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Cnr1 Gene Detail
Summary
  • Symbol
    Cnr1
  • Name
    cannabinoid receptor 1 (brain)
  • Synonyms
    CB1, CB1R
  • Feature Type
    protein coding gene
  • IDs
    MGI:104615
    NCBI Gene: 12801
  • Gene Overview
    MyGene.info: CNR1
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:33924593-33948831 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 16.28 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104615
protein coding gene Chr4:33923844-33948831 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028124
protein coding gene Chr4:31479235-31503473 (+)
A/J MGP_AJ_G0028082
protein coding gene Chr4:30360546-30384735 (+)
AKR/J MGP_AKRJ_G0028045
protein coding gene Chr4:31161707-31185896 (+)
BALB/cJ MGP_BALBcJ_G0028093
protein coding gene Chr4:30618634-30643242 (+)
C3H/HeJ MGP_C3HHeJ_G0027822
protein coding gene Chr4:31464396-31488840 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028535
protein coding gene Chr4:32702638-32726825 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025876
protein coding gene Chr4:28503512-28527716 (+)
CAST/EiJ MGP_CASTEiJ_G0027277
protein coding gene Chr4:31235188-31260871 (+)
CBA/J MGP_CBAJ_G0027794
protein coding gene Chr4:33776375-33800583 (+)
DBA/2J MGP_DBA2J_G0027938
protein coding gene Chr4:30347888-30372296 (+)
FVB/NJ MGP_FVBNJ_G0027904
protein coding gene Chr4:29785658-29809864 (+)
LP/J MGP_LPJ_G0028046
protein coding gene Chr4:31575686-31599766 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027937
protein coding gene Chr4:36367193-36391722 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028594
protein coding gene Chr4:31170723-31194950 (+)
PWK/PhJ MGP_PWKPhJ_G0026996
protein coding gene Chr4:30366034-30390763 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026825
protein coding gene Chr4:31050264-31074457 (+)
WSB/EiJ MGP_WSBEiJ_G0027353
protein coding gene Chr4:31175735-31200998 (+)



Homology
more
  • Human Ortholog
    CNR1, cannabinoid receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CNR1, cannabinoid receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CANN6, CB1, CB1A, CB1K5, CB1R, CB-R, CNR
  • Links
    NCBI Gene ID: 1268
    neXtProt AC: NX_P21554
    UniProt: P21554

  • Chr Location
    6q15; chr6:88139864-88167429 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    80 phenotypes from 12 alleles in 19 genetic backgrounds
    8 phenotypes from multigenic genotypes
    319 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal behaviors, altered long term depression and susceptibility to induced seizure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044288 Ensembl Gene Model | MGI Sequence Detail 24239 C57BL/6J ±  kb
    transcript ENSMUST00000057188 Ensembl | MGI Sequence Detail 5807 Not Applicable  
    polypeptide ENSMUSP00000055797 Ensembl | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 6
      cDNA 20
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-26052
    References
    more
    • Summaries
      All 435
      Developmental Gene Expression 30
      Diseases 1
      Gene Ontology 10
      Phenotypes 319
    • Earliest
      J:29411 Paria BC, et al., The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9460-4
    • Latest
      J:266912 Zimmermann T, et al., Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus. Cereb Cortex. 2018 Dec 1;28(12):4454-4471

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory