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Alx1 Gene Detail
Summary
  • Symbol
    Alx1
  • Name
    ALX homeobox 1
  • Synonyms
    Cart1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104621
    NCBI Gene: 216285
Location & Maps
more
  • Sequence Map
    Chr10:103007846-103029054 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21209 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ALX1, ALX homeobox 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ALX1, ALX homeobox 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CART1, FND3, HEL23
  • Links
    NCBI Gene ID: 8092
    neXtProt AC: NX_Q15699

  • Chr Location
    12q21.31; chr12:85279795-85301784 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5075
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ALX1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ALX1 associations

Human Disease Mouse Models
       Frontonasal Dysplasia 3; FND3   OMIM: 613456
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 1 allele in 3 genetic backgrounds
    23 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Alx1
Homozygous mutant mice exhibit perinatal lethality with acrania and meroanencephaly, but the neural tube closure defect can be ameliorated with prenatal folic acid treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036202 VEGA Gene Model | MGI Sequence Detail 21209 C57BL/6J ±  kb
transcript OTTMUST00000093010 VEGA | MGI Sequence Detail 2689 Not Applicable  
polypeptide OTTMUSP00000051519 VEGA | MGI Sequence Detail 326 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    123 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 26
    Genomic 1
    cDNA 24
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-26058, MGI:2143564
References
more
  • Summaries
    All 57
    Developmental Gene Expression 26
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:22211 Zhao GQ, et al., The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development. Mech Dev. 1994 Dec;48(3):245-54
  • Latest
    J:214666 Brunskill EW, et al., A gene expression atlas of early craniofacial development. Dev Biol. 2014 Jul 15;391(2):133-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory