Alx1
Gene Detail

Symbol Name ID

Alx1 ALX homeobox 1 MGI:104621

Synonyms

Cart1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

53.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:103007847-103029051 bp, - strand From VEGA annotation of GRCm38   21205 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Alx1

Human homologs

Human Homolog		ALX1, ALX homeobox 1
NCBI Gene ID		8092
neXtProt AC		NX_Q15699
Human Synonyms		CART1, FND3
Human Chr (Location)		12q21.31; chr12:85674036-85695562 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ALX1

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous mutant mice exhibit perinatal lethality with acrania and meroanencephaly, but the neural tube closure defect can be ameliorated with prenatal folic acid treatment.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	anterior/posterior pattern specification, embryonic limb morphogenesis, ...
Component	nucleus, transcription factor complex
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (153)    Tissues (91)    Images (25)
Theiler Stages: 13, 15, 17, 18, 19, 21, 23, 28

Assay Type	Results
RNA in situ	153

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(1) cDNA(24)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000036202 (Evidence)
Ensembl Gene Model	ENSMUSG00000036602 (Evidence)
Entrez Gene	216285 (Evidence)
UniGene	19287
DFCI	TC1582272
DoTS	DT.101368553, DT.55280094, DT.91317458
NIA Mouse Gene Index	U032185
Consensus CDS Project	CCDS24155.1
International Mouse Knockout Project Status	Alx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036202	VEGA Gene Model | MGI Sequence Detail	21205	C57BL/6J
transcript	OTTMUST00000093010	VEGA | MGI Sequence Detail	2685	Not Applicable
polypeptide	OTTMUSP00000051519	VEGA | MGI Sequence Detail	326	Not Applicable

All sequences(30) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(106 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR003654	OAR domain
Protein Ontology	PR:000003978	ALX homeobox protein 1

References

(Earliest) J:22211 Zhao GQ, et al., The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development. Mech Dev. 1994 Dec;48(3):245-54
(Latest) J:185597 Ohmura T, et al., Neural tube defects by NUAK1 and NUAK2 double mutation. Dev Dyn. 2012 Aug;241(8):1350-64
All references(60)

Other accession IDs

MGD-MRK-26058, MGI:2143564