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Atoh1
Gene Detail
Symbol

Name
ID
Atoh1
atonal homolog 1 (Drosophila)
MGI:104654
Synonyms
bHLHa14, Hath1, Math1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
30.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr6:64729146-64731233 bp, + strand
From Ensembl annotation of GRCm38

  2088 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATOH1
Gene Tree: Atoh1

Human
homologs
ATOH1, atonal bHLH transcription factor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 474
neXtProt AC: NX_Q92858

Human Synonyms: ATH1, bHLHa14, HATH1, MATH-1

Human Chr (Location): 4q22; chr4:93828927-93829991 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(1) Targeted(12)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit a decreased cerebellum without folia, and lack cerebellar granule neurons, inner-ear hair cells, D1 interneurons, and goblet, enteroendocrine, and Paneth cells. Mutants fail to breathe properly and die at birth.
 
Interactions
Atoh1 interacts with 192 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process auditory receptor cell differentiation, auditory receptor cell fate determination, ...
Component nucleus
Function chromatin DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (236 records)
Data Summary: Results (312)    Tissues (156)    Images (156)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 31
RNA in situ 240
In situ reporter (knock in) 30
Northern blot 9
RT-PCR 2
cDNA source data(15)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase atoh1 ; ZFIN atoh1a, atoh1b    NEW 
Molecular
reagents
All nucleic(38) Genomic(8) cDNA(16) Primer pair(2) Other(12)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000073043 (Evidence)
Entrez Gene 11921 (Evidence)
UniGene 57229
DFCI TC1587373
DoTS DT.101254886, DT.60104625
NIA Mouse Gene Index U006955
Consensus CDS Project CCDS20203.1
International Mouse Phenotyping Consortium Status Atoh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073043 Ensembl Gene Model | MGI Sequence Detail 2088 C57BL/6J ±  kb
transcript ENSMUST00000101351 Ensembl | MGI Sequence Detail 2088 Not Applicable 
polypeptide ENSMUSP00000098903 Ensembl | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000004430 protein atonal homolog 1
References
(Earliest) J:24337 Akazawa C, et al., A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J Biol Chem. 1995 Apr 14;270(15):8730-8
(Latest) J:221935 Zhang S, et al., Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies. PLoS Genet. 2015 Jul;11(7):e1005344
All references(323)
Other
accession IDs
MGD-MRK-26094

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory