Rr387 MGI Mouse Other Genome Feature Detail - MGI:7440031

Rr387 Other Genome Feature Detail

Sequence Map

Genome coordinates not available from the current reference assembly.
J:332270 deletion coordinates: chr6:64,733,006-64,735,029 (mm10) chr6:64709990-64712013 (GRCm39)

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
8 phenotypes from multigenic genotypes
2 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

Homozygous deletion of this Atoh1 enhancer doesn't lead to a hearing phenotype but does affect cerebellar development and impairs balance.

Summaries

All 4

Phenotypes 2
Earliest

J:60854 Helms AW, et al., Autoregulation and multiple enhancers control Math1 expression in the developing nervous system. Development. 2000 Mar;127(6):1185-96
Latest

J:333396 Luo Z, et al., Three distinct Atoh1 enhancers cooperate for sound receptor hair cell development. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2119850119

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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