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Alx1 Gene Detail
Summary
  • Symbol
    Alx1
  • Name
    ALX homeobox 1
  • Synonyms
    Cart1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104621
    NCBI Gene: 216285
  • Gene Overview
    MyGene.info: ALX1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:103007847-103029457 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 53.56 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104621
protein coding gene Chr10:102998707-103030215 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017697
protein coding gene Chr10:105037023-105063261 (-)
A/J MGP_AJ_G0017676
protein coding gene Chr10:101185573-101206955 (-)
AKR/J MGP_AKRJ_G0017638
protein coding gene Chr10:104151588-104172784 (-)
BALB/cJ MGP_BALBcJ_G0017640
protein coding gene Chr10:101541340-101562914 (-)
C3H/HeJ MGP_C3HHeJ_G0017465
protein coding gene Chr10:104159064-104183539 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018097
protein coding gene Chr10:108716415-108737648 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015776
protein coding gene Chr10:96431352-96452630 (-)
CAST/EiJ MGP_CASTEiJ_G0017026
protein coding gene Chr10:104240833-104265644 (-)
CBA/J MGP_CBAJ_G0017434
protein coding gene Chr10:112850764-112878086 (-)
DBA/2J MGP_DBA2J_G0017539
protein coding gene Chr10:100282522-100303990 (-)
FVB/NJ MGP_FVBNJ_G0017533
protein coding gene Chr10:99359258-99380912 (-)
LP/J MGP_LPJ_G0017613
protein coding gene Chr10:105645107-105667081 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017563
protein coding gene Chr10:114698638-114723095 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018135
protein coding gene Chr10:104072642-104096944 (-)
PWK/PhJ MGP_PWKPhJ_G0016808
protein coding gene Chr10:100395565-100417138 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016598
protein coding gene Chr10:102898824-102922864 (-)
WSB/EiJ MGP_WSBEiJ_G0017086
protein coding gene Chr10:104135879-104157368 (-)



Homology
more
  • Human Ortholog
    ALX1, ALX homeobox 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ALX1, ALX homeobox 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CART1, FND3, HEL23
  • Links
    NCBI Gene ID: 8092
    neXtProt AC: NX_Q15699
    UniProt: Q15699

  • Chr Location
    12q21.31; chr12:85280258-85301784 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5075
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ALX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 1 allele in 3 genetic backgrounds
    28 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit perinatal lethality with acrania and meroanencephaly, but the neural tube closure defect can be ameliorated with prenatal folic acid treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 216285 NCBI Gene Model | MGI Sequence Detail 21611 C57BL/6J ±  kb
    transcript NM_172553 RefSeq | MGI Sequence Detail 2493 C57BL/6  
    polypeptide Q8C8B0 UniProt | EBI | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 26
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-26058, MGI:2143564
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 33
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:257917 Magella B, et al., Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf. Dev Biol. 2018 Feb 1;434(1):36-47

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory