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Ephb4
Gene Detail
Symbol

Name
ID
Ephb4
Eph receptor B4
MGI:104757
Synonyms
Htk, MDK2, Myk1, Tyro11
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:137350109-137378669 bp, + strand
From VEGA annotation of GRCm38

  28561 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20939  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

HCOP human homology predictions: EPHB4
Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Ephb4

Human
homologs
EPHB4, EPH receptor B4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2050
neXtProt AC: NX_P54760

Human Synonyms: HTK, MYK1, TYRO11

Human Chr (Location): 7q22; chr7:100802565-100827521 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit arrested angiogenesis and heart development and midgestational lethality.
 
Interactions
Ephb4 interacts with 144 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process angiogenesis, cell adhesion, ...
Component extracellular exosome, integral component of membrane, ...
Function ATP binding, ephrin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (76 records)
Data Summary: Results (110)    Tissues (75)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 51
In situ reporter (knock in) 3
RT-PCR 56
cDNA source data(73)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100497297 ; ZFIN ephb4a, ephb4b    NEW 
Molecular
reagents
All nucleic(78) cDNA(73) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021937 (Evidence)
Ensembl Gene Model ENSMUSG00000029710 (Evidence)
Entrez Gene 13846 (Evidence)
UniGene 34533
DFCI TC1581360, TC1595859, TC1641366
DoTS DT.101409643, DT.101706433, DT.489743, DT.94371451, DT.97375097
NIA Mouse Gene Index U006318
EC 2.7.10.1
Consensus CDS Project CCDS19767.1, CCDS51671.1
International Mouse Phenotyping Consortium Status Ephb4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021937 VEGA Gene Model | MGI Sequence Detail 28561 C57BL/6J ±  kb
transcript OTTMUST00000052078 VEGA | MGI Sequence Detail 4296 Not Applicable 
polypeptide OTTMUSP00000024618 VEGA | MGI Sequence Detail 996 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR011510 Sterile alpha motif, type 2
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007132 ephrin type-B receptor 4
References
(Earliest) J:17851 Andres AC, et al., Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis [published erratum appears in Oncogene 1994 Aug;9(8):2431]. Oncogene. 1994 May;9(5):1461-7
(Latest) J:222563 Wang Y, et al., EPHB4 Protein Expression in Vascular Smooth Muscle Cells Regulates Their Contractility, and EPHB4 Deletion Leads to Hypotension in Mice. J Biol Chem. 2015 May 29;290(22):14235-44
All references(125)
Other
accession IDs
MGD-MRK-28048, MGI:2140802

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory