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Atoh1 Gene Detail
Summary
  • Symbol
    Atoh1
  • Name
    atonal bHLH transcription factor 1
  • Synonyms
    bHLHa14, Hath1, Math1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104654
    NCBI Gene: 11921
  • Gene Overview
    MyGene.info: ATOH1
Location & Maps
more
  • Sequence Map
    Chr6:64729125-64731245 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2121 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ATOH1, atonal bHLH transcription factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATOH1, atonal bHLH transcription factor 1
    Orthology source: HomoloGene
  • Synonyms
    ATH1, bHLHa14, HATH1, MATH-1
  • Links
    NCBI Gene ID: 474
    neXtProt AC: NX_Q92858

  • Chr Location
    4q22; chr4:93828927-93829991 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31297
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ATOH1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 8 alleles in 8 genetic backgrounds
    14 phenotypes from multigenic genotypes
    2 images
    98 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (ENU)
    1
  • Targeted
    14
  • Transgenic
    1
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations exhibit a decreased cerebellum without folia, and lack cerebellar granule neurons, inner-ear hair cells, D1 interneurons, and goblet, enteroendocrine, and Paneth cells. Mutants fail to breathe properly and die at birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057064 VEGA Gene Model | MGI Sequence Detail 2121 C57BL/6J ±  kb
transcript OTTMUST00000140551 VEGA | MGI Sequence Detail 2121 Not Applicable  
polypeptide OTTMUSP00000073605 VEGA | MGI Sequence Detail 351 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004430 protein atonal homolog 1
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR032661 Protein atonal homologue 1
Molecular
Reagents
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  • All nucleic 40
    Genomic 8
    cDNA 16
    Primer pair 3
    Other 13

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-26094
References
more
  • Summaries
    All 336
    Developmental Gene Expression 243
    Gene Ontology 21
    Phenotypes 98
  • Earliest
    J:24337 Akazawa C, et al., A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J Biol Chem. 1995 Apr 14;270(15):8730-8
  • Latest
    J:228792 Chang H, et al., The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation. Dev Biol. 2016 Jan 1;409(1):181-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory