813
Synonyms
Jmj, jumonji
Feature Type
protein coding gene
Genetic Map
Chromosome 13
21.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:44729474-44921643 bp, + strand
From VEGA annotation of GRCm38

  192170 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31279  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: JARID2
Gene Tree: Jarid2

Human
homologs
JARID2, Jumonji, AT rich interactive domain 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3720
neXtProt AC: NX_Q92833

Human Synonyms: JMJ

Human Chr (Location): 6p24-p23; chr6:15245975-15522042 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(513) : Gene trapped(509) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants show strain-specific phenotypes, including embryonic death and defective neural tube closure, impaired hematopoiesis and hypoplasia of liver, thymus and spleen. Homozygotes for another mutation die at birth with cardiac defects.
 
Interactions
Jarid2 interacts with 352 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cell differentiation, chromatin modification, ...
Component ESC/E(Z) complex, histone methyltransferase complex, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (252)    Tissues (172)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 172
In situ reporter (knock in) 22
Northern blot 2
Western blot 4
RT-PCR 51
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase jarid2    NEW 
Molecular
reagents
All nucleic(33) Genomic(1) cDNA(25) Primer pair(7)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000037582 (Evidence)
Ensembl Gene Model ENSMUSG00000038518 (Evidence)
Entrez Gene 16468 (Evidence)
DFCI TC1574089, TC1673942, TC1718745
DoTS DT.101266865, DT.101330033, DT.94359800, DT.91401378, DT.101362275, DT.534118, DT.101738666, DT.97362236
NIA Mouse Gene Index U014782
PDB 2RQ5
Consensus CDS Project CCDS36646.1
International Mouse Phenotyping Consortium Status Jarid2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037582 VEGA Gene Model | MGI Sequence Detail 192170 C57BL/6J ±  kb
transcript OTTMUST00000096890 VEGA | MGI Sequence Detail 4135 Not Applicable 
polypeptide OTTMUSP00000054202 VEGA | MGI Sequence Detail 1234 Not Applicable 

For the selected sequences
All sequences(115) RefSeq(16) UniProt(9)
Polymorphisms
PCR(1) : SNPs within 2kb(787 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001606 ARID/BRIGHT DNA-binding domain
InterPro IPR003347 JmjC domain
InterPro IPR003349 Transcription factor jumonji, JmjN
InterPro IPR004198 Zinc finger, C5HC2-type
Protein Ontology PR:000009208 protein Jumonji
References
(Earliest) J:25641 Takeuchi T, et al., Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev. 1995 May 15;9(10):1211-22
(Latest) J:222052 Kinkel SA, et al., Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2. Blood. 2015 Mar 19;125(12):1890-900
All references(88)
Other
accession IDs
MGD-MRK-28107, MGI:2139495, MGI:2145204, MGI:2145380, MGI:2145512

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory