About   Help   FAQ
Ephb4 Gene Detail
Summary
  • Symbol
    Ephb4
  • Name
    Eph receptor B4
  • Synonyms
    b2b2412Clo, Htk, MDK2, Myk1, Tyro11
  • Feature Type
    protein coding gene
  • IDs
    MGI:104757
    NCBI Gene: 13846
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137348371-137372784 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104757
protein coding gene Chr5:137348371-137376931 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030225
protein coding gene Chr5:142087355-142119516 (+)
A/J MGP_AJ_G0030193
protein coding gene Chr5:135907084-135936687 (+)
AKR/J MGP_AKRJ_G0030126
protein coding gene Chr5:140311834-140342196 (+)
BALB/cJ MGP_BALBcJ_G0030203
protein coding gene Chr5:137274039-137304571 (+)
C3H/HeJ MGP_C3HHeJ_G0029919
protein coding gene Chr5:140963198-140993764 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030655
protein coding gene Chr5:147355024-147387763 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027873
protein coding gene Chr5:130156288-130183798 (+)
CAST/EiJ MGP_CASTEiJ_G0029329
protein coding gene Chr5:140363901-140398314 (+)
CBA/J MGP_CBAJ_G0029889
protein coding gene Chr5:153194691-153223392 (+)
DBA/2J MGP_DBA2J_G0030040
protein coding gene Chr5:135810529-135839528 (+)
FVB/NJ MGP_FVBNJ_G0029995
protein coding gene Chr5:135003373-135035377 (+)
LP/J MGP_LPJ_G0030129
protein coding gene Chr5:142554668-142585118 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030027
protein coding gene Chr5:156035869-156065324 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030696
protein coding gene Chr5:140165524-140195755 (+)
PWK/PhJ MGP_PWKPhJ_G0029042
protein coding gene Chr5:134889756-134919994 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028878
protein coding gene Chr5:137725784-137763868 (+)
WSB/EiJ MGP_WSBEiJ_G0029402
protein coding gene Chr5:140897354-140927393 (+)



Homology
more
  • Human Ortholog
    EPHB4, EPH receptor B4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHB4, EPH receptor B4
  • Synonyms
    CMAVM2, HFASD, HTK, LMPHM7, MYK1, TYRO11
  • Links
    NCBI Gene ID: 2050
    neXtProt AC: NX_P54760
    UniProt: P54760

  • Chr Location
    7q22.1; chr7:100802565-100827523 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Ephb4 mouse models; 1 with human EPHB4 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    10 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit arrested angiogenesis and heart development and midgestational lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13846 NCBI Gene Model | MGI Sequence Detail 24414 C57BL/6J ±  kb
    transcript NM_001159571 RefSeq | MGI Sequence Detail 4361 C57BL/6  
    polypeptide P54761 UniProt | EBI | MGI Sequence Detail 987 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000007132 ephrin type-B receptor 4
    • EC
    • InterPro Domains
      IPR037636 EPH-B4, SAM domain
      IPR001090 Ephrin receptor ligand binding domain
      IPR027936 Ephrin receptor, transmembrane domain
      IPR016257 Ephrin receptor type-A /type-B
      IPR034290 Ephrin type-B receptor 4, ligand binding domain
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
      IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 77
      Primer pair 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28048, MGI:2140802, MGI:5614902
    References
    more
    • Summaries
      All 183
      Developmental Gene Expression 110
      Diseases 1
      Gene Ontology 8
      Phenotypes 41
    • Earliest
      J:17851 Andres AC, et al., Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis [published erratum appears in Oncogene 1994 Aug;9(8):2431]. Oncogene. 1994 May;9(5):1461-7
    • Latest
      J:342872 Zhao S, et al., Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations. Nat Commun. 2023 Nov 17;14(1):7452

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory