Nfkbia
Gene Detail

Symbol Name ID

Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha MGI:104741

Synonyms

IkappaBalpha, I-kappaBalpha, I(Kappa)B(alpha), Nfkbi

Feature Type

protein coding gene

Genetic Map

Chromosome 12

24.00 cM, cytoband C1-C3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr12:55489411-55492647 bp, - strand From Ensembl annotation of GRCm38   3237 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7863  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: NF-kappaB inhibitor
Gene Tree: Nfkbia

Human homologs

Human Homolog		NFKBIA, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NCBI Gene ID		4792
neXtProt AC		NX_P25963
Human Synonyms		IKBA, MAD-3, NFKBI
Human Chr (Location)		14q13; chr14:35870716-35873960 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NFKBIA

Alleles and phenotypes

All alleles(11) : Targeted(10) Gene trapped(1)
 

Mice homozygous for disruptions in this gene die at about 1 week of age experiencing abnormalities in the immune system. Mice homozygous for an allele disrupting the N-terminal nuclear export signal exhibit impaired B cell maturation, decreased CD4+ memory T cells, and decreased regulatory T cells.

 
Human Diseases Modeled Using Mouse Nfkbia (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	cytoplasmic sequestering of NF-kappaB, cytoplasmic sequestering of transcription factor, ...
Component	cytoplasm, cytosol, ...
Function	enzyme binding, heat shock protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (99)    Tissues (66)    Images (22)
Theiler Stages: 2, 3, 4, 5, 17, 18, 21, 23, 26, 28

Assay Type	Results
RNA in situ	75
Western blot	9
RT-PCR	15

cDNA source data(116)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(120) Genomic(3) cDNA(116) Primer pair(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000021025 (Evidence)
Entrez Gene	18035 (Evidence)
UniGene	170515
DFCI	TC1579174, TC1628885, TC1714168
DoTS	DT.102557390, DT.492502
NIA Mouse Gene Index	U033960
Consensus CDS Project	CCDS25918.1
International Mouse Knockout Project Status	Nfkbia

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021025	Ensembl Gene Model | MGI Sequence Detail	3237	C57BL/6J
transcript	ENSMUST00000021413	Ensembl | MGI Sequence Detail	1577	Not Applicable
polypeptide	ENSMUSP00000021413	Ensembl | MGI Sequence Detail	314	Not Applicable

All sequences(24) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(16 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
Protein Ontology	PR:000003293	NF-kappa-B inhibitor alpha

References

(Earliest) J:2281 Kawaichi M, et al., Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene. J Biol Chem. 1992 Feb 25;267(6):4016-22
(Latest) J:193958 Huh SH, et al., Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev. 2013 Feb 15;27(4):450-8
All references(132)

Other accession IDs

MGD-MRK-12830, MGD-MRK-28032, MGI:2144835