About   Help   FAQ
Atoh1
Gene Detail
 Symbol
Name
ID
Atoh1
atonal homolog 1 (Drosophila)
MGI:104654
Synonyms bHLHa14, Hath1, Math1
Feature Type protein coding gene
Genetic Map
Chromosome 6
30.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr6:64729146-64731233 bp, + strand
From Ensembl annotation of GRCm38

  2088 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Atoh1

Human
homologs
Human Homolog ATOH1, atonal homolog 1 (Drosophila)
NCBI Gene ID 474
neXtProt AC  NX_Q92858
Human Synonyms  ATH1, bHLHa14, HATH1, MATH-1
Human Chr (Location)  4q22; chr4:93828927-93829991 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Targeted(10)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit a decreased cerebellum without folia, and lack cerebellar granule neurons, inner-ear hair cells, D1 interneurons, and goblet, enteroendocrine, and Paneth cells. Mutants fail to breathe properly and die at birth.
 
Interactions
Atoh1 interacts with 192 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process auditory receptor cell differentiation, auditory receptor cell fate determination, ...
Component nucleus
Function chromatin DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (220 records)
Data Summary: Results (312)    Tissues (156)    Images (156)
Theiler Stages: 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 31
RNA in situ 240
In situ reporter (knock in) 30
Northern blot 9
RT-PCR 2
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(8) cDNA(16) Primer pair(2) Other(12)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000073043 (Evidence)
Entrez Gene11921 (Evidence)
UniGene57229
DFCITC1587373
DoTSDT.101254886, DT.60104625
NIA Mouse Gene IndexU006955
Consensus CDS ProjectCCDS20203.1
International Mouse Knockout Project StatusAtoh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073043 Ensembl Gene Model | MGI Sequence Detail 2088 C57BL/6J ±  kb
transcript ENSMUST00000101351 Ensembl | MGI Sequence Detail 2088 Not Applicable 
polypeptide ENSMUSP00000098903 Ensembl | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000004430 protein atonal homolog 1
References (Earliest) J:24337 Akazawa C, et al., A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J Biol Chem. 1995 Apr 14;270(15):8730-8
(Latest) J:211312 Woo SH, et al., Piezo2 is required for Merkel-cell mechanotransduction. Nature. 2014 May 29;509(7502):622-6
All references(301)
Other
accession IDs
MGD-MRK-26094

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory