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Alx1
Gene Detail
 Symbol
Name
ID
Alx1
ALX homeobox 1
MGI:104621
Synonyms Cart1
Feature Type protein coding gene
Genetic Map
Chromosome 10
53.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:103007846-103029054 bp, - strand
From VEGA annotation of GRCm38

  21209 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Alx1

Human
homologs
Human Homolog ALX1, ALX homeobox 1
NCBI Gene ID 8092
neXtProt AC  NX_Q15699
Human Synonyms  CART1, FND3, HEL23
Human Chr (Location)  12q21.31; chr12:85279930-85301784 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ALX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygous mutant mice exhibit perinatal lethality with acrania and meroanencephaly, but the neural tube closure defect can be ameliorated with prenatal folic acid treatment.
 
Interactions
Alx1 interacts with 262 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process anterior/posterior pattern specification, embryonic limb morphogenesis, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (155)    Tissues (93)    Images (27)
Theiler Stages: 13, 15, 17, 18, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 155
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(24) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036202 (Evidence)
Ensembl Gene ModelENSMUSG00000036602 (Evidence)
Entrez Gene216285 (Evidence)
UniGene19287
DFCITC1582272
DoTSDT.101368553, DT.55280094, DT.91317458
NIA Mouse Gene IndexU032185
Consensus CDS ProjectCCDS24155.1
International Mouse Knockout Project StatusAlx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036202 VEGA Gene Model | MGI Sequence Detail 21209 C57BL/6J ±  kb
transcript OTTMUST00000093010 VEGA | MGI Sequence Detail 2689 Not Applicable 
polypeptide OTTMUSP00000051519 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000003978 ALX homeobox protein 1
References (Earliest) J:22211 Zhao GQ, et al., The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development. Mech Dev. 1994 Dec;48(3):245-54
(Latest) J:197015 Thompson PJ, et al., CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis. J Mol Biol. 2012 Feb 3;415(5):793-806
All references(61)
Other
accession IDs
MGD-MRK-26058, MGI:2143564

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory