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Nfkbia
Gene Detail
Symbol

Name
ID
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
MGI:104741
Synonyms
IkappaBalpha, I-kappaBalpha, I(Kappa)B(alpha), Nfkbi
Feature Type
protein coding gene
Genetic Map
Chromosome 12
24.00 cM, cytoband C1-C3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr12:55489411-55492647 bp, - strand
From Ensembl annotation of GRCm38

  3237 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7863  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: NF-kappaB inhibitor
Gene Tree: Nfkbia

Human
homologs
Human Homolog NFKBIA, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NCBI Gene ID 4792
neXtProt AC  NX_P25963
Human Synonyms  IKBA, MAD-3, NFKBI
Human Chr (Location)  14q13; chr14:35401510-35404754 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NFKBIA
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die at about 1 week of age experiencing abnormalities in the immune system. Mice homozygous for an allele disrupting the N-terminal nuclear export signal exhibit impaired B cell maturation, decreased CD4+ memory T cells, and decreased regulatory T cells.
 
Human Diseases Modeled Using Mouse Nfkbia (2)    Alleles Annotated to Human Diseases(2)   
Interactions
Nfkbia interacts with 109 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process cytoplasmic sequestering of NF-kappaB, cytoplasmic sequestering of transcription factor, ...
Component cytoplasm, cytosol, ...
Function enzyme binding, heat shock protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (92)    Tissues (61)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 75
Western blot 9
RT-PCR 8
cDNA source data(115)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(119) Genomic(3) cDNA(115) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000021025 (Evidence)
Entrez Gene18035 (Evidence)
UniGene170515
DFCITC1579174, TC1628885, TC1714168
DoTSDT.102557390, DT.492502
NIA Mouse Gene IndexU033960
Consensus CDS ProjectCCDS25918.1
International Mouse Knockout Project StatusNfkbia
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021025 Ensembl Gene Model | MGI Sequence Detail 3237 C57BL/6J ±  kb
transcript ENSMUST00000021413 Ensembl | MGI Sequence Detail 1577 Not Applicable 
polypeptide ENSMUSP00000021413 Ensembl | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000003293 NF-kappa-B inhibitor alpha
References
(Earliest) J:2281 Kawaichi M, et al., Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene. J Biol Chem. 1992 Feb 25;267(6):4016-22
(Latest) J:210142 Edwards JR, et al., Silent information regulator (Sir)T1 inhibits NF-kappaB signaling to maintain normal skeletal remodeling. J Bone Miner Res. 2013 Apr;28(4):960-9
All references(140)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-12830, MGD-MRK-28032, MGI:2144835

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory