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Ephb4 Gene Detail
Summary
  • Symbol
    Ephb4
  • Name
    Eph receptor B4
  • Synonyms
    Htk, MDK2, Myk1, Tyro11
  • Feature Type
    protein coding gene
  • IDs
    MGI:104757
    NCBI Gene: 13846
  • Gene Overview
    MyGene.info: EPHB4
Location & Maps
more
  • Sequence Map
    Chr5:137350109-137378669 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28561 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.38 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EPHB4, EPH receptor B4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EPHB4, EPH receptor B4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HTK, MYK1, TYRO11
  • Links
    NCBI Gene ID: 2050
    neXtProt AC: NX_P54760

  • Chr Location
    7q22.1; chr7:100802565-100827521 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit arrested angiogenesis and heart development and midgestational lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021937 VEGA Gene Model | MGI Sequence Detail 28561 C57BL/6J ±  kb
transcript OTTMUST00000052078 VEGA | MGI Sequence Detail 4296 Not Applicable  
polypeptide OTTMUSP00000024618 VEGA | MGI Sequence Detail 996 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    144 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    cDNA 73
    Primer pair 5

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-28048, MGI:2140802
References
more
  • Summaries
    All 130
    Developmental Gene Expression 83
    Gene Ontology 7
    Phenotypes 25
  • Earliest
    J:17851 Andres AC, et al., Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis [published erratum appears in Oncogene 1994 Aug;9(8):2431]. Oncogene. 1994 May;9(5):1461-7
  • Latest
    J:231672 Xavier GM, et al., Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue. Front Physiol. 2016;7:60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory