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Cnr1
Gene Detail
 Symbol
Name
ID
Cnr1
cannabinoid receptor 1 (brain)
MGI:104615
Synonyms CB1, CB1R
Feature Type protein coding gene
Genetic Map
Chromosome 4
16.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:33924593-33948831 bp, + strand
From VEGA annotation of GRCm38

  24239 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7273  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cannabinoid receptor 1
Gene Tree: Cnr1

Human
homologs
Human Homolog CNR1, cannabinoid receptor 1 (brain)
NCBI Gene ID 1268
neXtProt AC  NX_P21554
Human Synonyms  CANN6, CB1, CB1A, CB1K5, CB1R, CB-R, CNR
Human Chr (Location)  6q14-q15; chr6:88139864-88166688 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit abnormal behaviors, altered long term depression and susceptibility to induced seizure.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Cnr1 interacts with 396 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process adenylate cyclase-modulating G-protein coupled receptor signaling pathway, aging, ...
Component axon, growth cone, ...
Function cannabinoid receptor activity, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (164)    Tissues (148)    Images (22)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 118
RT-PCR 46
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(6) cDNA(18) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000008304 (Evidence)
Ensembl Gene ModelENSMUSG00000044288 (Evidence)
Entrez Gene12801 (Evidence)
DFCITC1583570, TC1716875
DoTSDT.101373656, DT.87049535, DT.91326421, DT.91434965
NIA Mouse Gene IndexU004178
Consensus CDS ProjectCCDS18025.1
International Mouse Knockout Project StatusCnr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008304 VEGA Gene Model | MGI Sequence Detail 24239 C57BL/6J ±  kb
transcript OTTMUST00000018900 VEGA | MGI Sequence Detail 5807 Not Applicable 
polypeptide OTTMUSP00000008684 VEGA | MGI Sequence Detail 473 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(12) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002230 Cannabinoid receptor
InterPro IPR000810 Cannabinoid receptor type 1
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001125 cannabinoid receptor 1
References (Earliest) J:29411 Paria BC, et al., The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9460-4
(Latest) J:211919 Soria-Gomez E, et al., The endocannabinoid system controls food intake via olfactory processes. Nat Neurosci. 2014 Mar;17(3):407-15
All references(304)
Other
accession IDs
MGD-MRK-26052

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory