Rr388 Other Genome Feature Detail

Summary

• Symbol
  Rr388
• Name
  regulatory region 388
• Synonyms
  E3

• Feature Type
  enhancer
• IDs
  MGI:7440032

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• J:332270 deletion coordinates: chr6:64,797,552-64,800,070 (mm10) chr6:64774536-64777054 (GRCm39)

• Genetic Map
  Chromosome 6, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 1 allele in 1 genetic background
  10 phenotypes from multigenic genotypes
  2 phenotype references
  

• All Mutations and Alleles
  2
• Endonuclease-mediated
  2
• Find Mice (IMSR)
  0 strains or lines available

Homozygous deletion of this Atoh1 enhancer leads to reduced cochlear hair cell numbers and reduced hearing.

References

• Summaries
  All 2

  Phenotypes 2
• Earliest
  J:332270 Shu M, et al., Single-cell chromatin accessibility identifies enhancer networks driving gene expression during spinal cord development in mouse. Dev Cell. 2022 Dec 19;57(24):2761-2775.e6
• Latest
  J:333396 Luo Z, et al., Three distinct Atoh1 enhancers cooperate for sound receptor hair cell development. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2119850119