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Nfkbiatm1Stw
Targeted Allele Detail
Summary
Symbol: Nfkbiatm1Stw
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; targeted mutation 1, Colin Stewart
MGI ID: MGI:3616190
Gene: Nfkbia  Location: Chr12:55536195-55539432 bp, - strand  Genetic Position: Chr12, 24.0 cM, cytoband C1-C3
Alliance: Nfkbiatm1Stw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:32527
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Most of the coding sequence of the gene is replaced by a neomycin selection cassette. (J:32527)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfkbia Mutation:  19 strains or lines available
References
Original:  J:32527 Klement JF, et al., IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice. Mol Cell Biol. 1996 May;16(5):2341-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory