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Alx1
Gene Detail
Symbol

Name
ID
Alx1
ALX homeobox 1
MGI:104621
Synonyms
Cart1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
53.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:103007846-103029054 bp, - strand
From VEGA annotation of GRCm38

  21209 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ALX1
Gene Tree: Alx1

Human
homologs
ALX1, ALX homeobox 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8092
neXtProt AC: NX_Q15699

Human Synonyms: CART1, FND3, HEL23

Human Chr (Location): 12q21.31; chr12:85279795-85301784 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ALX1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygous mutant mice exhibit perinatal lethality with acrania and meroanencephaly, but the neural tube closure defect can be ameliorated with prenatal folic acid treatment.
 
Interactions
Alx1 interacts with 262 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process anterior/posterior pattern specification, embryonic limb morphogenesis, ...
Component Golgi apparatus, nucleoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (156)    Tissues (93)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 156
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ALX1 ; Xenbase alx1 ; ZFIN alx1    NEW 
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(24) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000036202 (Evidence)
Ensembl Gene Model ENSMUSG00000036602 (Evidence)
Entrez Gene 216285 (Evidence)
UniGene 19287
DFCI TC1582272
DoTS DT.101368553, DT.55280094, DT.91317458
NIA Mouse Gene Index U032185
Consensus CDS Project CCDS24155.1
International Mouse Phenotyping Consortium Status Alx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036202 VEGA Gene Model | MGI Sequence Detail 21209 C57BL/6J ±  kb
transcript OTTMUST00000093010 VEGA | MGI Sequence Detail 2689 Not Applicable 
polypeptide OTTMUSP00000051519 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000003978 ALX homeobox protein 1
References
(Earliest) J:22211 Zhao GQ, et al., The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development. Mech Dev. 1994 Dec;48(3):245-54
(Latest) J:214666 Brunskill EW, et al., A gene expression atlas of early craniofacial development. Dev Biol. 2014 Jul 15;391(2):133-46
All references(60)
Other
accession IDs
MGD-MRK-26058, MGI:2143564

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory